Research ArticleArticle
Sleep Quality and Fatigue Are Associated with Pain Exacerbations of Hip Osteoarthritis: An Internet-based Case-crossover Study
Kai Fu, Joanna Makovey, Ben Metcalf, Kim L. Bennell, Yuqing Zhang, Rebecca Asher, Sarah R. Robbins, Leticia A. Deveza, Peter A. Cistulli and David J. Hunter
The Journal of Rheumatology April 2019, jrheum.181406; DOI: https://doi.org/10.3899/jrheum.181406
Kai Fu
From the Kolling Institute of Medical Research, Institute of Bone and Joint Research; Department of Rheumatology, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, New South Wales; Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Victoria, Australia; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA; National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney; Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. Supported by NHMRC program grant APP631717. Dr. Hunter is supported by an NHMRC Practitioner Fellowship. Dr. Bennell is supported by an NHMRC Principal Research Fellowship. Mr. Fu received a scholarship from the China Scholarship Council. K. Fu, MBBS, Mch, PhD Candidate, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; J. Makovey, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; B. Metcalf, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; K.L. Bennell, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; Y. Zhang, DSc, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine; R. Asher, PhD, NHMRC Clinical Trials Centre, University of Sydney; S.R. Robbins, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; L.A. Deveza, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; P.A. Cistulli, PhD, Charles Perkins Centre, Sydney Medical School, University of Sydney, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney; D.J. Hunter, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney. Address correspondence to K. Fu, Institute of Bone and Joint Research, Level 10, Kolling Building, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia. E-mail: kafu7690@uni.sydney.edu.au. Accepted for publication March 19, 2019.
Joanna Makovey
From the Kolling Institute of Medical Research, Institute of Bone and Joint Research; Department of Rheumatology, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, New South Wales; Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Victoria, Australia; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA; National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney; Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. Supported by NHMRC program grant APP631717. Dr. Hunter is supported by an NHMRC Practitioner Fellowship. Dr. Bennell is supported by an NHMRC Principal Research Fellowship. Mr. Fu received a scholarship from the China Scholarship Council. K. Fu, MBBS, Mch, PhD Candidate, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; J. Makovey, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; B. Metcalf, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; K.L. Bennell, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; Y. Zhang, DSc, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine; R. Asher, PhD, NHMRC Clinical Trials Centre, University of Sydney; S.R. Robbins, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; L.A. Deveza, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; P.A. Cistulli, PhD, Charles Perkins Centre, Sydney Medical School, University of Sydney, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney; D.J. Hunter, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney. Address correspondence to K. Fu, Institute of Bone and Joint Research, Level 10, Kolling Building, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia. E-mail: kafu7690@uni.sydney.edu.au. Accepted for publication March 19, 2019.
Ben Metcalf
From the Kolling Institute of Medical Research, Institute of Bone and Joint Research; Department of Rheumatology, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, New South Wales; Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Victoria, Australia; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA; National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney; Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. Supported by NHMRC program grant APP631717. Dr. Hunter is supported by an NHMRC Practitioner Fellowship. Dr. Bennell is supported by an NHMRC Principal Research Fellowship. Mr. Fu received a scholarship from the China Scholarship Council. K. Fu, MBBS, Mch, PhD Candidate, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; J. Makovey, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; B. Metcalf, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; K.L. Bennell, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; Y. Zhang, DSc, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine; R. Asher, PhD, NHMRC Clinical Trials Centre, University of Sydney; S.R. Robbins, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; L.A. Deveza, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; P.A. Cistulli, PhD, Charles Perkins Centre, Sydney Medical School, University of Sydney, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney; D.J. Hunter, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney. Address correspondence to K. Fu, Institute of Bone and Joint Research, Level 10, Kolling Building, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia. E-mail: kafu7690@uni.sydney.edu.au. Accepted for publication March 19, 2019.
Kim L. Bennell
From the Kolling Institute of Medical Research, Institute of Bone and Joint Research; Department of Rheumatology, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, New South Wales; Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Victoria, Australia; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA; National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney; Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. Supported by NHMRC program grant APP631717. Dr. Hunter is supported by an NHMRC Practitioner Fellowship. Dr. Bennell is supported by an NHMRC Principal Research Fellowship. Mr. Fu received a scholarship from the China Scholarship Council. K. Fu, MBBS, Mch, PhD Candidate, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; J. Makovey, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; B. Metcalf, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; K.L. Bennell, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; Y. Zhang, DSc, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine; R. Asher, PhD, NHMRC Clinical Trials Centre, University of Sydney; S.R. Robbins, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; L.A. Deveza, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; P.A. Cistulli, PhD, Charles Perkins Centre, Sydney Medical School, University of Sydney, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney; D.J. Hunter, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney. Address correspondence to K. Fu, Institute of Bone and Joint Research, Level 10, Kolling Building, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia. E-mail: kafu7690@uni.sydney.edu.au. Accepted for publication March 19, 2019.
