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The Journal of Rheumatology

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Research ArticleAccepted Article

Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms

Sarah R. Tritsch, Liliana Encinales, Nelly Pacheco, Andres Cadena, Carlos Cure, Elizabeth McMahon, Hugh Watson, Alexandra Porras Ramirez, Alejandro Rico Mendoza, Guangzhao Li, Kunal Khurana, Juan Jose Jaller-Radd, Stella Mejia Castillo, Onaldo Barrios Taborda, Alejandro Jaller Char, Juan Jose Jaller-Char, Lil Avendaño Echavez, Dennys Jiménez, Andres Gonzalez Coba, Magda Alarcon Gomez, Dores Ariza Orozco, Eyda Bravo, Victor Martinez, Brenda Guerra, Gary Simon, Gary S. Firestein and Aileen Y. Chang
The Journal of Rheumatology July 2019, jrheum.190162; DOI: https://doi.org/10.3899/jrheum.190162
Sarah R. Tritsch
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Liliana Encinales
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Nelly Pacheco
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Andres Cadena
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Carlos Cure
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Elizabeth McMahon
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Hugh Watson
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Alexandra Porras Ramirez
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Alejandro Rico Mendoza
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Guangzhao Li
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Kunal Khurana
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Juan Jose Jaller-Radd
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Stella Mejia Castillo
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Onaldo Barrios Taborda
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Alejandro Jaller Char
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Juan Jose Jaller-Char
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Lil Avendaño Echavez
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Dennys Jiménez
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Andres Gonzalez Coba
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Magda Alarcon Gomez
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Dores Ariza Orozco
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Eyda Bravo
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Victor Martinez
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Brenda Guerra
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Gary Simon
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Gary S. Firestein
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Aileen Y. Chang
The George Washington University, Washington, DC, USA; Allied Research Society, LLC, Barranquilla, Atlántico, Colombia; Clinica de La Costa Ltda., Barranquilla, Atlántico, Colombia; Biomelab, Barranquilla, Atlántico, Colombia; Evotec ID, Lyon, France; Universidad El Bosque, Bogotá, Colombia; George Mason University, Washington, DC, USA; Centro de Reumatología y Ortopedia, Barranquilla, Atlántico, Colombia; Universidad Simón Bolívar, Barranquilla, Atlántico, Colombia; University of California, San Diego, San Diego, CA, USA. Grants/Financial Support: The views expressed herein are solely the responsibility of the authors and do not necessarily represent the official views of the Rheumatology Research Foundation or the NIH. Supported by a Pilot award from the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR- 001877). Address correspondence to Aileen Y. Chang, MD, MSPH, The George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue, Suite 5-416, Washington, DC 20037. Email: chang@email.gwu.edu.
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Abstract

Objective To determine the frequency of chronic joint pain and stiffness 3 years after infection with chikungunya virus in a Latin American cohort.

Methods A cross-sectional follow-up of 120 patients from an initial cohort of 500 patients who reported joint pain 2 years after infection from the Atlántico Department, Colombia. Patients were clinically diagnosed as having chikungunya virus during the 2014–2015 epidemic, and baseline and follow-up symptoms at 40 months were evaluated in serologically confirmed cases.

Results Of the initial 500 patients enrolled in the study, 482 had serologically confirmed chikungunya infection. From this group, 123 patients reported joint pain 20 months after infection, and 54% of those patients reported continued joint pain 40 months after infection. Therefore, 1 out of every 8 people who tested serologically positive for chikungunya infection had persistent joint pain 3 years after infection. Participants that followed up in-person were predominantly adult (mean ± SD age 51 ± 14 years) and female (86%). The most common type of pain reported in these patients at 40 months post-infection was pain with periods of relief and subsequent reoccurrence, and over 75% reported stiffness after immobility, with 39% experiencing morning stiffness.

Conclusion This is the first report to describe persistent joint pain and stiffness 40 months after viral infection. The high frequency of chronic disease highlights the need to develop prevention and treatment methods. Further studies should be conducted to understand the similarities between post-chikungunya joint pain and rheumatoid arthritis.

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The Journal of Rheumatology
Vol. 50, Issue 12
1 Dec 2023
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Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms
Sarah R. Tritsch, Liliana Encinales, Nelly Pacheco, Andres Cadena, Carlos Cure, Elizabeth McMahon, Hugh Watson, Alexandra Porras Ramirez, Alejandro Rico Mendoza, Guangzhao Li, Kunal Khurana, Juan Jose Jaller-Radd, Stella Mejia Castillo, Onaldo Barrios Taborda, Alejandro Jaller Char, Juan Jose Jaller-Char, Lil Avendaño Echavez, Dennys Jiménez, Andres Gonzalez Coba, Magda Alarcon Gomez, Dores Ariza Orozco, Eyda Bravo, Victor Martinez, Brenda Guerra, Gary Simon, Gary S. Firestein, Aileen Y. Chang
The Journal of Rheumatology Jul 2019, jrheum.190162; DOI: 10.3899/jrheum.190162

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Accepted manuscript
Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms
Sarah R. Tritsch, Liliana Encinales, Nelly Pacheco, Andres Cadena, Carlos Cure, Elizabeth McMahon, Hugh Watson, Alexandra Porras Ramirez, Alejandro Rico Mendoza, Guangzhao Li, Kunal Khurana, Juan Jose Jaller-Radd, Stella Mejia Castillo, Onaldo Barrios Taborda, Alejandro Jaller Char, Juan Jose Jaller-Char, Lil Avendaño Echavez, Dennys Jiménez, Andres Gonzalez Coba, Magda Alarcon Gomez, Dores Ariza Orozco, Eyda Bravo, Victor Martinez, Brenda Guerra, Gary Simon, Gary S. Firestein, Aileen Y. Chang
The Journal of Rheumatology Jul 2019, jrheum.190162; DOI: 10.3899/jrheum.190162
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