LetterLetter
Urinary N-telopeptide as a Biomarker of Disease Activity in Patients with Chronic Nonbacterial Osteomyelitis Who Have Not Received Bisphosphonates
Alexandra Perkins, Anne Stevens, Polly M. Ferguson and Yongdong Zhao
The Journal of Rheumatology October 2020, jrheum.191098; DOI: https://doi.org/10.3899/jrheum.191098
Alexandra Perkins
University of Washington School of Medicine, Seattle, Washington; Seattle Children’s Hospital, Seattle, Washington, and Janssen Research & Development, LLC, Spring House, Pennsylvania; University of Iowa Carver College of Medicine, Iowa City, Iowa; Seattle Children’s Hospital and Clinical and Translational Research Center, Seattle, Washington, USA. This study is supported by The Childhood Arthritis and Rheumatology Research Alliance (CARRA), the Arthritis Foundation Small Grants program, and the Chronic Recurrent Multifocal Osteomyelitis (CRMO) Research Fund at the University of Iowa. PJF is supported by R01 AR059703 and by the Marjorie K. Lamb Professorship. YZ received research support from CARRA and Bristol-Myers Squibb. Address correspondence to Dr. Y. Zhao4, 4800 Sand Point Way NE, Seattle, WA 98105, USA. Email: yongdong.zhao@seattlechildrens.org.
Anne Stevens
University of Washington School of Medicine, Seattle, Washington; Seattle Children’s Hospital, Seattle, Washington, and Janssen Research & Development, LLC, Spring House, Pennsylvania; University of Iowa Carver College of Medicine, Iowa City, Iowa; Seattle Children’s Hospital and Clinical and Translational Research Center, Seattle, Washington, USA. This study is supported by The Childhood Arthritis and Rheumatology Research Alliance (CARRA), the Arthritis Foundation Small Grants program, and the Chronic Recurrent Multifocal Osteomyelitis (CRMO) Research Fund at the University of Iowa. PJF is supported by R01 AR059703 and by the Marjorie K. Lamb Professorship. YZ received research support from CARRA and Bristol-Myers Squibb. Address correspondence to Dr. Y. Zhao4, 4800 Sand Point Way NE, Seattle, WA 98105, USA. Email: yongdong.zhao@seattlechildrens.org.
Polly M. Ferguson
University of Washington School of Medicine, Seattle, Washington; Seattle Children’s Hospital, Seattle, Washington, and Janssen Research & Development, LLC, Spring House, Pennsylvania; University of Iowa Carver College of Medicine, Iowa City, Iowa; Seattle Children’s Hospital and Clinical and Translational Research Center, Seattle, Washington, USA. This study is supported by The Childhood Arthritis and Rheumatology Research Alliance (CARRA), the Arthritis Foundation Small Grants program, and the Chronic Recurrent Multifocal Osteomyelitis (CRMO) Research Fund at the University of Iowa. PJF is supported by R01 AR059703 and by the Marjorie K. Lamb Professorship. YZ received research support from CARRA and Bristol-Myers Squibb. Address correspondence to Dr. Y. Zhao4, 4800 Sand Point Way NE, Seattle, WA 98105, USA. Email: yongdong.zhao@seattlechildrens.org.
Yongdong Zhao
University of Washington School of Medicine, Seattle, Washington; Seattle Children’s Hospital, Seattle, Washington, and Janssen Research & Development, LLC, Spring House, Pennsylvania; University of Iowa Carver College of Medicine, Iowa City, Iowa; Seattle Children’s Hospital and Clinical and Translational Research Center, Seattle, Washington, USA. This study is supported by The Childhood Arthritis and Rheumatology Research Alliance (CARRA), the Arthritis Foundation Small Grants program, and the Chronic Recurrent Multifocal Osteomyelitis (CRMO) Research Fund at the University of Iowa. PJF is supported by R01 AR059703 and by the Marjorie K. Lamb Professorship. YZ received research support from CARRA and Bristol-Myers Squibb. Address correspondence to Dr. Y. Zhao4, 4800 Sand Point Way NE, Seattle, WA 98105, USA. Email: yongdong.zhao@seattlechildrens.org.
Abstract
Chronic nonbacterial osteomyelitis (CNO) is a rare autoinflammatory disease that causes bone destruction, soft tissue swelling, and bone pain1. Diagnosis and treatment are hindered by a lack of a reliable laboratory test to assess disease activity. Bone inflammation in CNO is associated with increased osteoclastic activity and bone resorption, causing focal accelerated breakdown of bone collagen.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Urinary N-telopeptide as a Biomarker of Disease Activity in Patients with Chronic Nonbacterial Osteomyelitis Who Have Not Received Bisphosphonates
Alexandra Perkins, Anne Stevens, Polly M. Ferguson, Yongdong Zhao
The Journal of Rheumatology Oct 2020, jrheum.191098; DOI: 10.3899/jrheum.191098