Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • GDPR Policy
    • Accessibility
  • Contact Us
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on RSS
Research ArticleAccepted Article

Risk of osteoarthritis in an incident cohort of people with psoriatic arthritis: a population-based cohort study

Rachel Charlton, Amelia Green, Gavin Shaddick, Julia Snowball, Alison Nightingale, William Tillett, Catherine Smith and Neil McHugh on behalf of the PROMPT study group
The Journal of Rheumatology November 2020, jrheum.200564; DOI: https://doi.org/10.3899/jrheum.200564
Rachel Charlton
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK Department of mathematics, University of Exeter, UK Royal National Hospital for Rheumatic Diseases, Bath, UK Guys and St Thomas’ NHS Foundation Trust, UK. This report is independent research funded by the National Institute for Health Research, Programme Grants for Applied Research [Early detection to improve outcome in patients with undiagnosed PsA (‘PROMPT’), RP-PG-1212-20007]. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. All authors report grants from the National Institute for Health Research (RP-PG-1212-20007) during the conduct of the study. CS reports grants from the Medical Research Council (MR/L011808/1) outside the submitted work. Corresponding author: Professor Neil McHugh. Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. E-mail: n.j.mchugh@bath.ac.uk
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amelia Green
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK Department of mathematics, University of Exeter, UK Royal National Hospital for Rheumatic Diseases, Bath, UK Guys and St Thomas’ NHS Foundation Trust, UK. This report is independent research funded by the National Institute for Health Research, Programme Grants for Applied Research [Early detection to improve outcome in patients with undiagnosed PsA (‘PROMPT’), RP-PG-1212-20007]. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. All authors report grants from the National Institute for Health Research (RP-PG-1212-20007) during the conduct of the study. CS reports grants from the Medical Research Council (MR/L011808/1) outside the submitted work. Corresponding author: Professor Neil McHugh. Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. E-mail: n.j.mchugh@bath.ac.uk
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gavin Shaddick
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK Department of mathematics, University of Exeter, UK Royal National Hospital for Rheumatic Diseases, Bath, UK Guys and St Thomas’ NHS Foundation Trust, UK. This report is independent research funded by the National Institute for Health Research, Programme Grants for Applied Research [Early detection to improve outcome in patients with undiagnosed PsA (‘PROMPT’), RP-PG-1212-20007]. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. All authors report grants from the National Institute for Health Research (RP-PG-1212-20007) during the conduct of the study. CS reports grants from the Medical Research Council (MR/L011808/1) outside the submitted work. Corresponding author: Professor Neil McHugh. Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. E-mail: n.j.mchugh@bath.ac.uk
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julia Snowball
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK Department of mathematics, University of Exeter, UK Royal National Hospital for Rheumatic Diseases, Bath, UK Guys and St Thomas’ NHS Foundation Trust, UK. This report is independent research funded by the National Institute for Health Research, Programme Grants for Applied Research [Early detection to improve outcome in patients with undiagnosed PsA (‘PROMPT’), RP-PG-1212-20007]. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. All authors report grants from the National Institute for Health Research (RP-PG-1212-20007) during the conduct of the study. CS reports grants from the Medical Research Council (MR/L011808/1) outside the submitted work. Corresponding author: Professor Neil McHugh. Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. E-mail: n.j.mchugh@bath.ac.uk
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alison Nightingale
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK Department of mathematics, University of Exeter, UK Royal National Hospital for Rheumatic Diseases, Bath, UK Guys and St Thomas’ NHS Foundation Trust, UK. This report is independent research funded by the National Institute for Health Research, Programme Grants for Applied Research [Early detection to improve outcome in patients with undiagnosed PsA (‘PROMPT’), RP-PG-1212-20007]. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. All authors report grants from the National Institute for Health Research (RP-PG-1212-20007) during the conduct of the study. CS reports grants from the Medical Research Council (MR/L011808/1) outside the submitted work. Corresponding author: Professor Neil McHugh. Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. E-mail: n.j.mchugh@bath.ac.uk
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
William Tillett
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK Department of mathematics, University of Exeter, UK Royal National Hospital for Rheumatic Diseases, Bath, UK Guys and St Thomas’ NHS Foundation Trust, UK. This report is independent research funded by the National Institute for Health Research, Programme Grants for Applied Research [Early detection to improve outcome in patients with undiagnosed PsA (‘PROMPT’), RP-PG-1212-20007]. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. All authors report grants from the National Institute for Health Research (RP-PG-1212-20007) during the conduct of the study. CS reports grants from the Medical Research Council (MR/L011808/1) outside the submitted work. Corresponding author: Professor Neil McHugh. Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. E-mail: n.j.mchugh@bath.ac.uk
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Catherine Smith
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK Department of mathematics, University of Exeter, UK Royal National Hospital for Rheumatic Diseases, Bath, UK Guys and St Thomas’ NHS Foundation Trust, UK. This report is independent research funded by the National Institute for Health Research, Programme Grants for Applied Research [Early detection to improve outcome in patients with undiagnosed PsA (‘PROMPT’), RP-PG-1212-20007]. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. All authors report grants from the National Institute for Health Research (RP-PG-1212-20007) during the conduct of the study. CS reports grants from the Medical Research Council (MR/L011808/1) outside the submitted work. Corresponding author: Professor Neil McHugh. Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. E-mail: n.j.mchugh@bath.ac.uk
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Neil McHugh
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK Department of mathematics, University of Exeter, UK Royal National Hospital for Rheumatic Diseases, Bath, UK Guys and St Thomas’ NHS Foundation Trust, UK. This report is independent research funded by the National Institute for Health Research, Programme Grants for Applied Research [Early detection to improve outcome in patients with undiagnosed PsA (‘PROMPT’), RP-PG-1212-20007]. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. All authors report grants from the National Institute for Health Research (RP-PG-1212-20007) during the conduct of the study. CS reports grants from the Medical Research Council (MR/L011808/1) outside the submitted work. Corresponding author: Professor Neil McHugh. Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. E-mail: n.j.mchugh@bath.ac.uk
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • References
  • Info & Metrics
  • PDF
  • eLetters
PreviousNext
Loading

