Research ArticleArticle
Longterm Outcomes of Temporomandibular Joints in Juvenile Idiopathic Arthritis: 17 Years of Followup of a Nordic Juvenile Idiopathic Arthritis Cohort
Mia Glerup, Peter Stoustrup, Louise H. Matzen, Veronika Rypdal, Ellen Nordal, Paula Frid, Ellen Dalen Arnstad, Marite Rygg, Olafur Thorarensen, Maria Ekelund, Lillemor Berntson, Anders Fasth, Håkan Nilsson, Suvi Peltoniemi, Kristiina Aalto, Sirpa Arte, Peter Toftedal, Susan Nielsen, Sven Kreiborg, Troels Herlin and Thomas Klit Pedersen
The Journal of Rheumatology September 2019, jrheum.190231; DOI: https://doi.org/10.3899/jrheum.190231
Mia Glerup
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Peter Stoustrup
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Louise H. Matzen
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Veronika Rypdal
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Ellen Nordal
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Paula Frid
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Ellen Dalen Arnstad
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Marite Rygg
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Olafur Thorarensen
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Maria Ekelund
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Lillemor Berntson
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Anders Fasth
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Håkan Nilsson
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Suvi Peltoniemi
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Kristiina Aalto
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Sirpa Arte
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Peter Toftedal
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Susan Nielsen
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Sven Kreiborg
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Troels Herlin
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Thomas Klit Pedersen
From the Department of Pediatrics, Aarhus University Hospital; Section of Orthodontics, Aarhus University; Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark; Department of Pediatrics, University Hospital of North Norway, Tromsø; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø; Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway, Tromsø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; Department of Pediatrics, St. Olavs Hospital, Trondheim; Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital, Trondheim, Norway; Department of Pediatrics, Ryhov County Hospital, Jönköping; Department of Women’s and Children’s Health, Uppsala University, Uppsala; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jönköping, Sweden; Hospital for Children and Adolescents, University of Helsinki, Helsinki; Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Pediatrics, Copenhagen University Hospital, Copenhagen; Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen, Copenhagen; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark. M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Stoustrup, Associate Professor, DDS, PhD, Section of Orthodontics, Aarhus University; L.H. Matzen, DDS, PhD, Associate Professor, Section of Oral Radiology, Department of Dentistry and Oral Health, Aarhus University; V. Rypdal, MD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; E. Nordal, MD, PhD, Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway; P. Frid, DDS, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, and Department of Otorhinolaryngology and Department and Division of Oral and Maxillofacial Surgery, University Hospital North Norway and Public Dental Service Competence Center of North Norway; E.D. Arnstad, MD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust; M. Rygg, MD, Professor, PhD, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, and Department of Pediatrics, St. Olavs Hospital; O. Thorarensen, DDS, Department of Oral and Craniomaxillofacial Surgery, St. Olavs Hospital; M. Ekelund, MD, Department of Pediatrics, Ryhov County Hospital, and Department of Women’s and Children’s Health, Uppsala University; L. Berntson, MD, PhD, Department of Women’s and Children’s Health, Uppsala University; A. Fasth, MD, PhD, Professor, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg; H. Nilsson, DDS, PhD, Dr. Odont, Department of Oral and Maxillofacial Surgery/Stomatognathic Physiology, The Institute for Postgraduate Dental Education; S. Peltoniemi, MD, Hospital for Children and Adolescents, University of Helsinki; K. Aalto, MD, PhD, Hospital for Children and Adolescents, University of Helsinki; S. Arte, DDS, PhD, Orthodontics, Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital; P. Toftedal, MD, PhD, Department of Pediatrics, Copenhagen University Hospital; S. Nielsen, MD, Department of Pediatrics, Copenhagen University Hospital; S. Kreiborg, Professor, DDS, PhD, Dr. Odont, Department of Pediatric Dentistry and Clinical Genetics, University of Copenhagen; T. Herlin, Professor, MD, DMSc, Department of Pediatrics, Aarhus University Hospital; T.K. Pedersen, Professor, DDS, PhD, Section of Orthodontics, Aarhus University, and Department of Oral and Maxillofacial Surgery, Aarhus University Hospital. Address correspondence to Dr. M. Glerup, Department of Pediatrics, Aarhus University Hospital, Skejby, Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark. E-mail: miagleru@rm.dk. Accepted for publication September 3, 2019.
Abstract
Objective To determine the prevalence of orofacial symptoms, dysfunctions, and deformities of the temporomandibular joint (TMJ) in juvenile idiopathic arthritis (JIA) 17 years after disease onset.
Methods Drawn from a prospective, population-based Nordic JIA cohort with disease onset from 1997 to 2000, 420 consecutive cases were eligible for orofacial evaluation of TMJ involvement. The followup visit included demographic data, a standardized clinical orofacial examination, and full-face cone-beam computed tomography (CBCT). For comparison, 200 age-matched healthy controls were used.
Results Of 420 eligible participants with JIA, 265 (63%) were included (mean age 23.5 ± 4.2 yrs) and completed a standardized clinical orofacial examination. Of these, 245 had a full-face CBCT performed. At least 1 orofacial symptom was reported by 33%. Compared to controls, the JIA group significantly more often reported TMJ pain, TMJ morning stiffness, and limitation on chewing. Further, among participants reporting complaints, the number of symptoms was also higher in JIA. The mean maximal incisal opening was lower in the JIA group (p < 0.001), and TMJ pain on palpation was more frequent. Condylar deformities and/or erosions were observed in 61% as assessed by CBCT, showing bilateral changes in about 70%. Risk factors of condylar deformities were orofacial dysfunction or biologic treatment; enthesitis-related arthritis was protective.
Conclusion This study of the longterm consequences of TMJ involvement in a population-based JIA cohort reports persistence of comprehensive symptoms, dysfunctions, and damage of the TMJ into adulthood. We suggest interdisciplinary followup of JIA patients also in adulthood.
In this issue
The Journal of Rheumatology
Vol. 49, Issue 8
1 Aug 2022
Longterm Outcomes of Temporomandibular Joints in Juvenile Idiopathic Arthritis: 17 Years of Followup of a Nordic Juvenile Idiopathic Arthritis Cohort
Mia Glerup, Peter Stoustrup, Louise H. Matzen, Veronika Rypdal, Ellen Nordal, Paula Frid, Ellen Dalen Arnstad, Marite Rygg, Olafur Thorarensen, Maria Ekelund, Lillemor Berntson, Anders Fasth, Håkan Nilsson, Suvi Peltoniemi, Kristiina Aalto, Sirpa Arte, Peter Toftedal, Susan Nielsen, Sven Kreiborg, Troels Herlin, Thomas Klit Pedersen
The Journal of Rheumatology Sep 2019, jrheum.190231; DOI: 10.3899/jrheum.190231
Longterm Outcomes of Temporomandibular Joints in Juvenile Idiopathic Arthritis: 17 Years of Followup of a Nordic Juvenile Idiopathic Arthritis Cohort
Mia Glerup, Peter Stoustrup, Louise H. Matzen, Veronika Rypdal, Ellen Nordal, Paula Frid, Ellen Dalen Arnstad, Marite Rygg, Olafur Thorarensen, Maria Ekelund, Lillemor Berntson, Anders Fasth, Håkan Nilsson, Suvi Peltoniemi, Kristiina Aalto, Sirpa Arte, Peter Toftedal, Susan Nielsen, Sven Kreiborg, Troels Herlin, Thomas Klit Pedersen
The Journal of Rheumatology Sep 2019, jrheum.190231; DOI: 10.3899/jrheum.190231
