Research ArticleArticle
The Association of Airway Comorbidities With the Clinical Phenotypes and Outcomes of Patients With Antineutrophil Cytoplasmic Autoantibody–associated Vasculitis
Nobuyuki Ono, Yasushi Inoue, Tomoya Miyamura, Naoyasu Ueda, Shuji Nagano, Hisako Inoue, Kensuke Oryoji, Shun-ichiro Ota, Takuya Sawabe, Seiji Yoshizawa, Yukiko Takeyama, Yuri Sadanaga, Ayako Takamori, Yasutaka Kimoto, Katsuhisa Miyake, Takahiko Horiuchi, Hitoshi Nakashima, Hiroaki Niiro and Yoshifumi Tada
The Journal of Rheumatology September 2019, jrheum.190373; DOI: https://doi.org/10.3899/jrheum.190373
Nobuyuki Ono
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Yasushi Inoue
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Tomoya Miyamura
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Naoyasu Ueda
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Shuji Nagano
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Hisako Inoue
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Kensuke Oryoji
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Shun-ichiro Ota
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Takuya Sawabe
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Seiji Yoshizawa
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Yukiko Takeyama
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Yuri Sadanaga
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Ayako Takamori
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Yasutaka Kimoto
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Katsuhisa Miyake
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Takahiko Horiuchi
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Hitoshi Nakashima
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Hiroaki Niiro
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Yoshifumi Tada
N. Ono, MD, PhD, Y. Sadanaga, MD, Y. Tada, MD, PhD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga; Y. Inoue, MD, PhD, Department of Rheumatology, Fukuoka Red Cross Hospital; T. Miyamura, MD, PhD, Department of Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; N. Ueda, MD, PhD, Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki; S. Nagano, MD, Department of Rheumatology, Iizuka Hospital; H. Inoue, MD, PhD, Department of Rheumatology, Saiseikai Fukuoka Hospital, Fukuoka; K. Oryoji, MD, Department of Rheumatology, Matsuyama Red Cross Hospital, Matsuyama; S. Ota, MD, Department of Rheumatology, Shimonoseki City Hospital, Shimonoseki; T. Sawabe, MD, PhD, Department of Rheumatology, Hiroshima Red Cross Hospital, Hiroshima; S. Yoshizawa, MD, PhD, Department of Rheumatology, Hamanomachi Hospital, Fukuoka; Y. Takeyama, MD, Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Department of Rheumatology, Saiseikai Karatsu Hospital, Karatsu; A. Takamori, MD, PhD, Clinical Research Center, Saga University Hospital, Saga; Y. Kimoto, MD, T. Horiuchi, MD, PhD, Department of Rheumatology, Kyushu University Beppu Hospital, Beppu; K. Miyake, MD, PhD, H. Nakashima, MD, PhD, Department of Rheumatology, Fukuoka University; H. Niiro, MD, PhD, Department of Rheumatology, Kyushu University, Fukuoka, Japan. The authors declare no conflicts of interest. Address correspondence to Dr. N. Ono, Department of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. Email: nono@cc.saga-u.ac.jp. Accepted for publication August 1, 2019.
Abstract
Objective We investigated the association of airway comorbidities with the clinical phenotypes and outcomes of myeloperoxidase (MPO)–antineutrophil cytoplasmic antibodies (ANCA)–positive ANCA‑associated vasculitis (AAV).
Methods An AAV patient multicenter cohort trial was established in 13 hospitals in western Japan between 2012 and 2018. We examined 143 of the new-onset MPO-ANCA–positive AAV patients. Their clinical characteristics and comorbidities at disease onset were compared based on clinical phenotypes. Multivariate analysis was performed to identify factors predictive of remission and death.
Results Twenty-seven cases with granulomatosis with polyangiitis (GPA), 10 with eosinophilic GPA (EGPA), 81 with microscopic polyangiitis (MPA), and 25 with unclassified AAV were identified. The average age of MPO-ANCA–positive patients was 71.4 years. Comorbidity (87.4%) and airway comorbidity (70.6%) were frequently observed in these patients. Examination of the clinical phenotypes revealed that the cases of GPA were frequently accompanied by infectious airway comorbidity (upper airway disease, bronchiectasis, pulmonary infections), and most of the cases of MPA and unclassified AAV were accompanied by fibrotic interstitial lung disease (fILD) or emphysema. Among MPO-ANCA–positive patients, infectious airway comorbidity was predictive of both remission (HR 1.58, P = 0.03) and mortality (HR 2.64, P = 0.04), and fILD was predictive of mortality (HR 7.55, P = 0.008). The combination of infectious airway comorbidities and fILD caused the worst survival outcomes in patients.
Conclusion MPO-ANCA–positive AAV was frequently accompanied by airway comorbidities. In addition to fILD, infectious airway comorbidities were closely associated with those clinical phenotypes and outcomes.
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In this issue
The Journal of Rheumatology
Vol. 48, Issue 1
1 Jan 2021
The Association of Airway Comorbidities With the Clinical Phenotypes and Outcomes of Patients With Antineutrophil Cytoplasmic Autoantibody–associated Vasculitis
Nobuyuki Ono, Yasushi Inoue, Tomoya Miyamura, Naoyasu Ueda, Shuji Nagano, Hisako Inoue, Kensuke Oryoji, Shun-ichiro Ota, Takuya Sawabe, Seiji Yoshizawa, Yukiko Takeyama, Yuri Sadanaga, Ayako Takamori, Yasutaka Kimoto, Katsuhisa Miyake, Takahiko Horiuchi, Hitoshi Nakashima, Hiroaki Niiro, Yoshifumi Tada
The Journal of Rheumatology Sep 2019, jrheum.190373; DOI: 10.3899/jrheum.190373
The Association of Airway Comorbidities With the Clinical Phenotypes and Outcomes of Patients With Antineutrophil Cytoplasmic Autoantibody–associated Vasculitis
Nobuyuki Ono, Yasushi Inoue, Tomoya Miyamura, Naoyasu Ueda, Shuji Nagano, Hisako Inoue, Kensuke Oryoji, Shun-ichiro Ota, Takuya Sawabe, Seiji Yoshizawa, Yukiko Takeyama, Yuri Sadanaga, Ayako Takamori, Yasutaka Kimoto, Katsuhisa Miyake, Takahiko Horiuchi, Hitoshi Nakashima, Hiroaki Niiro, Yoshifumi Tada
The Journal of Rheumatology Sep 2019, jrheum.190373; DOI: 10.3899/jrheum.190373
