Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on YouTube
  • Follow jrheum on Instagram
  • Follow jrheum on RSS
Research ArticleAccepted Article

Impact of gut involvement in patients with high probability of early spondyloarthritis. Data from DESIR cohort.

Daniel Wendling, Xavier Guillot, Clément Prati, Corinne Miceli-Richard, Anna Molto, Rik Lories and Maxime Dougados
The Journal of Rheumatology June 2019, jrheum.181326; DOI: https://doi.org/10.3899/jrheum.181326
Daniel Wendling
From the Rheumatology, CHRU de Besançon (University Teaching Hospital), Boulevard Fleming, 25030 Besançon, France; Université Bourgogne Franche-Comté, EA4266 (Pathogens and Inflammation, EPILAB), Besançon, France; Université Bourgogne Franche-Comté, EA4267 (PEPITE), FHU INCREASE, Besançon, France; Paris Descartes University, Department of Rheumatology, Hôpital Cochin, AP-HP, EULAR center of excellence, Paris , France; INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, Paris 14, France; Division of Rheumatology, Department of Development and Regeneration, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xavier Guillot
From the Rheumatology, CHRU de Besançon (University Teaching Hospital), Boulevard Fleming, 25030 Besançon, France; Université Bourgogne Franche-Comté, EA4266 (Pathogens and Inflammation, EPILAB), Besançon, France; Université Bourgogne Franche-Comté, EA4267 (PEPITE), FHU INCREASE, Besançon, France; Paris Descartes University, Department of Rheumatology, Hôpital Cochin, AP-HP, EULAR center of excellence, Paris , France; INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, Paris 14, France; Division of Rheumatology, Department of Development and Regeneration, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Clément Prati
From the Rheumatology, CHRU de Besançon (University Teaching Hospital), Boulevard Fleming, 25030 Besançon, France; Université Bourgogne Franche-Comté, EA4266 (Pathogens and Inflammation, EPILAB), Besançon, France; Université Bourgogne Franche-Comté, EA4267 (PEPITE), FHU INCREASE, Besançon, France; Paris Descartes University, Department of Rheumatology, Hôpital Cochin, AP-HP, EULAR center of excellence, Paris , France; INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, Paris 14, France; Division of Rheumatology, Department of Development and Regeneration, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Corinne Miceli-Richard
From the Rheumatology, CHRU de Besançon (University Teaching Hospital), Boulevard Fleming, 25030 Besançon, France; Université Bourgogne Franche-Comté, EA4266 (Pathogens and Inflammation, EPILAB), Besançon, France; Université Bourgogne Franche-Comté, EA4267 (PEPITE), FHU INCREASE, Besançon, France; Paris Descartes University, Department of Rheumatology, Hôpital Cochin, AP-HP, EULAR center of excellence, Paris , France; INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, Paris 14, France; Division of Rheumatology, Department of Development and Regeneration, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anna Molto
From the Rheumatology, CHRU de Besançon (University Teaching Hospital), Boulevard Fleming, 25030 Besançon, France; Université Bourgogne Franche-Comté, EA4266 (Pathogens and Inflammation, EPILAB), Besançon, France; Université Bourgogne Franche-Comté, EA4267 (PEPITE), FHU INCREASE, Besançon, France; Paris Descartes University, Department of Rheumatology, Hôpital Cochin, AP-HP, EULAR center of excellence, Paris , France; INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, Paris 14, France; Division of Rheumatology, Department of Development and Regeneration, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rik Lories
From the Rheumatology, CHRU de Besançon (University Teaching Hospital), Boulevard Fleming, 25030 Besançon, France; Université Bourgogne Franche-Comté, EA4266 (Pathogens and Inflammation, EPILAB), Besançon, France; Université Bourgogne Franche-Comté, EA4267 (PEPITE), FHU INCREASE, Besançon, France; Paris Descartes University, Department of Rheumatology, Hôpital Cochin, AP-HP, EULAR center of excellence, Paris , France; INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, Paris 14, France; Division of Rheumatology, Department of Development and Regeneration, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maxime Dougados
From the Rheumatology, CHRU de Besançon (University Teaching Hospital), Boulevard Fleming, 25030 Besançon, France; Université Bourgogne Franche-Comté, EA4266 (Pathogens and Inflammation, EPILAB), Besançon, France; Université Bourgogne Franche-Comté, EA4267 (PEPITE), FHU INCREASE, Besançon, France; Paris Descartes University, Department of Rheumatology, Hôpital Cochin, AP-HP, EULAR center of excellence, Paris , France; INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, Paris 14, France; Division of Rheumatology, Department of Development and Regeneration, University Hospital Leuven, KU Leuven, Leuven, Belgium.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • References
  • PDF
  • eLetters
Next
Loading

