Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • GDPR Policy
    • Accessibility
  • Contact Us
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on RSS
Research ArticleAccepted Article

Reviewing disease activity indices in spondyloarthritis from the gender perspective: A systematic review and meta-analysis

Mar Blasco-Blasco, Isabel Castrejón, Vega Jovaní, Eliseo Pascual and María Teresa Ruiz-Cantero
The Journal of Rheumatology April 2021, jrheum.200967; DOI: https://doi.org/10.3899/jrheum.200967
Mar Blasco-Blasco
Public Health Research Group. University of Alicante, Alicante, Spain. Division of Rheumatology, Rush University Medical Center, Chicago, IL, the United States. Department of Rheumatology, Alicante University General Hospital, Alicante, Spain. Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain. 5CIBERESP (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública), Alicante, Spain. Funding MBB has received two scholarships from the Instituto Universitario de Investigación en Estudios de Género (Universidad de Alicante, Spain) and the Facultad de Ciencias de la Salud (Universidad de Alicante, Spain) to support this study as her doctoral training. No commercial support has been received to carry out this study. Correspondence to Mar Blasco-Blasco, Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia. Universidad de Alicante, Apartado Postal 99. Crta. San Vicente-Alicante s/n. 03080, Alicante (Spain) E-mail: marblasco204@gmail.com
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Isabel Castrejón
Public Health Research Group. University of Alicante, Alicante, Spain. Division of Rheumatology, Rush University Medical Center, Chicago, IL, the United States. Department of Rheumatology, Alicante University General Hospital, Alicante, Spain. Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain. 5CIBERESP (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública), Alicante, Spain. Funding MBB has received two scholarships from the Instituto Universitario de Investigación en Estudios de Género (Universidad de Alicante, Spain) and the Facultad de Ciencias de la Salud (Universidad de Alicante, Spain) to support this study as her doctoral training. No commercial support has been received to carry out this study. Correspondence to Mar Blasco-Blasco, Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia. Universidad de Alicante, Apartado Postal 99. Crta. San Vicente-Alicante s/n. 03080, Alicante (Spain) E-mail: marblasco204@gmail.com
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vega Jovaní
Public Health Research Group. University of Alicante, Alicante, Spain. Division of Rheumatology, Rush University Medical Center, Chicago, IL, the United States. Department of Rheumatology, Alicante University General Hospital, Alicante, Spain. Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain. 5CIBERESP (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública), Alicante, Spain. Funding MBB has received two scholarships from the Instituto Universitario de Investigación en Estudios de Género (Universidad de Alicante, Spain) and the Facultad de Ciencias de la Salud (Universidad de Alicante, Spain) to support this study as her doctoral training. No commercial support has been received to carry out this study. Correspondence to Mar Blasco-Blasco, Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia. Universidad de Alicante, Apartado Postal 99. Crta. San Vicente-Alicante s/n. 03080, Alicante (Spain) E-mail: marblasco204@gmail.com
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eliseo Pascual
Public Health Research Group. University of Alicante, Alicante, Spain. Division of Rheumatology, Rush University Medical Center, Chicago, IL, the United States. Department of Rheumatology, Alicante University General Hospital, Alicante, Spain. Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain. 5CIBERESP (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública), Alicante, Spain. Funding MBB has received two scholarships from the Instituto Universitario de Investigación en Estudios de Género (Universidad de Alicante, Spain) and the Facultad de Ciencias de la Salud (Universidad de Alicante, Spain) to support this study as her doctoral training. No commercial support has been received to carry out this study. Correspondence to Mar Blasco-Blasco, Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia. Universidad de Alicante, Apartado Postal 99. Crta. San Vicente-Alicante s/n. 03080, Alicante (Spain) E-mail: marblasco204@gmail.com
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
María Teresa Ruiz-Cantero
Public Health Research Group. University of Alicante, Alicante, Spain. Division of Rheumatology, Rush University Medical Center, Chicago, IL, the United States. Department of Rheumatology, Alicante University General Hospital, Alicante, Spain. Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain. 5CIBERESP (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública), Alicante, Spain. Funding MBB has received two scholarships from the Instituto Universitario de Investigación en Estudios de Género (Universidad de Alicante, Spain) and the Facultad de Ciencias de la Salud (Universidad de Alicante, Spain) to support this study as her doctoral training. No commercial support has been received to carry out this study. Correspondence to Mar Blasco-Blasco, Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia. Universidad de Alicante, Apartado Postal 99. Crta. San Vicente-Alicante s/n. 03080, Alicante (Spain) E-mail: marblasco204@gmail.com
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • References
  • Info & Metrics
  • PDF
  • eLetters
PreviousNext
Loading

