Research ArticleAccepted Article
Anti-CCP3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis
Heather M. Berens, Kristen J. Polinski, Ted R. Mikuls, Sonia Khatter, Justin August, Ashley Visser, Michael Mahler, Michael Weisman, James R. O’Dell, Richard M. Keating, Jane H. Buckner, Peter K. Gregersen, Jill M. Norris, V. Michael Holers, Kevin D. Deane and M. Kristen Demoruelle
The Journal of Rheumatology April 2019, jrheum.180897; DOI: https://doi.org/10.3899/jrheum.180897
Heather M. Berens
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
Kristen J. Polinski
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
Ted R. Mikuls
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
Sonia Khatter
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
Justin August
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
Ashley Visser
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
Michael Mahler
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
Michael Weisman
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
James R. O’Dell
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
Richard M. Keating
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
Jane H. Buckner
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
Peter K. Gregersen
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
Jill M. Norris
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
V. Michael Holers
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
Kevin D. Deane
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
M. Kristen Demoruelle
From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Division of Rheumatology, Veteran Affairs Nebraska Western Iowa Health Care System, Omaha, NE, USA; Department of Research, INOVA Diagnostics, San Diego, CA, USA; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Rheumatology, Scripps Green Hospital, La Jolla, CA, USA; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, USA. This work was supported by the National Institutes of Health [grant numbers AR066712, AI110503, AI101981, and T32AR007534], and a Rheumatology Research Foundation Resident Research Preceptorship Award. Contents are the authors’ sole responsibility and do not necessarily represent official NIH views. Address correspondence to M. Kristen Demoruelle, MD, PhD University of Colorado Denver School of Medicine Division of Rheumatology 1775 Aurora Court, Mail Stop B-115 Aurora, CO 80045 Email: Kristen.Demoruelle@UCDenver.edu
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Accepted manuscript
Anti-CCP3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis
Heather M. Berens, Kristen J. Polinski, Ted R. Mikuls, Sonia Khatter, Justin August, Ashley Visser, Michael Mahler, Michael Weisman, James R. O’Dell, Richard M. Keating, Jane H. Buckner, Peter K. Gregersen, Jill M. Norris, V. Michael Holers, Kevin D. Deane, M. Kristen Demoruelle
The Journal of Rheumatology Apr 2019, jrheum.180897; DOI: 10.3899/jrheum.180897
Accepted manuscript
Anti-CCP3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis
Heather M. Berens, Kristen J. Polinski, Ted R. Mikuls, Sonia Khatter, Justin August, Ashley Visser, Michael Mahler, Michael Weisman, James R. O’Dell, Richard M. Keating, Jane H. Buckner, Peter K. Gregersen, Jill M. Norris, V. Michael Holers, Kevin D. Deane, M. Kristen Demoruelle
The Journal of Rheumatology Apr 2019, jrheum.180897; DOI: 10.3899/jrheum.180897