Research ArticleArticle
Phenylalanine Is a Novel Marker for Radiographic Knee Osteoarthritis Progression: The MOST Study
Guangju Zhai, Xianbang Sun, Edward W. Randell, Ming Liu, Na Wang, Irina Tolstykh, Proton Rahman, James Torner, Cora E. Lewis, Michael C. Nevitt, Ali Guermazi, Frank Roemer and David T. Felson
The Journal of Rheumatology May 2020, jrheum.200054; DOI: https://doi.org/10.3899/jrheum.200054
Guangju Zhai
This study was supported by the Canadian Institutes of Health Research (FRN153298) and the original MOST study was supported by the National Institutes of Health and National Institute on Aging (Felson – U01 AG18820; Lewis – U01 AG18947; Nevitt – U01 AG19069; Torner – U01 AG18832). G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USA; E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USA; I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USA; P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA; C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USA; A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USA; D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Xianbang Sun
This study was supported by the Canadian Institutes of Health Research (FRN153298) and the original MOST study was supported by the National Institutes of Health and National Institute on Aging (Felson – U01 AG18820; Lewis – U01 AG18947; Nevitt – U01 AG19069; Torner – U01 AG18832). G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USA; E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USA; I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USA; P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA; C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USA; A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USA; D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Edward W. Randell
This study was supported by the Canadian Institutes of Health Research (FRN153298) and the original MOST study was supported by the National Institutes of Health and National Institute on Aging (Felson – U01 AG18820; Lewis – U01 AG18947; Nevitt – U01 AG19069; Torner – U01 AG18832). G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USA; E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USA; I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USA; P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA; C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USA; A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USA; D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Ming Liu
This study was supported by the Canadian Institutes of Health Research (FRN153298) and the original MOST study was supported by the National Institutes of Health and National Institute on Aging (Felson – U01 AG18820; Lewis – U01 AG18947; Nevitt – U01 AG19069; Torner – U01 AG18832). G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USA; E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USA; I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USA; P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA; C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USA; A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USA; D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Na Wang
This study was supported by the Canadian Institutes of Health Research (FRN153298) and the original MOST study was supported by the National Institutes of Health and National Institute on Aging (Felson – U01 AG18820; Lewis – U01 AG18947; Nevitt – U01 AG19069; Torner – U01 AG18832). G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USA; E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USA; I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USA; P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA; C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USA; A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USA; D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Irina Tolstykh
This study was supported by the Canadian Institutes of Health Research (FRN153298) and the original MOST study was supported by the National Institutes of Health and National Institute on Aging (Felson – U01 AG18820; Lewis – U01 AG18947; Nevitt – U01 AG19069; Torner – U01 AG18832). G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USA; E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USA; I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USA; P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA; C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USA; A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USA; D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Proton Rahman
This study was supported by the Canadian Institutes of Health Research (FRN153298) and the original MOST study was supported by the National Institutes of Health and National Institute on Aging (Felson – U01 AG18820; Lewis – U01 AG18947; Nevitt – U01 AG19069; Torner – U01 AG18832). G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USA; E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USA; I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USA; P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA; C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USA; A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USA; D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
James Torner
This study was supported by the Canadian Institutes of Health Research (FRN153298) and the original MOST study was supported by the National Institutes of Health and National Institute on Aging (Felson – U01 AG18820; Lewis – U01 AG18947; Nevitt – U01 AG19069; Torner – U01 AG18832). G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USA; E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USA; I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USA; P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA; C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USA; A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USA; D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Cora E. Lewis
This study was supported by the Canadian Institutes of Health Research (FRN153298) and the original MOST study was supported by the National Institutes of Health and National Institute on Aging (Felson – U01 AG18820; Lewis – U01 AG18947; Nevitt – U01 AG19069; Torner – U01 AG18832). G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USA; E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USA; I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USA; P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA; C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USA; A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USA; D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Michael C. Nevitt
This study was supported by the Canadian Institutes of Health Research (FRN153298) and the original MOST study was supported by the National Institutes of Health and National Institute on Aging (Felson – U01 AG18820; Lewis – U01 AG18947; Nevitt – U01 AG19069; Torner – U01 AG18832). G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USA; E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USA; I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USA; P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA; C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USA; A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USA; D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Ali Guermazi
This study was supported by the Canadian Institutes of Health Research (FRN153298) and the original MOST study was supported by the National Institutes of Health and National Institute on Aging (Felson – U01 AG18820; Lewis – U01 AG18947; Nevitt – U01 AG19069; Torner – U01 AG18832). G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USA; E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USA; I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USA; P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA; C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USA; A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USA; D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Frank Roemer
This study was supported by the Canadian Institutes of Health Research (FRN153298) and the original MOST study was supported by the National Institutes of Health and National Institute on Aging (Felson – U01 AG18820; Lewis – U01 AG18947; Nevitt – U01 AG19069; Torner – U01 AG18832). G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USA; E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USA; I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USA; P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA; C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USA; A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USA; D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
David T. Felson
This study was supported by the Canadian Institutes of Health Research (FRN153298) and the original MOST study was supported by the National Institutes of Health and National Institute on Aging (Felson – U01 AG18820; Lewis – U01 AG18947; Nevitt – U01 AG19069; Torner – U01 AG18832). G. Zhai, PhD, M. Liu, MSc, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; X. Sun, MS, Department of Rheumatology, Boston University School of Medicine, Boston, USA; E. Randell, PhD, Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; N. Wang, PhD, Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, USA; I. Tolstykh, MS, M.C. Nevitt, PhD, MPH, Epidemiology and Biostatistics, University of California, San Francisco, USA; P. Rahman, MD, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; J. Torner, PhD, Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA; C.E. Lewis, MD, Department of Epidemiology, University of Alabama, Birmingham, USA; A. Guermazi, MD, PhD, F. Roemer, MD, Department of Radiology, Boston University School of Medicine, Boston, USA; D.T. Felson, MD, MPH, Department of Rheumatology, Boston University School of Medicine, Boston, USA, and NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Phenylalanine Is a Novel Marker for Radiographic Knee Osteoarthritis Progression: The MOST Study
Guangju Zhai, Xianbang Sun, Edward W. Randell, Ming Liu, Na Wang, Irina Tolstykh, Proton Rahman, James Torner, Cora E. Lewis, Michael C. Nevitt, Ali Guermazi, Frank Roemer, David T. Felson
The Journal of Rheumatology May 2020, jrheum.200054; DOI: 10.3899/jrheum.200054
Phenylalanine Is a Novel Marker for Radiographic Knee Osteoarthritis Progression: The MOST Study
Guangju Zhai, Xianbang Sun, Edward W. Randell, Ming Liu, Na Wang, Irina Tolstykh, Proton Rahman, James Torner, Cora E. Lewis, Michael C. Nevitt, Ali Guermazi, Frank Roemer, David T. Felson
The Journal of Rheumatology May 2020, jrheum.200054; DOI: 10.3899/jrheum.200054