Research ArticleArticle
The SPECTRA Collaboration OMERACT Working Group: Criterion Validity of Joint Space Outcomes with High Resolution Peripheral Quantitative Computed Tomography
Sarah L. Manske, Scott C. Brunet, Stephanie Finzel, Kathryn S. Stok, Philip G. Conaghan, Steven K. Boyd and Cheryl Barnabe
The Journal of Rheumatology January 2019, jrheum.180870; DOI: https://doi.org/10.3899/jrheum.180870
Sarah L. Manske
From the Department of Radiology, and Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary; Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Biomedical Engineering, The University of Melbourne, Parkville, Australia; Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK. The study was funded by The Arthritis Society. PGC is supported in part by the UK NIHR Leeds Biomedical Research Centre. S.L. Manske, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S.C. Brunet, BSc, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S. Finzel, MD, Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg; K.S. Stok, PhD, Department of Biomedical Engineering, The University of Melbourne; P.G. Conaghan, MD, PhD, Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; S.K. Boyd, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; C. Barnabe, MSc, MD, Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary. Address correspondence to Dr. S.L. Manske, 3280 Hospital Dr NW, Calgary, Alberta T2N 4Z6, Canada. E-mail: smanske@ucalgary.ca. Accepted for publication November 14, 2018.
Scott C. Brunet
From the Department of Radiology, and Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary; Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Biomedical Engineering, The University of Melbourne, Parkville, Australia; Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK. The study was funded by The Arthritis Society. PGC is supported in part by the UK NIHR Leeds Biomedical Research Centre. S.L. Manske, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S.C. Brunet, BSc, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S. Finzel, MD, Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg; K.S. Stok, PhD, Department of Biomedical Engineering, The University of Melbourne; P.G. Conaghan, MD, PhD, Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; S.K. Boyd, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; C. Barnabe, MSc, MD, Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary. Address correspondence to Dr. S.L. Manske, 3280 Hospital Dr NW, Calgary, Alberta T2N 4Z6, Canada. E-mail: smanske@ucalgary.ca. Accepted for publication November 14, 2018.
Stephanie Finzel
From the Department of Radiology, and Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary; Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Biomedical Engineering, The University of Melbourne, Parkville, Australia; Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK. The study was funded by The Arthritis Society. PGC is supported in part by the UK NIHR Leeds Biomedical Research Centre. S.L. Manske, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S.C. Brunet, BSc, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S. Finzel, MD, Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg; K.S. Stok, PhD, Department of Biomedical Engineering, The University of Melbourne; P.G. Conaghan, MD, PhD, Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; S.K. Boyd, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; C. Barnabe, MSc, MD, Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary. Address correspondence to Dr. S.L. Manske, 3280 Hospital Dr NW, Calgary, Alberta T2N 4Z6, Canada. E-mail: smanske@ucalgary.ca. Accepted for publication November 14, 2018.
Kathryn S. Stok
From the Department of Radiology, and Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary; Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Biomedical Engineering, The University of Melbourne, Parkville, Australia; Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK. The study was funded by The Arthritis Society. PGC is supported in part by the UK NIHR Leeds Biomedical Research Centre. S.L. Manske, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S.C. Brunet, BSc, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S. Finzel, MD, Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg; K.S. Stok, PhD, Department of Biomedical Engineering, The University of Melbourne; P.G. Conaghan, MD, PhD, Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; S.K. Boyd, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; C. Barnabe, MSc, MD, Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary. Address correspondence to Dr. S.L. Manske, 3280 Hospital Dr NW, Calgary, Alberta T2N 4Z6, Canada. E-mail: smanske@ucalgary.ca. Accepted for publication November 14, 2018.