Abstract

Objective To determine the risk of a diagnosis of osteoarthritis (OA) in psoriatic arthritis (PsA) patients compared to patients with psoriasis and a general population cohort.

Methods Incident PsA patients aged 18-89 years at diagnosis were identified from the UK Clinical Practice Research Datalink between 1998 and 2014. All PsA patients were matched to two cohorts of patients both at a 1:4 ratio. The first cohort included patients with psoriasis (and no PsA) and the second was a general population cohort (with no psoriasis or PsA). The baseline prevalence of OA was calculated for each study cohort. The incidence of OA was calculated and adjusted relative risks (RRadj) were calculated using conditional Poisson regression.

Results We identified 6,783 incident PsA patients. The baseline prevalence of OA ranged from 22.1% (CI9521.1-23.1) in the PsA cohort to 12.6% (CI9512.2-13.0) and 11.0% (CI9510.6- 11.3) in the psoriasis and general population cohorts respectively. The incidence of OA was significantly higher in the PsA cohort compared to the psoriasis and general population cohorts after adjusting for BMI (RRadj 1.68 CI951.46-1.93 and RRadj 1.86 CI951.62-2.14 respectively).

Conclusion An increased risk of OA was observed in patients with PsA compared to patients with psoriasis alone and those in the general population. Further work is needed to determine whether this reflects a true increase in OA risk or misdiagnosed PsA and the extent to which it can be explained by differences in the opportunity for OA diagnosis between cohorts.

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

The Journal of Rheumatology
Vol. 48, Issue 4
1 Apr 2021
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Risk of osteoarthritis in an incident cohort of people with psoriatic arthritis: a population-based cohort study
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Accepted manuscript
Risk of osteoarthritis in an incident cohort of people with psoriatic arthritis: a population-based cohort study
Rachel Charlton, Amelia Green, Gavin Shaddick, Julia Snowball, Alison Nightingale, William Tillett, Catherine Smith, Neil McHugh
The Journal of Rheumatology Nov 2020, jrheum.200564; DOI: 10.3899/jrheum.200564

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
Accepted manuscript
Risk of osteoarthritis in an incident cohort of people with psoriatic arthritis: a population-based cohort study
Rachel Charlton, Amelia Green, Gavin Shaddick, Julia Snowball, Alison Nightingale, William Tillett, Catherine Smith, Neil McHugh
The Journal of Rheumatology Nov 2020, jrheum.200564; DOI: 10.3899/jrheum.200564
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Save to my folders

Jump to section

  • Article
  • References
  • Info & Metrics
  • PDF
  • eLetters

Related Articles

Cited By...

More in this TOC Section

  • Test-retest reliability for HAQ-DI and SF-36 PF for the measurement of physical function in psoriatic arthritis
  • Psoriasis characteristics for the early detection of psoriatic arthritis
  • Effects of denosumab in Japanese rheumatoid arthritis patients treated with conventional anti-rheumatic drugs: 36-month extension of a phase 3 study
Show more Accepted Article

Similar Articles

Content

  • First Release
  • Current
  • Archives
  • Collections
  • Audiovisual Rheum
  • COVID-19 and Rheumatology

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2016 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire