Research ArticleAccepted Article
Relationship between Depression and Disease Activity in United States Veterans with Early Rheumatoid Arthritis Receiving Methotrexate
Alan M. Rathbun, Bryant R. England, Ted R. Mikuls, Alice S. Ryan, Jennifer L. Barton, Michelle D. Shardell and Marc C. Hochberg
The Journal of Rheumatology November 2020, jrheum.200743; DOI: https://doi.org/10.3899/jrheum.200743
Alan M. Rathbun
Department of Epidemiology and Public Health, Department of Medicine, University of Maryland Baltimore, School of Medicine, Baltimore, MD 21201; VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105; Department of Internal Medicine, University of Nebraska Medical Center, College of Medicine, Omaha, NE 68198; VA Maryland Health Care System, Baltimore, MD 21201; VA Portland Health Care System, Portland, OR 97239; Department of Medicine, Oregon Health & Science University, School of Medicine, Portland, OR 97239. Funding: This study was supported by the Rheumatology Research Foundation’s Scientist Development Award and grants from the National Institute on Aging (K01 AG064041, R01 AG048069, P30 AG028747), VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Conflicts of Interest: Dr. Alan M. Rathbun is supported by grants from the Rheumatology Research Foundation and National Institute on Aging (NIA; K01 AG064041). Dr. Bryant R. England and Ted R. Mikuls are supported by grants from the Rheumatology Research Foundation, VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Dr. Jennifer L. Barton is supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23 AR064372). Dr. Alice S. Ryan is supported by grants from the VA Rehabilitation Research and Development Service (N9273, I01 RX002790, I01 RX001461, I21 RX002870), NIA (P30 AG028747), and National Institute on Diabetes and Digestive and Kidney Disease (P30 DK072488). Dr. Michelle D. Shardell is supported by grants from NIA (R01 AG048069). Dr. Marc C. Hochberg is the President of Rheumcon Corporation and receives consulting fees from Bioiberica SA, Bristol-Myers Squibb, Eli Lilly, EMD Serono, Galapagos, IBSA Biotechniq SA, Novartis Pharma AG, Pfizer, Plexxikon, Samumed LLC, Theralogix LLC, and TissueGene Inc. Corresponding Author: Alan M. Rathbun, PhD, MPH, Howard Hall Suite 200, 660 W. Redwood Street, University of Maryland School of Medicine, Baltimore, MD 21201. Email: arathbun@som.umaryland.edu
Bryant R. England
Department of Epidemiology and Public Health, Department of Medicine, University of Maryland Baltimore, School of Medicine, Baltimore, MD 21201; VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105; Department of Internal Medicine, University of Nebraska Medical Center, College of Medicine, Omaha, NE 68198; VA Maryland Health Care System, Baltimore, MD 21201; VA Portland Health Care System, Portland, OR 97239; Department of Medicine, Oregon Health & Science University, School of Medicine, Portland, OR 97239. Funding: This study was supported by the Rheumatology Research Foundation’s Scientist Development Award and grants from the National Institute on Aging (K01 AG064041, R01 AG048069, P30 AG028747), VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Conflicts of Interest: Dr. Alan M. Rathbun is supported by grants from the Rheumatology Research Foundation and National Institute on Aging (NIA; K01 AG064041). Dr. Bryant R. England and Ted R. Mikuls are supported by grants from the Rheumatology Research Foundation, VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Dr. Jennifer L. Barton is supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23 AR064372). Dr. Alice S. Ryan is supported by grants from the VA Rehabilitation Research and Development Service (N9273, I01 RX002790, I01 RX001461, I21 RX002870), NIA (P30 AG028747), and National Institute on Diabetes and Digestive and Kidney Disease (P30 DK072488). Dr. Michelle D. Shardell is supported by grants from NIA (R01 AG048069). Dr. Marc C. Hochberg is the President of Rheumcon Corporation and receives consulting fees from Bioiberica SA, Bristol-Myers Squibb, Eli Lilly, EMD Serono, Galapagos, IBSA Biotechniq SA, Novartis Pharma AG, Pfizer, Plexxikon, Samumed LLC, Theralogix LLC, and TissueGene Inc. Corresponding Author: Alan M. Rathbun, PhD, MPH, Howard Hall Suite 200, 660 W. Redwood Street, University of Maryland School of Medicine, Baltimore, MD 21201. Email: arathbun@som.umaryland.edu
Ted R. Mikuls
