Research ArticleArticle
Open Access
Increased Risk of Valvular Heart Disease in Systemic Sclerosis: An Underrecognized Cardiac Complication
Reto D. Kurmann, Edward A. El-Am, Yasser A. Radwan, Avneek S. Sandhu, Cynthia S. Crowson, Eric L. Matteson, Kenneth J. Warrington, Rekha Mankad and Ashima Makol
The Journal of Rheumatology January 2021, jrheum.201005; DOI: https://doi.org/10.3899/jrheum.201005
Reto D. Kurmann
This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health (NIH) under Award Number R01AG034676, and Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), one of the institutes of the NIH. The study was also supported by the John M. Nasseff, Sr. Clinician Career Development Award in Rheumatology to AM and Mayo Clinic CTSA through grant number UL1 TR002377 from the NCATS. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. RDK received funding from Research Funds of the Department of Rheumatology and Clinical Immunology, University of Bern, Switzerland. R.D. Kurmann, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA, and Department of Cardiology, Heart Center Lucerne Hospital, Lucerne, Switzerland; E.A. El-Am, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, and Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; Y.A. Radwan, MD, K.J. Warrington, MD, A. Makol, MD, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA; A.S. Sandhu, MD, Department of Medicine, Kettering Health Medical Center, Dayton, Ohio, USA; C.S. Crowson, PhD, E.L. Matteson, MD, MPH, Division of Rheumatology, and Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA; R. Mankad, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA. The authors declare no conflicts of interest. Address correspondence to Dr. A. Makol, Associate Professor of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN 55905, USA. Email: makol.ashima@mayo.edu. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 17, 2020.
Edward A. El-Am
This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health (NIH) under Award Number R01AG034676, and Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), one of the institutes of the NIH. The study was also supported by the John M. Nasseff, Sr. Clinician Career Development Award in Rheumatology to AM and Mayo Clinic CTSA through grant number UL1 TR002377 from the NCATS. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. RDK received funding from Research Funds of the Department of Rheumatology and Clinical Immunology, University of Bern, Switzerland. R.D. Kurmann, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA, and Department of Cardiology, Heart Center Lucerne Hospital, Lucerne, Switzerland; E.A. El-Am, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, and Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; Y.A. Radwan, MD, K.J. Warrington, MD, A. Makol, MD, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA; A.S. Sandhu, MD, Department of Medicine, Kettering Health Medical Center, Dayton, Ohio, USA; C.S. Crowson, PhD, E.L. Matteson, MD, MPH, Division of Rheumatology, and Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA; R. Mankad, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA. The authors declare no conflicts of interest. Address correspondence to Dr. A. Makol, Associate Professor of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN 55905, USA. Email: makol.ashima@mayo.edu. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 17, 2020.
Yasser A. Radwan
This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health (NIH) under Award Number R01AG034676, and Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), one of the institutes of the NIH. The study was also supported by the John M. Nasseff, Sr. Clinician Career Development Award in Rheumatology to AM and Mayo Clinic CTSA through grant number UL1 TR002377 from the NCATS. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. RDK received funding from Research Funds of the Department of Rheumatology and Clinical Immunology, University of Bern, Switzerland. R.D. Kurmann, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA, and Department of Cardiology, Heart Center Lucerne Hospital, Lucerne, Switzerland; E.A. El-Am, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, and Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; Y.A. Radwan, MD, K.J. Warrington, MD, A. Makol, MD, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA; A.S. Sandhu, MD, Department of Medicine, Kettering Health Medical Center, Dayton, Ohio, USA; C.S. Crowson, PhD, E.L. Matteson, MD, MPH, Division of Rheumatology, and Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA; R. Mankad, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA. The authors declare no conflicts of interest. Address correspondence to Dr. A. Makol, Associate Professor of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN 55905, USA. Email: makol.ashima@mayo.edu. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 17, 2020.
Avneek S. Sandhu
This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health (NIH) under Award Number R01AG034676, and Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), one of the institutes of the NIH. The study was also supported by the John M. Nasseff, Sr. Clinician Career Development Award in Rheumatology to AM and Mayo Clinic CTSA through grant number UL1 TR002377 from the NCATS. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. RDK received funding from Research Funds of the Department of Rheumatology and Clinical Immunology, University of Bern, Switzerland. R.D. Kurmann, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA, and Department of Cardiology, Heart Center Lucerne Hospital, Lucerne, Switzerland; E.A. El-Am, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, and Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; Y.A. Radwan, MD, K.J. Warrington, MD, A. Makol, MD, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA; A.S. Sandhu, MD, Department of Medicine, Kettering Health Medical Center, Dayton, Ohio, USA; C.S. Crowson, PhD, E.L. Matteson, MD, MPH, Division of Rheumatology, and Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA; R. Mankad, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA. The authors declare no conflicts of interest. Address correspondence to Dr. A. Makol, Associate Professor of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN 55905, USA. Email: makol.ashima@mayo.edu. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 17, 2020.
Cynthia S. Crowson
This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health (NIH) under Award Number R01AG034676, and Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), one of the institutes of the NIH. The study was also supported by the John M. Nasseff, Sr. Clinician Career Development Award in Rheumatology to AM and Mayo Clinic CTSA through grant number UL1 TR002377 from the NCATS. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. RDK received funding from Research Funds of the Department of Rheumatology and Clinical Immunology, University of Bern, Switzerland. R.D. Kurmann, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA, and Department of Cardiology, Heart Center Lucerne Hospital, Lucerne, Switzerland; E.A. El-Am, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, and Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; Y.A. Radwan, MD, K.J. Warrington, MD, A. Makol, MD, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA; A.S. Sandhu, MD, Department of Medicine, Kettering Health Medical Center, Dayton, Ohio, USA; C.S. Crowson, PhD, E.L. Matteson, MD, MPH, Division of Rheumatology, and Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA; R. Mankad, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA. The authors declare no conflicts of interest. Address correspondence to Dr. A. Makol, Associate Professor of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN 55905, USA. Email: makol.ashima@mayo.edu. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 17, 2020.
