Research ArticleArticle
Assessing Associations of Synovial Perfusion, Cartilage Quality, and Outcome in Rheumatoid Arthritis Using Dynamic Contrast-enhanced Magnetic Resonance Imaging
Philipp Sewerin, Christoph Schleich, Ralph Brinks, Anja Müller-Lutz, Florian Fichter, Markus Eichner, Matthias Schneider, Benedikt Ostendorf and Stefan Vordenbäumen
The Journal of Rheumatology March 2019, jrheum.180832; DOI: https://doi.org/10.3899/jrheum.180832
Philipp Sewerin
From Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, and Department of Diagnostic and Interventional Radiology, Düsseldorf, Germany. This study was supported by a grant from the German “Bundesministerium fur Bildung und Forschung” (BMBF), ArthroMark (01EC1009). P. Sewerin, MD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; C. Schleich, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; R. Brinks, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; A. Müller-Lutz, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; F. Fichter, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Eichner, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Schneider, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; B. Ostendorf, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; S. Vordenbäumen, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology. P. Sewerin and C. Schleich contributed equally to this work. Address correspondence to Dr. P. Sewerin, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, Moorenstrasse 5, 40225 Düsseldorf, Germany. E-mail: philipp.sewerin@med.uni-duesseldorf.de. Accepted for publication February 28, 2019.
Christoph Schleich
From Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, and Department of Diagnostic and Interventional Radiology, Düsseldorf, Germany. This study was supported by a grant from the German “Bundesministerium fur Bildung und Forschung” (BMBF), ArthroMark (01EC1009). P. Sewerin, MD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; C. Schleich, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; R. Brinks, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; A. Müller-Lutz, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; F. Fichter, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Eichner, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Schneider, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; B. Ostendorf, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; S. Vordenbäumen, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology. P. Sewerin and C. Schleich contributed equally to this work. Address correspondence to Dr. P. Sewerin, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, Moorenstrasse 5, 40225 Düsseldorf, Germany. E-mail: philipp.sewerin@med.uni-duesseldorf.de. Accepted for publication February 28, 2019.
Ralph Brinks
From Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, and Department of Diagnostic and Interventional Radiology, Düsseldorf, Germany. This study was supported by a grant from the German “Bundesministerium fur Bildung und Forschung” (BMBF), ArthroMark (01EC1009). P. Sewerin, MD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; C. Schleich, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; R. Brinks, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; A. Müller-Lutz, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; F. Fichter, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Eichner, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Schneider, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; B. Ostendorf, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; S. Vordenbäumen, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology. P. Sewerin and C. Schleich contributed equally to this work. Address correspondence to Dr. P. Sewerin, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, Moorenstrasse 5, 40225 Düsseldorf, Germany. E-mail: philipp.sewerin@med.uni-duesseldorf.de. Accepted for publication February 28, 2019.
Anja Müller-Lutz
From Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, and Department of Diagnostic and Interventional Radiology, Düsseldorf, Germany. This study was supported by a grant from the German “Bundesministerium fur Bildung und Forschung” (BMBF), ArthroMark (01EC1009). P. Sewerin, MD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; C. Schleich, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; R. Brinks, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; A. Müller-Lutz, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; F. Fichter, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Eichner, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Schneider, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; B. Ostendorf, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; S. Vordenbäumen, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology. P. Sewerin and C. Schleich contributed equally to this work. Address correspondence to Dr. P. Sewerin, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, Moorenstrasse 5, 40225 Düsseldorf, Germany. E-mail: philipp.sewerin@med.uni-duesseldorf.de. Accepted for publication February 28, 2019.
Florian Fichter
From Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, and Department of Diagnostic and Interventional Radiology, Düsseldorf, Germany. This study was supported by a grant from the German “Bundesministerium fur Bildung und Forschung” (BMBF), ArthroMark (01EC1009). P. Sewerin, MD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; C. Schleich, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; R. Brinks, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; A. Müller-Lutz, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; F. Fichter, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Eichner, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Schneider, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; B. Ostendorf, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; S. Vordenbäumen, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology. P. Sewerin and C. Schleich contributed equally to this work. Address correspondence to Dr. P. Sewerin, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, Moorenstrasse 5, 40225 Düsseldorf, Germany. E-mail: philipp.sewerin@med.uni-duesseldorf.de. Accepted for publication February 28, 2019.
Markus Eichner
From Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, and Department of Diagnostic and Interventional Radiology, Düsseldorf, Germany. This study was supported by a grant from the German “Bundesministerium fur Bildung und Forschung” (BMBF), ArthroMark (01EC1009). P. Sewerin, MD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; C. Schleich, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; R. Brinks, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; A. Müller-Lutz, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; F. Fichter, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Eichner, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Schneider, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; B. Ostendorf, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; S. Vordenbäumen, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology. P. Sewerin and C. Schleich contributed equally to this work. Address correspondence to Dr. P. Sewerin, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, Moorenstrasse 5, 40225 Düsseldorf, Germany. E-mail: philipp.sewerin@med.uni-duesseldorf.de. Accepted for publication February 28, 2019.