Department of Epidemiology and Public Health, Department of Medicine, University of Maryland Baltimore, School of Medicine, Baltimore, MD 21201; VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105; Department of Internal Medicine, University of Nebraska Medical Center, College of Medicine, Omaha, NE 68198; VA Maryland Health Care System, Baltimore, MD 21201; VA Portland Health Care System, Portland, OR 97239; Department of Medicine, Oregon Health & Science University, School of Medicine, Portland, OR 97239. Funding: This study was supported by the Rheumatology Research Foundation’s Scientist Development Award and grants from the National Institute on Aging (K01 AG064041, R01 AG048069, P30 AG028747), VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Conflicts of Interest: Dr. Alan M. Rathbun is supported by grants from the Rheumatology Research Foundation and National Institute on Aging (NIA; K01 AG064041). Dr. Bryant R. England and Ted R. Mikuls are supported by grants from the Rheumatology Research Foundation, VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Dr. Jennifer L. Barton is supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23 AR064372). Dr. Alice S. Ryan is supported by grants from the VA Rehabilitation Research and Development Service (N9273, I01 RX002790, I01 RX001461, I21 RX002870), NIA (P30 AG028747), and National Institute on Diabetes and Digestive and Kidney Disease (P30 DK072488). Dr. Michelle D. Shardell is supported by grants from NIA (R01 AG048069). Dr. Marc C. Hochberg is the President of Rheumcon Corporation and receives consulting fees from Bioiberica SA, Bristol-Myers Squibb, Eli Lilly, EMD Serono, Galapagos, IBSA Biotechniq SA, Novartis Pharma AG, Pfizer, Plexxikon, Samumed LLC, Theralogix LLC, and TissueGene Inc. Corresponding Author: Alan M. Rathbun, PhD, MPH, Howard Hall Suite 200, 660 W. Redwood Street, University of Maryland School of Medicine, Baltimore, MD 21201. Email: arathbun@som.umaryland.edu
Alice S. Ryan
Department of Epidemiology and Public Health, Department of Medicine, University of Maryland Baltimore, School of Medicine, Baltimore, MD 21201; VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105; Department of Internal Medicine, University of Nebraska Medical Center, College of Medicine, Omaha, NE 68198; VA Maryland Health Care System, Baltimore, MD 21201; VA Portland Health Care System, Portland, OR 97239; Department of Medicine, Oregon Health & Science University, School of Medicine, Portland, OR 97239. Funding: This study was supported by the Rheumatology Research Foundation’s Scientist Development Award and grants from the National Institute on Aging (K01 AG064041, R01 AG048069, P30 AG028747), VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Conflicts of Interest: Dr. Alan M. Rathbun is supported by grants from the Rheumatology Research Foundation and National Institute on Aging (NIA; K01 AG064041). Dr. Bryant R. England and Ted R. Mikuls are supported by grants from the Rheumatology Research Foundation, VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Dr. Jennifer L. Barton is supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23 AR064372). Dr. Alice S. Ryan is supported by grants from the VA Rehabilitation Research and Development Service (N9273, I01 RX002790, I01 RX001461, I21 RX002870), NIA (P30 AG028747), and National Institute on Diabetes and Digestive and Kidney Disease (P30 DK072488). Dr. Michelle D. Shardell is supported by grants from NIA (R01 AG048069). Dr. Marc C. Hochberg is the President of Rheumcon Corporation and receives consulting fees from Bioiberica SA, Bristol-Myers Squibb, Eli Lilly, EMD Serono, Galapagos, IBSA Biotechniq SA, Novartis Pharma AG, Pfizer, Plexxikon, Samumed LLC, Theralogix LLC, and TissueGene Inc. Corresponding Author: Alan M. Rathbun, PhD, MPH, Howard Hall Suite 200, 660 W. Redwood Street, University of Maryland School of Medicine, Baltimore, MD 21201. Email: arathbun@som.umaryland.edu
Jennifer L. Barton
Department of Epidemiology and Public Health, Department of Medicine, University of Maryland Baltimore, School of Medicine, Baltimore, MD 21201; VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105; Department of Internal Medicine, University of Nebraska Medical Center, College of Medicine, Omaha, NE 68198; VA Maryland Health Care System, Baltimore, MD 21201; VA Portland Health Care System, Portland, OR 97239; Department of Medicine, Oregon Health & Science University, School of Medicine, Portland, OR 97239. Funding: This study was supported by the Rheumatology Research Foundation’s Scientist Development Award and grants from the National Institute on Aging (K01 AG064041, R01 AG048069, P30 AG028747), VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Conflicts of Interest: Dr. Alan M. Rathbun is supported by grants from the Rheumatology Research Foundation and National Institute on Aging (NIA; K01 AG064041). Dr. Bryant R. England and Ted R. Mikuls are supported by grants from the Rheumatology Research Foundation, VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Dr. Jennifer L. Barton is supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23 AR064372). Dr. Alice S. Ryan is supported by grants from the VA Rehabilitation Research and Development Service (N9273, I01 RX002790, I01 RX001461, I21 RX002870), NIA (P30 AG028747), and National Institute on Diabetes and Digestive and Kidney Disease (P30 DK072488). Dr. Michelle D. Shardell is supported by grants from NIA (R01 AG048069). Dr. Marc C. Hochberg is the President of Rheumcon Corporation and receives consulting fees from Bioiberica SA, Bristol-Myers Squibb, Eli Lilly, EMD Serono, Galapagos, IBSA Biotechniq SA, Novartis Pharma AG, Pfizer, Plexxikon, Samumed LLC, Theralogix LLC, and TissueGene Inc. Corresponding Author: Alan M. Rathbun, PhD, MPH, Howard Hall Suite 200, 660 W. Redwood Street, University of Maryland School of Medicine, Baltimore, MD 21201. Email: arathbun@som.umaryland.edu
