Research ArticleAccepted Article
Open Access
Relationship between Genetic Risk and Age of Diagnosis of Systemic Lupus Erythematosus
Daniela Dominguez, Sylvia Kamphuis, Joseph Beyene, Joan Wither, John B. Harley, Irene Blanco, Catarina Vila-Inda, Hermine Brunner, Marissa Klein-Gitleman, Deborah McCurdy, Dawn M. Wahezi, Thomas Lehman and Marija Jelusic
The Journal of Rheumatology October 2020, jrheum.200002; DOI: https://doi.org/10.3899/jrheum.200002
Daniela Dominguez
Division of Rheumatology, Hospital for Sick Children, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario; Division of Rheumatology Department of Pediatrics, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario; Division of Genetics and Development, Krembil Research Institute, Arthritis Centre of Excellence, Division of Rheumatology, Toronto Western Hospital, University Health Network, Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario; Center for Autoimmune Genomics and Etiology(CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Albert Einstein College of Medicine, Division of Rheumatology Bronx, NY; Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Pediaitric Rheumatology, University of California Los Angeles, Los Angeles, California; Children’s Hospital at Montefiore, Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, New York; Division of Pediatric Rheumatology, Hospital for Special Surgery New York, New York; Department of Pediatric Rheumatology, University of Zagreb School of Medicine, Croatia. Address correspondence to Earl Silverman MD FRCPC, Professor Emeritus of Pediatrics, Division of Rheumatology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5N 1R2. Email:earl.silverman@sickkids.ca
Sylvia Kamphuis
Division of Rheumatology, Hospital for Sick Children, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario; Division of Rheumatology Department of Pediatrics, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario; Division of Genetics and Development, Krembil Research Institute, Arthritis Centre of Excellence, Division of Rheumatology, Toronto Western Hospital, University Health Network, Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario; Center for Autoimmune Genomics and Etiology(CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Albert Einstein College of Medicine, Division of Rheumatology Bronx, NY; Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Pediaitric Rheumatology, University of California Los Angeles, Los Angeles, California; Children’s Hospital at Montefiore, Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, New York; Division of Pediatric Rheumatology, Hospital for Special Surgery New York, New York; Department of Pediatric Rheumatology, University of Zagreb School of Medicine, Croatia. Address correspondence to Earl Silverman MD FRCPC, Professor Emeritus of Pediatrics, Division of Rheumatology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5N 1R2. Email:earl.silverman@sickkids.ca
Joseph Beyene
Division of Rheumatology, Hospital for Sick Children, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario; Division of Rheumatology Department of Pediatrics, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario; Division of Genetics and Development, Krembil Research Institute, Arthritis Centre of Excellence, Division of Rheumatology, Toronto Western Hospital, University Health Network, Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario; Center for Autoimmune Genomics and Etiology(CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Albert Einstein College of Medicine, Division of Rheumatology Bronx, NY; Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Pediaitric Rheumatology, University of California Los Angeles, Los Angeles, California; Children’s Hospital at Montefiore, Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, New York; Division of Pediatric Rheumatology, Hospital for Special Surgery New York, New York; Department of Pediatric Rheumatology, University of Zagreb School of Medicine, Croatia. Address correspondence to Earl Silverman MD FRCPC, Professor Emeritus of Pediatrics, Division of Rheumatology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5N 1R2. Email:earl.silverman@sickkids.ca
Joan Wither
Division of Rheumatology, Hospital for Sick Children, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario; Division of Rheumatology Department of Pediatrics, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario; Division of Genetics and Development, Krembil Research Institute, Arthritis Centre of Excellence, Division of Rheumatology, Toronto Western Hospital, University Health Network, Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario; Center for Autoimmune Genomics and Etiology(CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Albert Einstein College of Medicine, Division of Rheumatology Bronx, NY; Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Pediaitric Rheumatology, University of California Los Angeles, Los Angeles, California; Children’s Hospital at Montefiore, Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, New York; Division of Pediatric Rheumatology, Hospital for Special Surgery New York, New York; Department of Pediatric Rheumatology, University of Zagreb School of Medicine, Croatia. Address correspondence to Earl Silverman MD FRCPC, Professor Emeritus of Pediatrics, Division of Rheumatology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5N 1R2. Email:earl.silverman@sickkids.ca
John B. Harley