Philip G. Conaghan
From the Department of Radiology, and Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary; Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Biomedical Engineering, The University of Melbourne, Parkville, Australia; Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK. The study was funded by The Arthritis Society. PGC is supported in part by the UK NIHR Leeds Biomedical Research Centre. S.L. Manske, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S.C. Brunet, BSc, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S. Finzel, MD, Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg; K.S. Stok, PhD, Department of Biomedical Engineering, The University of Melbourne; P.G. Conaghan, MD, PhD, Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; S.K. Boyd, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; C. Barnabe, MSc, MD, Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary. Address correspondence to Dr. S.L. Manske, 3280 Hospital Dr NW, Calgary, Alberta T2N 4Z6, Canada. E-mail: smanske@ucalgary.ca. Accepted for publication November 14, 2018.
Steven K. Boyd
From the Department of Radiology, and Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary; Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Biomedical Engineering, The University of Melbourne, Parkville, Australia; Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK. The study was funded by The Arthritis Society. PGC is supported in part by the UK NIHR Leeds Biomedical Research Centre. S.L. Manske, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S.C. Brunet, BSc, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S. Finzel, MD, Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg; K.S. Stok, PhD, Department of Biomedical Engineering, The University of Melbourne; P.G. Conaghan, MD, PhD, Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; S.K. Boyd, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; C. Barnabe, MSc, MD, Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary. Address correspondence to Dr. S.L. Manske, 3280 Hospital Dr NW, Calgary, Alberta T2N 4Z6, Canada. E-mail: smanske@ucalgary.ca. Accepted for publication November 14, 2018.
Cheryl Barnabe
From the Department of Radiology, and Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary; Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Biomedical Engineering, The University of Melbourne, Parkville, Australia; Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK. The study was funded by The Arthritis Society. PGC is supported in part by the UK NIHR Leeds Biomedical Research Centre. S.L. Manske, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S.C. Brunet, BSc, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; S. Finzel, MD, Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg; K.S. Stok, PhD, Department of Biomedical Engineering, The University of Melbourne; P.G. Conaghan, MD, PhD, Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; S.K. Boyd, PhD, Department of Radiology, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, and Biomedical Engineering Graduate Program, Department of Radiology, Cumming School of Medicine, University of Calgary; C. Barnabe, MSc, MD, Department of Medicine, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary. Address correspondence to Dr. S.L. Manske, 3280 Hospital Dr NW, Calgary, Alberta T2N 4Z6, Canada. E-mail: smanske@ucalgary.ca. Accepted for publication November 14, 2018.
Abstract
Objective We assessed construct validity of high-resolution peripheral quantitative computed tomography (HR-pQCT) joint space outcomes by comparison with radiographs in patients with rheumatoid arthritis.
Methods In 43 patients, quantitative, volumetric, HR-pQCT measurements were compared with ordinal Sharp/van der Heijde scoring (SvdH) in the 2nd and 3rd metacarpophalangeal joints.
Results Generalized estimating equations showed that joint space minimum, SD, and asymmetry by HR-pQCT were associated with SvdH scores (p < 0.05). There was a considerable range in HR-pQCT measurements at SvdH equal to 0.
Conclusion HR-pQCT demonstrated construct validity outcomes and provides improved 3-D visualization of joint space.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
The SPECTRA Collaboration OMERACT Working Group: Criterion Validity of Joint Space Outcomes with High Resolution Peripheral Quantitative Computed Tomography
Sarah L. Manske, Scott C. Brunet, Stephanie Finzel, Kathryn S. Stok, Philip G. Conaghan, Steven K. Boyd, Cheryl Barnabe
The Journal of Rheumatology Jan 2019, jrheum.180870; DOI: 10.3899/jrheum.180870
The SPECTRA Collaboration OMERACT Working Group: Criterion Validity of Joint Space Outcomes with High Resolution Peripheral Quantitative Computed Tomography
Sarah L. Manske, Scott C. Brunet, Stephanie Finzel, Kathryn S. Stok, Philip G. Conaghan, Steven K. Boyd, Cheryl Barnabe
The Journal of Rheumatology Jan 2019, jrheum.180870; DOI: 10.3899/jrheum.180870