Michelle D. Shardell
Department of Epidemiology and Public Health, Department of Medicine, University of Maryland Baltimore, School of Medicine, Baltimore, MD 21201; VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105; Department of Internal Medicine, University of Nebraska Medical Center, College of Medicine, Omaha, NE 68198; VA Maryland Health Care System, Baltimore, MD 21201; VA Portland Health Care System, Portland, OR 97239; Department of Medicine, Oregon Health & Science University, School of Medicine, Portland, OR 97239. Funding: This study was supported by the Rheumatology Research Foundation’s Scientist Development Award and grants from the National Institute on Aging (K01 AG064041, R01 AG048069, P30 AG028747), VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Conflicts of Interest: Dr. Alan M. Rathbun is supported by grants from the Rheumatology Research Foundation and National Institute on Aging (NIA; K01 AG064041). Dr. Bryant R. England and Ted R. Mikuls are supported by grants from the Rheumatology Research Foundation, VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Dr. Jennifer L. Barton is supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23 AR064372). Dr. Alice S. Ryan is supported by grants from the VA Rehabilitation Research and Development Service (N9273, I01 RX002790, I01 RX001461, I21 RX002870), NIA (P30 AG028747), and National Institute on Diabetes and Digestive and Kidney Disease (P30 DK072488). Dr. Michelle D. Shardell is supported by grants from NIA (R01 AG048069). Dr. Marc C. Hochberg is the President of Rheumcon Corporation and receives consulting fees from Bioiberica SA, Bristol-Myers Squibb, Eli Lilly, EMD Serono, Galapagos, IBSA Biotechniq SA, Novartis Pharma AG, Pfizer, Plexxikon, Samumed LLC, Theralogix LLC, and TissueGene Inc. Corresponding Author: Alan M. Rathbun, PhD, MPH, Howard Hall Suite 200, 660 W. Redwood Street, University of Maryland School of Medicine, Baltimore, MD 21201. Email: arathbun@som.umaryland.edu
Marc C. Hochberg
Department of Epidemiology and Public Health, Department of Medicine, University of Maryland Baltimore, School of Medicine, Baltimore, MD 21201; VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105; Department of Internal Medicine, University of Nebraska Medical Center, College of Medicine, Omaha, NE 68198; VA Maryland Health Care System, Baltimore, MD 21201; VA Portland Health Care System, Portland, OR 97239; Department of Medicine, Oregon Health & Science University, School of Medicine, Portland, OR 97239. Funding: This study was supported by the Rheumatology Research Foundation’s Scientist Development Award and grants from the National Institute on Aging (K01 AG064041, R01 AG048069, P30 AG028747), VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Conflicts of Interest: Dr. Alan M. Rathbun is supported by grants from the Rheumatology Research Foundation and National Institute on Aging (NIA; K01 AG064041). Dr. Bryant R. England and Ted R. Mikuls are supported by grants from the Rheumatology Research Foundation, VA Clinical Science Research and Development Service (I01 BX004660), and National Institute of General Medical Sciences (U54 GM115458). Dr. Jennifer L. Barton is supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23 AR064372). Dr. Alice S. Ryan is supported by grants from the VA Rehabilitation Research and Development Service (N9273, I01 RX002790, I01 RX001461, I21 RX002870), NIA (P30 AG028747), and National Institute on Diabetes and Digestive and Kidney Disease (P30 DK072488). Dr. Michelle D. Shardell is supported by grants from NIA (R01 AG048069). Dr. Marc C. Hochberg is the President of Rheumcon Corporation and receives consulting fees from Bioiberica SA, Bristol-Myers Squibb, Eli Lilly, EMD Serono, Galapagos, IBSA Biotechniq SA, Novartis Pharma AG, Pfizer, Plexxikon, Samumed LLC, Theralogix LLC, and TissueGene Inc. Corresponding Author: Alan M. Rathbun, PhD, MPH, Howard Hall Suite 200, 660 W. Redwood Street, University of Maryland School of Medicine, Baltimore, MD 21201. Email: arathbun@som.umaryland.edu
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Accepted manuscript
Relationship between Depression and Disease Activity in United States Veterans with Early Rheumatoid Arthritis Receiving Methotrexate
Alan M. Rathbun, Bryant R. England, Ted R. Mikuls, Alice S. Ryan, Jennifer L. Barton, Michelle D. Shardell, Marc C. Hochberg
The Journal of Rheumatology Nov 2020, jrheum.200743; DOI: 10.3899/jrheum.200743
Accepted manuscript
Relationship between Depression and Disease Activity in United States Veterans with Early Rheumatoid Arthritis Receiving Methotrexate
Alan M. Rathbun, Bryant R. England, Ted R. Mikuls, Alice S. Ryan, Jennifer L. Barton, Michelle D. Shardell, Marc C. Hochberg
The Journal of Rheumatology Nov 2020, jrheum.200743; DOI: 10.3899/jrheum.200743