Division of Rheumatology, Hospital for Sick Children, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario; Division of Rheumatology Department of Pediatrics, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario; Division of Genetics and Development, Krembil Research Institute, Arthritis Centre of Excellence, Division of Rheumatology, Toronto Western Hospital, University Health Network, Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario; Center for Autoimmune Genomics and Etiology(CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Albert Einstein College of Medicine, Division of Rheumatology Bronx, NY; Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Pediaitric Rheumatology, University of California Los Angeles, Los Angeles, California; Children’s Hospital at Montefiore, Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, New York; Division of Pediatric Rheumatology, Hospital for Special Surgery New York, New York; Department of Pediatric Rheumatology, University of Zagreb School of Medicine, Croatia. Address correspondence to Earl Silverman MD FRCPC, Professor Emeritus of Pediatrics, Division of Rheumatology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5N 1R2. Email:earl.silverman@sickkids.ca
Irene Blanco
Division of Rheumatology, Hospital for Sick Children, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario; Division of Rheumatology Department of Pediatrics, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario; Division of Genetics and Development, Krembil Research Institute, Arthritis Centre of Excellence, Division of Rheumatology, Toronto Western Hospital, University Health Network, Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario; Center for Autoimmune Genomics and Etiology(CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Albert Einstein College of Medicine, Division of Rheumatology Bronx, NY; Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Pediaitric Rheumatology, University of California Los Angeles, Los Angeles, California; Children’s Hospital at Montefiore, Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, New York; Division of Pediatric Rheumatology, Hospital for Special Surgery New York, New York; Department of Pediatric Rheumatology, University of Zagreb School of Medicine, Croatia. Address correspondence to Earl Silverman MD FRCPC, Professor Emeritus of Pediatrics, Division of Rheumatology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5N 1R2. Email:earl.silverman@sickkids.ca
Catarina Vila-Inda
Division of Rheumatology, Hospital for Sick Children, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario; Division of Rheumatology Department of Pediatrics, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario; Division of Genetics and Development, Krembil Research Institute, Arthritis Centre of Excellence, Division of Rheumatology, Toronto Western Hospital, University Health Network, Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario; Center for Autoimmune Genomics and Etiology(CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Albert Einstein College of Medicine, Division of Rheumatology Bronx, NY; Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Pediaitric Rheumatology, University of California Los Angeles, Los Angeles, California; Children’s Hospital at Montefiore, Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, New York; Division of Pediatric Rheumatology, Hospital for Special Surgery New York, New York; Department of Pediatric Rheumatology, University of Zagreb School of Medicine, Croatia. Address correspondence to Earl Silverman MD FRCPC, Professor Emeritus of Pediatrics, Division of Rheumatology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5N 1R2. Email:earl.silverman@sickkids.ca
Hermine Brunner
Division of Rheumatology, Hospital for Sick Children, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario; Division of Rheumatology Department of Pediatrics, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario; Division of Genetics and Development, Krembil Research Institute, Arthritis Centre of Excellence, Division of Rheumatology, Toronto Western Hospital, University Health Network, Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario; Center for Autoimmune Genomics and Etiology(CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Albert Einstein College of Medicine, Division of Rheumatology Bronx, NY; Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Pediaitric Rheumatology, University of California Los Angeles, Los Angeles, California; Children’s Hospital at Montefiore, Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, New York; Division of Pediatric Rheumatology, Hospital for Special Surgery New York, New York; Department of Pediatric Rheumatology, University of Zagreb School of Medicine, Croatia. Address correspondence to Earl Silverman MD FRCPC, Professor Emeritus of Pediatrics, Division of Rheumatology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5N 1R2. Email:earl.silverman@sickkids.ca
Marissa Klein-Gitleman
Division of Rheumatology, Hospital for Sick Children, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario; Division of Rheumatology Department of Pediatrics, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario; Division of Genetics and Development, Krembil Research Institute, Arthritis Centre of Excellence, Division of Rheumatology, Toronto Western Hospital, University Health Network, Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario; Center for Autoimmune Genomics and Etiology(CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Albert Einstein College of Medicine, Division of Rheumatology Bronx, NY; Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Pediaitric Rheumatology, University of California Los Angeles, Los Angeles, California; Children’s Hospital at Montefiore, Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, New York; Division of Pediatric Rheumatology, Hospital for Special Surgery New York, New York; Department of Pediatric Rheumatology, University of Zagreb School of Medicine, Croatia. Address correspondence to Earl Silverman MD FRCPC, Professor Emeritus of Pediatrics, Division of Rheumatology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5N 1R2. Email:earl.silverman@sickkids.ca
Deborah McCurdy