Matthias Schneider
From Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, and Department of Diagnostic and Interventional Radiology, Düsseldorf, Germany. This study was supported by a grant from the German “Bundesministerium fur Bildung und Forschung” (BMBF), ArthroMark (01EC1009). P. Sewerin, MD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; C. Schleich, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; R. Brinks, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; A. Müller-Lutz, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; F. Fichter, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Eichner, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Schneider, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; B. Ostendorf, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; S. Vordenbäumen, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology. P. Sewerin and C. Schleich contributed equally to this work. Address correspondence to Dr. P. Sewerin, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, Moorenstrasse 5, 40225 Düsseldorf, Germany. E-mail: philipp.sewerin@med.uni-duesseldorf.de. Accepted for publication February 28, 2019.
Benedikt Ostendorf
From Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, and Department of Diagnostic and Interventional Radiology, Düsseldorf, Germany. This study was supported by a grant from the German “Bundesministerium fur Bildung und Forschung” (BMBF), ArthroMark (01EC1009). P. Sewerin, MD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; C. Schleich, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; R. Brinks, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; A. Müller-Lutz, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; F. Fichter, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Eichner, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Schneider, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; B. Ostendorf, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; S. Vordenbäumen, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology. P. Sewerin and C. Schleich contributed equally to this work. Address correspondence to Dr. P. Sewerin, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, Moorenstrasse 5, 40225 Düsseldorf, Germany. E-mail: philipp.sewerin@med.uni-duesseldorf.de. Accepted for publication February 28, 2019.
Stefan Vordenbäumen
From Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, and Department of Diagnostic and Interventional Radiology, Düsseldorf, Germany. This study was supported by a grant from the German “Bundesministerium fur Bildung und Forschung” (BMBF), ArthroMark (01EC1009). P. Sewerin, MD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; C. Schleich, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; R. Brinks, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; A. Müller-Lutz, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; F. Fichter, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Eichner, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology; M. Schneider, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; B. Ostendorf, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology; S. Vordenbäumen, MD, PhD, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology. P. Sewerin and C. Schleich contributed equally to this work. Address correspondence to Dr. P. Sewerin, Heinrich-Heine-University Düsseldorf, Medical Faculty, Department and Hiller-Research-Unit for Rheumatology, Moorenstrasse 5, 40225 Düsseldorf, Germany. E-mail: philipp.sewerin@med.uni-duesseldorf.de. Accepted for publication February 28, 2019.
Abstract
Objective To assess associations of synovial perfusion, cartilage quality, and outcome in rheumatoid arthritis (RA).
Methods Synovial perfusion and cartilage quality were assessed by dynamic contrast-enhanced magnetic resonance imaging in metacarpophalangeal joints of 28 treatment-naive patients with RA at baseline and at 3 and 6 months after methotrexate. Analysis was by linear mixed modeling.
Results Synovial perfusion variables were associated with remission (p < 0.05) and cartilage quality (p < 0.004). Maximum synovial enhancement was associated to European League Against Rheumatism response (p < 0.05). Synovial perfusion improved in nonresponders over time (p < 0.05).
Conclusion Synovial perfusion relates to remission, response, and cartilage quality in a cohort of therapy-naive patients with early RA.
In this issue
The Journal of Rheumatology
Vol. 48, Issue 3
1 Mar 2021
Assessing Associations of Synovial Perfusion, Cartilage Quality, and Outcome in Rheumatoid Arthritis Using Dynamic Contrast-enhanced Magnetic Resonance Imaging
Philipp Sewerin, Christoph Schleich, Ralph Brinks, Anja Müller-Lutz, Florian Fichter, Markus Eichner, Matthias Schneider, Benedikt Ostendorf, Stefan Vordenbäumen
The Journal of Rheumatology Mar 2019, jrheum.180832; DOI: 10.3899/jrheum.180832
Assessing Associations of Synovial Perfusion, Cartilage Quality, and Outcome in Rheumatoid Arthritis Using Dynamic Contrast-enhanced Magnetic Resonance Imaging
Philipp Sewerin, Christoph Schleich, Ralph Brinks, Anja Müller-Lutz, Florian Fichter, Markus Eichner, Matthias Schneider, Benedikt Ostendorf, Stefan Vordenbäumen
The Journal of Rheumatology Mar 2019, jrheum.180832; DOI: 10.3899/jrheum.180832