Eric L. Matteson
This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health (NIH) under Award Number R01AG034676, and Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), one of the institutes of the NIH. The study was also supported by the John M. Nasseff, Sr. Clinician Career Development Award in Rheumatology to AM and Mayo Clinic CTSA through grant number UL1 TR002377 from the NCATS. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. RDK received funding from Research Funds of the Department of Rheumatology and Clinical Immunology, University of Bern, Switzerland. R.D. Kurmann, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA, and Department of Cardiology, Heart Center Lucerne Hospital, Lucerne, Switzerland; E.A. El-Am, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, and Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; Y.A. Radwan, MD, K.J. Warrington, MD, A. Makol, MD, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA; A.S. Sandhu, MD, Department of Medicine, Kettering Health Medical Center, Dayton, Ohio, USA; C.S. Crowson, PhD, E.L. Matteson, MD, MPH, Division of Rheumatology, and Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA; R. Mankad, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA. The authors declare no conflicts of interest. Address correspondence to Dr. A. Makol, Associate Professor of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN 55905, USA. Email: makol.ashima@mayo.edu. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 17, 2020.
Kenneth J. Warrington
This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health (NIH) under Award Number R01AG034676, and Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), one of the institutes of the NIH. The study was also supported by the John M. Nasseff, Sr. Clinician Career Development Award in Rheumatology to AM and Mayo Clinic CTSA through grant number UL1 TR002377 from the NCATS. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. RDK received funding from Research Funds of the Department of Rheumatology and Clinical Immunology, University of Bern, Switzerland. R.D. Kurmann, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA, and Department of Cardiology, Heart Center Lucerne Hospital, Lucerne, Switzerland; E.A. El-Am, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, and Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; Y.A. Radwan, MD, K.J. Warrington, MD, A. Makol, MD, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA; A.S. Sandhu, MD, Department of Medicine, Kettering Health Medical Center, Dayton, Ohio, USA; C.S. Crowson, PhD, E.L. Matteson, MD, MPH, Division of Rheumatology, and Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA; R. Mankad, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA. The authors declare no conflicts of interest. Address correspondence to Dr. A. Makol, Associate Professor of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN 55905, USA. Email: makol.ashima@mayo.edu. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 17, 2020.
Rekha Mankad
This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health (NIH) under Award Number R01AG034676, and Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), one of the institutes of the NIH. The study was also supported by the John M. Nasseff, Sr. Clinician Career Development Award in Rheumatology to AM and Mayo Clinic CTSA through grant number UL1 TR002377 from the NCATS. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. RDK received funding from Research Funds of the Department of Rheumatology and Clinical Immunology, University of Bern, Switzerland. R.D. Kurmann, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA, and Department of Cardiology, Heart Center Lucerne Hospital, Lucerne, Switzerland; E.A. El-Am, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, and Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; Y.A. Radwan, MD, K.J. Warrington, MD, A. Makol, MD, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA; A.S. Sandhu, MD, Department of Medicine, Kettering Health Medical Center, Dayton, Ohio, USA; C.S. Crowson, PhD, E.L. Matteson, MD, MPH, Division of Rheumatology, and Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA; R. Mankad, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA. The authors declare no conflicts of interest. Address correspondence to Dr. A. Makol, Associate Professor of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN 55905, USA. Email: makol.ashima@mayo.edu. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 17, 2020.
Ashima Makol
This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health (NIH) under Award Number R01AG034676, and Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), one of the institutes of the NIH. The study was also supported by the John M. Nasseff, Sr. Clinician Career Development Award in Rheumatology to AM and Mayo Clinic CTSA through grant number UL1 TR002377 from the NCATS. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. RDK received funding from Research Funds of the Department of Rheumatology and Clinical Immunology, University of Bern, Switzerland. R.D. Kurmann, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA, and Department of Cardiology, Heart Center Lucerne Hospital, Lucerne, Switzerland; E.A. El-Am, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, and Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; Y.A. Radwan, MD, K.J. Warrington, MD, A. Makol, MD, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA; A.S. Sandhu, MD, Department of Medicine, Kettering Health Medical Center, Dayton, Ohio, USA; C.S. Crowson, PhD, E.L. Matteson, MD, MPH, Division of Rheumatology, and Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA; R. Mankad, MD, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA. The authors declare no conflicts of interest. Address correspondence to Dr. A. Makol, Associate Professor of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN 55905, USA. Email: makol.ashima@mayo.edu. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 17, 2020.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Increased Risk of Valvular Heart Disease in Systemic Sclerosis: An Underrecognized Cardiac Complication
Reto D. Kurmann, Edward A. El-Am, Yasser A. Radwan, Avneek S. Sandhu, Cynthia S. Crowson, Eric L. Matteson, Kenneth J. Warrington, Rekha Mankad, Ashima Makol
The Journal of Rheumatology Jan 2021, jrheum.201005; DOI: 10.3899/jrheum.201005
Increased Risk of Valvular Heart Disease in Systemic Sclerosis: An Underrecognized Cardiac Complication
Reto D. Kurmann, Edward A. El-Am, Yasser A. Radwan, Avneek S. Sandhu, Cynthia S. Crowson, Eric L. Matteson, Kenneth J. Warrington, Rekha Mankad, Ashima Makol
The Journal of Rheumatology Jan 2021, jrheum.201005; DOI: 10.3899/jrheum.201005