Yuqing Zhang
From the Kolling Institute of Medical Research, Institute of Bone and Joint Research; Department of Rheumatology, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, New South Wales; Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Victoria, Australia; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA; National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney; Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. Supported by NHMRC program grant APP631717. Dr. Hunter is supported by an NHMRC Practitioner Fellowship. Dr. Bennell is supported by an NHMRC Principal Research Fellowship. Mr. Fu received a scholarship from the China Scholarship Council. K. Fu, MBBS, Mch, PhD Candidate, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; J. Makovey, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; B. Metcalf, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; K.L. Bennell, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; Y. Zhang, DSc, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine; R. Asher, PhD, NHMRC Clinical Trials Centre, University of Sydney; S.R. Robbins, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; L.A. Deveza, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; P.A. Cistulli, PhD, Charles Perkins Centre, Sydney Medical School, University of Sydney, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney; D.J. Hunter, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney. Address correspondence to K. Fu, Institute of Bone and Joint Research, Level 10, Kolling Building, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia. E-mail: kafu7690@uni.sydney.edu.au. Accepted for publication March 19, 2019.
Rebecca Asher
From the Kolling Institute of Medical Research, Institute of Bone and Joint Research; Department of Rheumatology, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, New South Wales; Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Victoria, Australia; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA; National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney; Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. Supported by NHMRC program grant APP631717. Dr. Hunter is supported by an NHMRC Practitioner Fellowship. Dr. Bennell is supported by an NHMRC Principal Research Fellowship. Mr. Fu received a scholarship from the China Scholarship Council. K. Fu, MBBS, Mch, PhD Candidate, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; J. Makovey, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; B. Metcalf, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; K.L. Bennell, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; Y. Zhang, DSc, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine; R. Asher, PhD, NHMRC Clinical Trials Centre, University of Sydney; S.R. Robbins, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; L.A. Deveza, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; P.A. Cistulli, PhD, Charles Perkins Centre, Sydney Medical School, University of Sydney, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney; D.J. Hunter, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney. Address correspondence to K. Fu, Institute of Bone and Joint Research, Level 10, Kolling Building, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia. E-mail: kafu7690@uni.sydney.edu.au. Accepted for publication March 19, 2019.
Sarah R. Robbins
From the Kolling Institute of Medical Research, Institute of Bone and Joint Research; Department of Rheumatology, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, New South Wales; Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Victoria, Australia; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA; National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney; Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. Supported by NHMRC program grant APP631717. Dr. Hunter is supported by an NHMRC Practitioner Fellowship. Dr. Bennell is supported by an NHMRC Principal Research Fellowship. Mr. Fu received a scholarship from the China Scholarship Council. K. Fu, MBBS, Mch, PhD Candidate, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; J. Makovey, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; B. Metcalf, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; K.L. Bennell, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; Y. Zhang, DSc, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine; R. Asher, PhD, NHMRC Clinical Trials Centre, University of Sydney; S.R. Robbins, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; L.A. Deveza, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; P.A. Cistulli, PhD, Charles Perkins Centre, Sydney Medical School, University of Sydney, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney; D.J. Hunter, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney. Address correspondence to K. Fu, Institute of Bone and Joint Research, Level 10, Kolling Building, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia. E-mail: kafu7690@uni.sydney.edu.au. Accepted for publication March 19, 2019.
Leticia A. Deveza
From the Kolling Institute of Medical Research, Institute of Bone and Joint Research; Department of Rheumatology, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, New South Wales; Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Victoria, Australia; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA; National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney; Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. Supported by NHMRC program grant APP631717. Dr. Hunter is supported by an NHMRC Practitioner Fellowship. Dr. Bennell is supported by an NHMRC Principal Research Fellowship. Mr. Fu received a scholarship from the China Scholarship Council. K. Fu, MBBS, Mch, PhD Candidate, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; J. Makovey, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; B. Metcalf, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; K.L. Bennell, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; Y. Zhang, DSc, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine; R. Asher, PhD, NHMRC Clinical Trials Centre, University of Sydney; S.R. Robbins, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; L.A. Deveza, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; P.A. Cistulli, PhD, Charles Perkins Centre, Sydney Medical School, University of Sydney, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney; D.J. Hunter, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney. Address correspondence to K. Fu, Institute of Bone and Joint Research, Level 10, Kolling Building, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia. E-mail: kafu7690@uni.sydney.edu.au. Accepted for publication March 19, 2019.