Division of Rheumatology, Hospital for Sick Children, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario; Division of Rheumatology Department of Pediatrics, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario; Division of Genetics and Development, Krembil Research Institute, Arthritis Centre of Excellence, Division of Rheumatology, Toronto Western Hospital, University Health Network, Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario; Center for Autoimmune Genomics and Etiology(CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Albert Einstein College of Medicine, Division of Rheumatology Bronx, NY; Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Pediaitric Rheumatology, University of California Los Angeles, Los Angeles, California; Children’s Hospital at Montefiore, Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, New York; Division of Pediatric Rheumatology, Hospital for Special Surgery New York, New York; Department of Pediatric Rheumatology, University of Zagreb School of Medicine, Croatia. Address correspondence to Earl Silverman MD FRCPC, Professor Emeritus of Pediatrics, Division of Rheumatology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5N 1R2. Email:earl.silverman@sickkids.ca
Dawn M. Wahezi
Division of Rheumatology, Hospital for Sick Children, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario; Division of Rheumatology Department of Pediatrics, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario; Division of Genetics and Development, Krembil Research Institute, Arthritis Centre of Excellence, Division of Rheumatology, Toronto Western Hospital, University Health Network, Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario; Center for Autoimmune Genomics and Etiology(CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Albert Einstein College of Medicine, Division of Rheumatology Bronx, NY; Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Pediaitric Rheumatology, University of California Los Angeles, Los Angeles, California; Children’s Hospital at Montefiore, Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, New York; Division of Pediatric Rheumatology, Hospital for Special Surgery New York, New York; Department of Pediatric Rheumatology, University of Zagreb School of Medicine, Croatia. Address correspondence to Earl Silverman MD FRCPC, Professor Emeritus of Pediatrics, Division of Rheumatology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5N 1R2. Email:earl.silverman@sickkids.ca
Thomas Lehman
Division of Rheumatology, Hospital for Sick Children, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario; Division of Rheumatology Department of Pediatrics, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario; Division of Genetics and Development, Krembil Research Institute, Arthritis Centre of Excellence, Division of Rheumatology, Toronto Western Hospital, University Health Network, Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario; Center for Autoimmune Genomics and Etiology(CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Albert Einstein College of Medicine, Division of Rheumatology Bronx, NY; Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Pediaitric Rheumatology, University of California Los Angeles, Los Angeles, California; Children’s Hospital at Montefiore, Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, New York; Division of Pediatric Rheumatology, Hospital for Special Surgery New York, New York; Department of Pediatric Rheumatology, University of Zagreb School of Medicine, Croatia. Address correspondence to Earl Silverman MD FRCPC, Professor Emeritus of Pediatrics, Division of Rheumatology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5N 1R2. Email:earl.silverman@sickkids.ca
Marija Jelusic
Division of Rheumatology, Hospital for Sick Children, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Ontario; Division of Rheumatology Department of Pediatrics, Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands; Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario; Division of Genetics and Development, Krembil Research Institute, Arthritis Centre of Excellence, Division of Rheumatology, Toronto Western Hospital, University Health Network, Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario; Center for Autoimmune Genomics and Etiology(CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Albert Einstein College of Medicine, Division of Rheumatology Bronx, NY; Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Pediaitric Rheumatology, University of California Los Angeles, Los Angeles, California; Children’s Hospital at Montefiore, Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, New York; Division of Pediatric Rheumatology, Hospital for Special Surgery New York, New York; Department of Pediatric Rheumatology, University of Zagreb School of Medicine, Croatia. Address correspondence to Earl Silverman MD FRCPC, Professor Emeritus of Pediatrics, Division of Rheumatology, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5N 1R2. Email:earl.silverman@sickkids.ca
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Accepted manuscript
Relationship between Genetic Risk and Age of Diagnosis of Systemic Lupus Erythematosus
Daniela Dominguez, Sylvia Kamphuis, Joseph Beyene, Joan Wither, John B. Harley, Irene Blanco, Catarina Vila-Inda, Hermine Brunner, Marissa Klein-Gitleman, Deborah McCurdy, Dawn M. Wahezi, Thomas Lehman, Marija Jelusic
The Journal of Rheumatology Oct 2020, jrheum.200002; DOI: 10.3899/jrheum.200002
Accepted manuscript
Relationship between Genetic Risk and Age of Diagnosis of Systemic Lupus Erythematosus
Daniela Dominguez, Sylvia Kamphuis, Joseph Beyene, Joan Wither, John B. Harley, Irene Blanco, Catarina Vila-Inda, Hermine Brunner, Marissa Klein-Gitleman, Deborah McCurdy, Dawn M. Wahezi, Thomas Lehman, Marija Jelusic
The Journal of Rheumatology Oct 2020, jrheum.200002; DOI: 10.3899/jrheum.200002