Research ArticleAccepted Article
Neutropenia During Tocilizumab Treatment Is Not Associated With Infection Risk in Systemic or Polyarticular-Course Juvenile Idiopathic Arthritis
Manuela Pardeo, Jianmei Wang, Nicolino Ruperto, Ekaterina Alexeeva, Vyacheslav Chasnyk, Rayfel Schneider, Gerd Horneff, Hans-Iko Huppertz, Kirsten Minden, Karen Onel, Lawrence Zemel, Alan Martin, Isabelle Koné-Paut, Antigoni Siamopoulou-Mavridou, Clovis A. Silva, Benjamin Porter-Brown, Kamal N. Bharucha, Hermine I. Brunner and Fabrizio De Benedetti for the Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)
The Journal of Rheumatology March 2019, jrheum.180795; DOI: https://doi.org/10.3899/jrheum.180795
Manuela Pardeo
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Jianmei Wang
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Nicolino Ruperto
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Ekaterina Alexeeva
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Vyacheslav Chasnyk
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Rayfel Schneider
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Gerd Horneff
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Hans-Iko Huppertz
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Kirsten Minden
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Karen Onel
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Lawrence Zemel
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Alan Martin
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Isabelle Koné-Paut
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Antigoni Siamopoulou-Mavridou
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Clovis A. Silva
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Benjamin Porter-Brown
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Kamal N. Bharucha
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Hermine I. Brunner
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Fabrizio De Benedetti
IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, United Kingdom; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution “National Medical Research Center of Children's Health” of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, Saint-Petersburg, Russian Federation; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, ON, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne, Germany; Prof Hess Children's Hospital and Pediatric Intensive Care Medicine, Bremen, Germany; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone & Joint Associates, Tulsa, Oklahoma; National Referral Centre of Auto- Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, APHP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Pediatric Rheumatology Unit, Sao Paulo, Brazil; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio. The study was sponsored by F. Hoffmann La Roche Ltd. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann La- Roche Ltd. Address correspondence to Fabrizio De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net
Data supplements
Data Supplement
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Accepted manuscript
Neutropenia During Tocilizumab Treatment Is Not Associated With Infection Risk in Systemic or Polyarticular-Course Juvenile Idiopathic Arthritis
Manuela Pardeo, Jianmei Wang, Nicolino Ruperto, Ekaterina Alexeeva, Vyacheslav Chasnyk, Rayfel Schneider, Gerd Horneff, Hans-Iko Huppertz, Kirsten Minden, Karen Onel, Lawrence Zemel, Alan Martin, Isabelle Koné-Paut, Antigoni Siamopoulou-Mavridou, Clovis A. Silva, Benjamin Porter-Brown, Kamal N. Bharucha, Hermine I. Brunner, Fabrizio De Benedetti
The Journal of Rheumatology Mar 2019, jrheum.180795; DOI: 10.3899/jrheum.180795
Accepted manuscript
Neutropenia During Tocilizumab Treatment Is Not Associated With Infection Risk in Systemic or Polyarticular-Course Juvenile Idiopathic Arthritis
Manuela Pardeo, Jianmei Wang, Nicolino Ruperto, Ekaterina Alexeeva, Vyacheslav Chasnyk, Rayfel Schneider, Gerd Horneff, Hans-Iko Huppertz, Kirsten Minden, Karen Onel, Lawrence Zemel, Alan Martin, Isabelle Koné-Paut, Antigoni Siamopoulou-Mavridou, Clovis A. Silva, Benjamin Porter-Brown, Kamal N. Bharucha, Hermine I. Brunner, Fabrizio De Benedetti
The Journal of Rheumatology Mar 2019, jrheum.180795; DOI: 10.3899/jrheum.180795