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Research ArticleAccepted Article

Risk of cancer in middle-aged patients with gout: A nationwide population-based study in Korea

Jung Sun Lee, Jisun Myung, Hyun Ah Lee, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Ji Seon Oh and Yong-Gil Kim
The Journal of Rheumatology November 2020, jrheum.200497; DOI: https://doi.org/10.3899/jrheum.200497
Jung Sun Lee
Division of Rheumatology, Department of Internal Medicine, Seoul Veterans Hospital, Seoul, Korea; Health Innovation Big Data Center, Asan Institute of Life Science, Asan Medical Center, Seoul, Korea; Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; Department of Information Medicine, Asan Medical Center, Seoul, Korea. This work was supported by a grant from the Asan Institute for Life Sciences, Asan Medical Centre, Korea [2020IP0025]. This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI19C0790). Corresponding author: Ji Seon Oh, MD, PhD Department of Information Medicine, Asan Medical Center, Seoul, Korea 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. E-mail: doogie55@naver.com
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Jisun Myung
Division of Rheumatology, Department of Internal Medicine, Seoul Veterans Hospital, Seoul, Korea; Health Innovation Big Data Center, Asan Institute of Life Science, Asan Medical Center, Seoul, Korea; Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; Department of Information Medicine, Asan Medical Center, Seoul, Korea. This work was supported by a grant from the Asan Institute for Life Sciences, Asan Medical Centre, Korea [2020IP0025]. This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI19C0790). Corresponding author: Ji Seon Oh, MD, PhD Department of Information Medicine, Asan Medical Center, Seoul, Korea 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. E-mail: doogie55@naver.com
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Hyun Ah Lee
Division of Rheumatology, Department of Internal Medicine, Seoul Veterans Hospital, Seoul, Korea; Health Innovation Big Data Center, Asan Institute of Life Science, Asan Medical Center, Seoul, Korea; Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; Department of Information Medicine, Asan Medical Center, Seoul, Korea. This work was supported by a grant from the Asan Institute for Life Sciences, Asan Medical Centre, Korea [2020IP0025]. This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI19C0790). Corresponding author: Ji Seon Oh, MD, PhD Department of Information Medicine, Asan Medical Center, Seoul, Korea 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. E-mail: doogie55@naver.com
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Seokchan Hong
Division of Rheumatology, Department of Internal Medicine, Seoul Veterans Hospital, Seoul, Korea; Health Innovation Big Data Center, Asan Institute of Life Science, Asan Medical Center, Seoul, Korea; Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; Department of Information Medicine, Asan Medical Center, Seoul, Korea. This work was supported by a grant from the Asan Institute for Life Sciences, Asan Medical Centre, Korea [2020IP0025]. This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI19C0790). Corresponding author: Ji Seon Oh, MD, PhD Department of Information Medicine, Asan Medical Center, Seoul, Korea 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. E-mail: doogie55@naver.com
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Chang-Keun Lee
Division of Rheumatology, Department of Internal Medicine, Seoul Veterans Hospital, Seoul, Korea; Health Innovation Big Data Center, Asan Institute of Life Science, Asan Medical Center, Seoul, Korea; Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; Department of Information Medicine, Asan Medical Center, Seoul, Korea. This work was supported by a grant from the Asan Institute for Life Sciences, Asan Medical Centre, Korea [2020IP0025]. This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI19C0790). Corresponding author: Ji Seon Oh, MD, PhD Department of Information Medicine, Asan Medical Center, Seoul, Korea 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. E-mail: doogie55@naver.com
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Bin Yoo
Division of Rheumatology, Department of Internal Medicine, Seoul Veterans Hospital, Seoul, Korea; Health Innovation Big Data Center, Asan Institute of Life Science, Asan Medical Center, Seoul, Korea; Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; Department of Information Medicine, Asan Medical Center, Seoul, Korea. This work was supported by a grant from the Asan Institute for Life Sciences, Asan Medical Centre, Korea [2020IP0025]. This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI19C0790). Corresponding author: Ji Seon Oh, MD, PhD Department of Information Medicine, Asan Medical Center, Seoul, Korea 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. E-mail: doogie55@naver.com
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Ji Seon Oh
Division of Rheumatology, Department of Internal Medicine, Seoul Veterans Hospital, Seoul, Korea; Health Innovation Big Data Center, Asan Institute of Life Science, Asan Medical Center, Seoul, Korea; Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; Department of Information Medicine, Asan Medical Center, Seoul, Korea. This work was supported by a grant from the Asan Institute for Life Sciences, Asan Medical Centre, Korea [2020IP0025]. This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI19C0790). Corresponding author: Ji Seon Oh, MD, PhD Department of Information Medicine, Asan Medical Center, Seoul, Korea 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. E-mail: doogie55@naver.com
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Yong-Gil Kim
Division of Rheumatology, Department of Internal Medicine, Seoul Veterans Hospital, Seoul, Korea; Health Innovation Big Data Center, Asan Institute of Life Science, Asan Medical Center, Seoul, Korea; Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; Department of Information Medicine, Asan Medical Center, Seoul, Korea. This work was supported by a grant from the Asan Institute for Life Sciences, Asan Medical Centre, Korea [2020IP0025]. This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI19C0790). Corresponding author: Ji Seon Oh, MD, PhD Department of Information Medicine, Asan Medical Center, Seoul, Korea 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. E-mail: doogie55@naver.com
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Abstract

Objective Gout is reportedly associated with a higher incidence of cancer. However, patients with gout tend to have several cancer-related factors including obesity, smoking, and alcohol consumption, thus, the precise association between gout and cancer risk remains unclear. We aimed to investigate the risk of cancer in Korean patients with gout.

Methods Based on the Korea Health Insurance Service database, the subjects comprised patients aged 41-55 years with gout newly diagnosed between 2003 and 2007. We used a multivariable-adjusted Cox-proportional hazard model in gout patients and a 1:2 ratio for the matched controls by age, sex, and index year.

Results We compared 4,176 patients with gout with 8,352 controls. The mean age and followup duration were 48.8 years and 10.1 years in both groups. Overall cancer risk was significantly different between gout patients and controls (HR 1.224, 95% CI 1.073–1.398). The all-cause mortality (HR 1.457, 95% CI 1.149–1.847) and cancer mortality (HR 1.470, 95% CI 1.020– 2.136) were higher in gout patients. In the subgroup analysis, the cancer risk of the stomach (HR 1.710, 95% CI 1.221–2.395), head and neck (HR 1.850, 95% CI 1.071–3.196), and hematologic or lymphoid organ (HR 2.849, 95% CI 1.035–7.844) was higher in gout patients.

Conclusion Patients aged 41–55 years with gout have a higher risk of cancer and all-cause and cancer mortality compared with the general population. Therefore, special attention should be paid to higher cancer risk and mortality in these patients who are diagnosed in middle age.

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The Journal of Rheumatology
Vol. 48, Issue 3
1 Mar 2021
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Accepted manuscript
Risk of cancer in middle-aged patients with gout: A nationwide population-based study in Korea
Jung Sun Lee, Jisun Myung, Hyun Ah Lee, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Ji Seon Oh, Yong-Gil Kim
The Journal of Rheumatology Nov 2020, jrheum.200497; DOI: 10.3899/jrheum.200497

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Accepted manuscript
Risk of cancer in middle-aged patients with gout: A nationwide population-based study in Korea
Jung Sun Lee, Jisun Myung, Hyun Ah Lee, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Ji Seon Oh, Yong-Gil Kim
The Journal of Rheumatology Nov 2020, jrheum.200497; DOI: 10.3899/jrheum.200497
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