Peter A. Cistulli
From the Kolling Institute of Medical Research, Institute of Bone and Joint Research; Department of Rheumatology, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, New South Wales; Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Victoria, Australia; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA; National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney; Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. Supported by NHMRC program grant APP631717. Dr. Hunter is supported by an NHMRC Practitioner Fellowship. Dr. Bennell is supported by an NHMRC Principal Research Fellowship. Mr. Fu received a scholarship from the China Scholarship Council. K. Fu, MBBS, Mch, PhD Candidate, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; J. Makovey, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; B. Metcalf, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; K.L. Bennell, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; Y. Zhang, DSc, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine; R. Asher, PhD, NHMRC Clinical Trials Centre, University of Sydney; S.R. Robbins, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; L.A. Deveza, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; P.A. Cistulli, PhD, Charles Perkins Centre, Sydney Medical School, University of Sydney, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney; D.J. Hunter, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney. Address correspondence to K. Fu, Institute of Bone and Joint Research, Level 10, Kolling Building, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia. E-mail: kafu7690@uni.sydney.edu.au. Accepted for publication March 19, 2019.
David J. Hunter
From the Kolling Institute of Medical Research, Institute of Bone and Joint Research; Department of Rheumatology, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, New South Wales; Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Victoria, Australia; Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA; National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney; Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. Supported by NHMRC program grant APP631717. Dr. Hunter is supported by an NHMRC Practitioner Fellowship. Dr. Bennell is supported by an NHMRC Principal Research Fellowship. Mr. Fu received a scholarship from the China Scholarship Council. K. Fu, MBBS, Mch, PhD Candidate, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; J. Makovey, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; B. Metcalf, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; K.L. Bennell, PhD, Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne; Y. Zhang, DSc, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard School of Medicine; R. Asher, PhD, NHMRC Clinical Trials Centre, University of Sydney; S.R. Robbins, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; L.A. Deveza, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney; P.A. Cistulli, PhD, Charles Perkins Centre, Sydney Medical School, University of Sydney, and Department of Respiratory and Sleep Medicine, Royal North Shore Hospital and Northern Clinical School, University of Sydney; D.J. Hunter, PhD, Kolling Institute of Medical Research, Institute of Bone and Joint Research, University of Sydney, and Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, University of Sydney. Address correspondence to K. Fu, Institute of Bone and Joint Research, Level 10, Kolling Building, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia. E-mail: kafu7690@uni.sydney.edu.au. Accepted for publication March 19, 2019.
Abstract
Objective To evaluate the association of sleep quality, sleep duration, and fatigue with hip pain exacerbations in persons with symptomatic hip osteoarthritis (OA).
Methods Participants (n = 252) were followed for 90 days and asked to complete online questionnaires at 10-day intervals (control periods). A hip pain exacerbation (case periods) was defined as an increase of 2 points in pain intensity compared with baseline on a numeric rating scale (0–10). Subjective sleep quality and sleep duration were assessed using the Pittsburgh Sleep Quality Index, and fatigue was measured by Multidimensional Assessment of Fatigue in both periods. Univariable and multivariable conditional logistic regressions were used to assess the association.
Results Of the 252 participants, 130 (52%) were included in the final analysis. Univariate association analysis showed that both poor sleep quality and greater fatigue were associated with increased odds of pain exacerbations (OR 1.72, 95% CI 1.04–2.86; OR 1.92, 95% CI 1.21–3.05, respectively). Short sleep duration was not associated with pain exacerbations. Poor sleep quality and greater fatigue remained associated with pain exacerbations after adjustment for physical activity and night pain levels in multivariable analysis. There was no significant interaction between sleep quality and fatigue (p = 0.21).
Conclusion Poor sleep quality and greater fatigue were related to pain exacerbation in persons with symptomatic hip OA. Sleep disorders and fatigue should be considered when dealing with pain exacerbations.
In this issue
The Journal of Rheumatology
Vol. 50, Issue 1
1 Jan 2023
Sleep Quality and Fatigue Are Associated with Pain Exacerbations of Hip Osteoarthritis: An Internet-based Case-crossover Study
Kai Fu, Joanna Makovey, Ben Metcalf, Kim L. Bennell, Yuqing Zhang, Rebecca Asher, Sarah R. Robbins, Leticia A. Deveza, Peter A. Cistulli, David J. Hunter
The Journal of Rheumatology Apr 2019, jrheum.181406; DOI: 10.3899/jrheum.181406
Sleep Quality and Fatigue Are Associated with Pain Exacerbations of Hip Osteoarthritis: An Internet-based Case-crossover Study
Kai Fu, Joanna Makovey, Ben Metcalf, Kim L. Bennell, Yuqing Zhang, Rebecca Asher, Sarah R. Robbins, Leticia A. Deveza, Peter A. Cistulli, David J. Hunter
The Journal of Rheumatology Apr 2019, jrheum.181406; DOI: 10.3899/jrheum.181406
