Research ArticleAccepted Article
Open Access
Pooled Safety Results Through One Year of Two Phase-3 Trials of Guselkumab in Patients with Psoriatic Arthritis
Proton Rahman, Christopher T. Ritchlin, Philip S. Helliwell, Wolf-Henning Boehncke, Philip J. Mease, Alice B. Gottlieb, Shelly Kafka, Alexa P. Kollmeier, Elizabeth C. Hsia, Xie L. Xu, May Shawi, Shihong Sheng, Prasheen Agarwal, Bei Zhou, Paraneedharan Ramachandran, Yanli Zhuang and Iain B. McInnes
The Journal of Rheumatology May 2021, jrheum.201532; DOI: https://doi.org/10.3899/jrheum.201532
Proton Rahman
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Christopher T. Ritchlin
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Philip S. Helliwell
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Wolf-Henning Boehncke
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Philip J. Mease
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Alice B. Gottlieb
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Shelly Kafka
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Alexa P. Kollmeier
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Elizabeth C. Hsia
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Xie L. Xu
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
May Shawi
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Shihong Sheng
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Prasheen Agarwal
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Bei Zhou
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Paraneedharan Ramachandran
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Yanli Zhuang
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
Iain B. McInnes
Memorial University of Newfoundland, St. Johns, Newfoundland, Canada; University of Rochester, Rochester, NY, USA; University of Leeds, Leeds, United Kingdom; Geneva University Hospitals, Geneva, Switzerland; Swedish Medical Center/Providence St Joseph Health and University of Washington School of Medicine, Seattle, WA, USA; Icahn Medical School/Mount Sinai, New York, NY, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Janssen Research & Development, LLC, San Diego, CA, USA; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Janssen Global Services, LLC, Horsham, PA, USA; University of Glasgow, Glasgow, United Kingdom. CT Ritchlin received research support (AbbVie, Amgen, UCB Pharma); consultant fees (AbbVie, Amgen, Gilead, Janssen, Lilly, Novartis, Pfizer, UCB Pharma) P Rahman received research support (Janssen, Novartis); consultant fees (Abbott, AbbVie, Amgen, BMS, Celgene, Eli Lilly, Janssen, Novartis, Pfizer, Roche, UCB); speaker bureau support (AbbVie, Eli Lilly, Janssen, Novartis, Pfizer, UCB) PS Helliwell received consulting fees (Eli Lilly) and fees for educational services (Amgen, Janssen, Novartis, Pfizer). W-H Boehncke received research support (Pfizer); consulting fees and speaker bureau support (AbbVie, Almirall, Celgene, Janssen, Leo, Lilly, Novartis, UCB) IB McInnes received research support (Astra Zeneca, Bristol-Myers Squibb, Celgene, Janssen, Lilly, Novartis, UCB); consultant fees (AbbVie, Bristol-Myers Squibb, Boehringer-Ingelheim, Celgene, Eli Lilly, Gilead, Janssen, Novartis, UCB). AB Gottlieb received research support (Janssen-Ortho, Boehringer Ingelheim, Incyte, Janssen, Novartis, Pharmaceutical Industries, UCB, Xbiotech); honoraria (Amgen, Bristol Myers Squibb, Celgene, Janssen Biotech, Janssen-Ortho, LEO Pharma, Novartis, UCB); consultant fees (AnaptysBio, Avotres, Boehringer Ingelheim, Incyte, Lilly ICOS, Novartis, Pfizer, Pharmaceutical Industries); and stock options (XBiotech). PJ Mease received research support, consulting fees, and speaker bureau support (AbbVie, Amgen, BMS, Celgene, Crescendo Bioscience, Genentech, Janssen, Lilly, Merck, Novartis, Pfizer, UCB) S Kafka, was an employee of Janssen Scientific Affairs, LLC, at the time this work was performed; A Kollmeier, E Hsia, XL Xu, S Sheng, P Agarwal, B Zhou, P Ramachandran, and Y Zhuang are employees of Janssen Research & Development, LLC; and M Shawi is an employee of Janssen Global Services, LLC, and own stock or stock options in Johnson & Johnson. Address correspondence to: Dr. Proton Rahman, 154 LeMarchant Rd, St. Clare’s Mercy Hospital, St. John’s Newfoundland, Canada A1C 5B8
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Accepted manuscript
Pooled Safety Results Through One Year of Two Phase-3 Trials of Guselkumab in Patients with Psoriatic Arthritis
Proton Rahman, Christopher T. Ritchlin, Philip S. Helliwell, Wolf-Henning Boehncke, Philip J. Mease, Alice B. Gottlieb, Shelly Kafka, Alexa P. Kollmeier, Elizabeth C. Hsia, Xie L. Xu, May Shawi, Shihong Sheng, Prasheen Agarwal, Bei Zhou, Paraneedharan Ramachandran, Yanli Zhuang, Iain B. McInnes
The Journal of Rheumatology May 2021, jrheum.201532; DOI: 10.3899/jrheum.201532
Accepted manuscript
Pooled Safety Results Through One Year of Two Phase-3 Trials of Guselkumab in Patients with Psoriatic Arthritis
Proton Rahman, Christopher T. Ritchlin, Philip S. Helliwell, Wolf-Henning Boehncke, Philip J. Mease, Alice B. Gottlieb, Shelly Kafka, Alexa P. Kollmeier, Elizabeth C. Hsia, Xie L. Xu, May Shawi, Shihong Sheng, Prasheen Agarwal, Bei Zhou, Paraneedharan Ramachandran, Yanli Zhuang, Iain B. McInnes
The Journal of Rheumatology May 2021, jrheum.201532; DOI: 10.3899/jrheum.201532