Abstract

Objective Inflammatory bowel disease (IBD) is a well-known extra articular feature of spondyloarthritis (SpA).The aims of this study were to evaluate in DESIR cohort factors associated with IBD and incidence over 5 years follow-up.

Methods DESIR is a prospective observational cohort of patients with recent onset inflammatory back pain suggestive of axial SpA. All available variables in the database were compared between patients with and without IBD at baseline and 5 years, and occurrence over 5 years of follow-up, with uni and then multivariable analysis.

Results At baseline, 708 patients, 35 had IBD : prevalence 4.94% [CI 95% : 3.3 – 6.5]. IBD was associated (multivariable) with history of uveitis, levels of DKK-1 and TNF, but not with phenotypic presentation (peripheral arthritis, enthesitis, dactylitis, uveitis) or baseline serum levels of other cytokines. At 5 years, 480 patients were analyzed, 58 with IBD. IBD was associated (multivariable) with fulfillment of modified New York criteria, sick leave, BASDAI, and smoking. No association with MRI scores, enthesitis, psoriasis, BMD. 23 incident cases of IBD were recorded: estimated occurrence rate of 0.95/100 [0.57 – 1.35] patient-years. Incidence of IBD is associated (multivariable) with : HLA B27 : OR 0.36 [0.22 – 0.59], fulfillment of modified New York criteria: OR 3.35 [1.85 – 6.08], familial history of IBD : OR 3.31[1.62 – 6.77] .

Conclusion in early SpA, IBD occurs with an incidence of 1/100 patient-years, and is associated with poor outcome, familial history of IBD, absence of HLA-B27, fulfillment of modified New York criteria.

Next
Back to top

In this issue

The Journal of Rheumatology
Vol. 50, Issue 2
1 Feb 2023
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Impact of gut involvement in patients with high probability of early spondyloarthritis. Data from DESIR cohort.
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Accepted manuscript
Impact of gut involvement in patients with high probability of early spondyloarthritis. Data from DESIR cohort.
Daniel Wendling, Xavier Guillot, Clément Prati, Corinne Miceli-Richard, Anna Molto, Rik Lories, Maxime Dougados
The Journal of Rheumatology Jun 2019, jrheum.181326; DOI: 10.3899/jrheum.181326

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
Accepted manuscript
Impact of gut involvement in patients with high probability of early spondyloarthritis. Data from DESIR cohort.
Daniel Wendling, Xavier Guillot, Clément Prati, Corinne Miceli-Richard, Anna Molto, Rik Lories, Maxime Dougados
The Journal of Rheumatology Jun 2019, jrheum.181326; DOI: 10.3899/jrheum.181326
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics
  • References
  • PDF
  • eLetters

Related Articles

Cited By...

More in this TOC Section

  • Pediatric Sarcoidosis: Retrospective Analysis of Biopsy-proven Patients
Show more Accepted Article

Similar Articles

Content

  • First Release
  • Current
  • Archives
  • Collections
  • Audiovisual Rheum
  • COVID-19 and Rheumatology

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • Privacy/GDPR Policy
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2022 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire