Research ArticleArticle
Flare Rate Thresholds for Patient Assessment of Disease Activity States in Gout
William Taylor, Nicola Dalbeth, Kenneth G. Saag, Jasvinder A. Singh, Elizabeth J. Rahn, Amy S. Mudano, Yi-Hsing Chen, Ching-Tsai Lin, Paul Tan, Worawit Louthreno, Janitzia Vazquez-Mellado, Hansel Hernández-Llinas, Tuhina Neogi, Ana B. Vargas-Santos, Geraldo Castelar-Pinheiro, Rodrigo B. Chaves-Amorim, Tillman Uhlig, Hilde B. Hammer, Maxim Eliseev, Fernando Perez-Ruiz, Lorenzo Cavagna, Geraldine M. McCarthy, Lisa K. Stamp, Martijin Gerritsen, Viktoria Fana, Francisca Sivera and Angelo L. Gaffo
The Journal of Rheumatology May 2020, jrheum.191242; DOI: https://doi.org/10.3899/jrheum.191242
William Taylor
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Nicola Dalbeth
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Kenneth G. Saag
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Jasvinder A. Singh
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Elizabeth J. Rahn
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Amy S. Mudano
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Yi-Hsing Chen
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Ching-Tsai Lin
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Paul Tan
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Worawit Louthreno
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Janitzia Vazquez-Mellado
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Hansel Hernández-Llinas
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Tuhina Neogi
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Ana B. Vargas-Santos
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Geraldo Castelar-Pinheiro
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Rodrigo B. Chaves-Amorim
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Tillman Uhlig
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Hilde B. Hammer
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Maxim Eliseev
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Fernando Perez-Ruiz
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Lorenzo Cavagna
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Geraldine M. McCarthy
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Lisa K. Stamp
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Martijin Gerritsen
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Viktoria Fana
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Francisca Sivera
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Angelo L. Gaffo
Funding for central study coordination and data analysis was provided by Ironwood Pharmaceuticals, which had had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication. Publication of this article was not contingent upon approval by Ironwood Pharmaceuticals. W. Taylor, MBChB, PhD, FRACP, FAFRM, University of Otago, Wellington, New Zealand; N. Dalbeth, MBChB, MD, FRACP, P. Tan, University of Auckland, Auckland, New Zealand; K.G. Saag, MD, MSc, E.J. Rahn, PhD, A.S. Mudano, MPH, University of Alabama at Birmingham, Birmingham, Alabama, USA; J.A. Singh, MD, MPH, A.L. Gaffo, MD, MSPH, University of Alabama at Birmingham, and Birmingham VA Medical Center, Birmingham, Alabama, USA; Y.H. Chen, MD, PhD, C.T. Lin, MD, Taichung Veterans General Hospital, Taichung, Taiwan; W. Louthreno, MD, Chiang Mai University, Chiang Mai, Thailand; J. Vazquez-Mellado, MD, PhD, H. Hernández-Llinas, MD, Hospital General de Mexico, Mexico City, Mexico; T. Neogi, MD, PhD, FRCPC, A.B. Vargas-Santos, MD, Boston University School of Medicine, Boston, Massachusetts, USA; G. Castelar-Pinheiro, MD, PhD, R.B. Chaves-Amorim, MD, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; T. Uhlig, MD, H.B. Hammer, MD, PhD, Diakonhjemmet Hospital, Oslo, Norway; M. Eliseev, PhD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; F. Perez-Ruiz, MD, PhD, Servicio de Reumatologia, Baracaldo, Spain; L. Cavagna, MD, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy; G.M. McCarthy, MD, FRCPI, Mater Misericordiae University Hospital, Dublin, Ireland; L.K. Stamp, MBChB, FRACP, PhD, University of Otago-Christchurch, Christchurch, New Zealand; M. Gerritsen, MD, PhD, Westfries Gasthuis, Hoorn, the Netherlands; V. Fana, MD, Copenhagen Center for Artritis Reserch, Righospitalet Glostrup, Denmark; 18F. Sivera, MD, PhD, Hospital General Universitario Elda, Elda, Spain. WT is a consultant for Pfizer, AstraZeneca, Abbvie, and Roche. ND receives grant/research support from AstraZeneca and Amgen; and is a consultant for Takeda, Pfizer, AstraZeneca, Horizon, and Kowa. KGS is a consultant for AstraZeneca, Horizon, Ironwood, SOBI, and Takeda. JAS has received consultant fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio Health, Medscape, WebMD, Clinical Care Options, Clearview Healthcare Partners, Putnam Associates, Spherix, Practice Point Communications, the National Institutes of Health, and the American College of Rheumatology (ACR); owns stock options in Amarin pharmaceuticals and Viking therapeutics; is on the speaker’s bureau of Simply Speaking; is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 12 companies; serves on the FDA Arthritis Advisory Committee; is a member of the Veterans Affairs Rheumatology Field Advisory Committee; is the editor and the Director of the University of Alabama at Birmingham Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis; and previously served as a member of the following committees: member, the ACR Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee, and the cochair of the ACR Criteria and Response Criteria subcommittee. LKS receives speaker fees from Amgen. AG is a consultant for SOBI and receives grant/research support from Amgen. Address correspondence to Associate Professor A. Gaffo, Shelby Biomedical Research Building 306, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: agaffo@uabmc.edu. Accepted for publication April 21, 2020.
Article Information
jrheum.191242
PubMed
Published By
Print ISSN
Online ISSN
Article Versions
- Latest version (May 1, 2020 - 04:00).
- You are currently viewing a Latest version of this article (November 15, 2020 - 04:00).
- View the most recent version of this article
Copyright & Usage
© 2020 The Journal of Rheumatology
Article usage
Statistics from Altmetric.com
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Flare Rate Thresholds for Patient Assessment of Disease Activity States in Gout
William Taylor, Nicola Dalbeth, Kenneth G. Saag, Jasvinder A. Singh, Elizabeth J. Rahn, Amy S. Mudano, Yi-Hsing Chen, Ching-Tsai Lin, Paul Tan, Worawit Louthreno, Janitzia Vazquez-Mellado, Hansel Hernández-Llinas, Tuhina Neogi, Ana B. Vargas-Santos, Geraldo Castelar-Pinheiro, Rodrigo B. Chaves-Amorim, Tillman Uhlig, Hilde B. Hammer, Maxim Eliseev, Fernando Perez-Ruiz, Lorenzo Cavagna, Geraldine M. McCarthy, Lisa K. Stamp, Martijin Gerritsen, Viktoria Fana, Francisca Sivera, Angelo L. Gaffo
The Journal of Rheumatology May 2020, jrheum.191242; DOI: 10.3899/jrheum.191242
Flare Rate Thresholds for Patient Assessment of Disease Activity States in Gout
William Taylor, Nicola Dalbeth, Kenneth G. Saag, Jasvinder A. Singh, Elizabeth J. Rahn, Amy S. Mudano, Yi-Hsing Chen, Ching-Tsai Lin, Paul Tan, Worawit Louthreno, Janitzia Vazquez-Mellado, Hansel Hernández-Llinas, Tuhina Neogi, Ana B. Vargas-Santos, Geraldo Castelar-Pinheiro, Rodrigo B. Chaves-Amorim, Tillman Uhlig, Hilde B. Hammer, Maxim Eliseev, Fernando Perez-Ruiz, Lorenzo Cavagna, Geraldine M. McCarthy, Lisa K. Stamp, Martijin Gerritsen, Viktoria Fana, Francisca Sivera, Angelo L. Gaffo
The Journal of Rheumatology May 2020, jrheum.191242; DOI: 10.3899/jrheum.191242