Abstract

Objective To determine whether the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Ankylosing Spondylitis Disease Activity Score (ASDAS) exhibited differences between women and men.

Methods We systematically searched MEDLINE, Embase, Web of Science and other sources in English or Spanish from 01 January 1995 to 31 July 2020, to assess the differences according to sex in BASDAI and ASDAS. We performed a comparative analysis by sex using t-student test and mean difference by sex meta-analyses for BASDAI and ASDAS, using a random-effects model via the inverse-variance method.

Results Forty-one studies included BASDAI (6,785 women/12,929 men) and 16 of them included ASDAS (2,046 women/4,403 men). Disease activity detected through BASDAI was significantly higher in women than in men (mean: 4.9 vs. 4.2, p=0.02), whereas ASDAS did not detect differences between sexes (mean: 2.8 women vs. 2.8 men). In the meta-analyses, BASDAI detected significant differences between women and men [mean difference= 0.55 (95% confidence intervals (95%CI): 0.46, 0.65), p<0.00001], but ASDAS did not identify significant mean difference between sexes [0.04 (95%CI: -0.05, 0.12), p=0.38].

Conclusion The two most widely used indexes of disease activity in spondyloarthritis discriminate differently according to sex by their different evaluation of peripheral disease. Their different components and weights influence BASDAI and ASDAS values. BASDAI may be influenced by fatigue, but in predominantly peripheral manifestations like enthesitis, ASDAS may not be sensitive enough to detect activity. This may represent a gender bias unfavourable to women, because peripheral spondyloarthritis is more common in women than in men.

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

The Journal of Rheumatology
Vol. 48, Issue 4
1 Apr 2021
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Reviewing disease activity indices in spondyloarthritis from the gender perspective: A systematic review and meta-analysis
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Accepted manuscript
Reviewing disease activity indices in spondyloarthritis from the gender perspective: A systematic review and meta-analysis
Mar Blasco-Blasco, Isabel Castrejón, Vega Jovaní, Eliseo Pascual, María Teresa Ruiz-Cantero
The Journal of Rheumatology Apr 2021, jrheum.200967; DOI: 10.3899/jrheum.200967

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
Accepted manuscript
Reviewing disease activity indices in spondyloarthritis from the gender perspective: A systematic review and meta-analysis
Mar Blasco-Blasco, Isabel Castrejón, Vega Jovaní, Eliseo Pascual, María Teresa Ruiz-Cantero
The Journal of Rheumatology Apr 2021, jrheum.200967; DOI: 10.3899/jrheum.200967
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Save to my folders

Jump to section

  • Article
  • References
  • Info & Metrics
  • PDF
  • eLetters

Related Articles

Cited By...

More in this TOC Section

  • Test-retest reliability for HAQ-DI and SF-36 PF for the measurement of physical function in psoriatic arthritis
  • Psoriasis characteristics for the early detection of psoriatic arthritis
  • Effects of denosumab in Japanese rheumatoid arthritis patients treated with conventional anti-rheumatic drugs: 36-month extension of a phase 3 study
Show more Accepted Article

Similar Articles

Content

  • First Release
  • Current
  • Archives
  • Collections
  • Audiovisual Rheum
  • COVID-19 and Rheumatology

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2016 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire