Does Rheumatoid Arthritis Really Improve During Pregnancy? A Systematic Review and Metaanalysis

From the Rheumatology Department, London North West Healthcare National Health Service (NHS) Trust; General Medicine, Croydon University Hospital; Statistics Department, Royal Free Hospital; Centre for Rheumatology Research, Rayne Institute, University College London, London, UK. This work was undertaken at University College London Hospitals, which received a proportion of funding from the UK Department of Health’s National Institute for Health Research Biomedical Research Centres funding scheme. H. Jethwa, Specialist Registrar in Rheumatology, BSc, MBChB, MRCP, Rheumatology Department, London North West Healthcare NHS Trust; S. Lam, General Practitioner Trainee, BSc, MBBS, General Medicine, Croydon University Hospital; C. Smith, Research Statistician, PhD, Statistics Department, Royal Free Hospital; I. Giles, Consultant Rheumatologist, PhD, FRCP, Centre for Rheumatology Research, Rayne Institute, University College London. H. Jethwa and S. Lam contributed equally to this study. Address correspondence to H. Jethwa, Rheumatology Department, Ealing Hospital, Uxbridge Road, Southall UB1 3HW, UK. E-mail: hannahjethwa@nhs.net. Accepted for publication July 24, 2018.

From the Rheumatology Department, London North West Healthcare National Health Service (NHS) Trust; General Medicine, Croydon University Hospital; Statistics Department, Royal Free Hospital; Centre for Rheumatology Research, Rayne Institute, University College London, London, UK. This work was undertaken at University College London Hospitals, which received a proportion of funding from the UK Department of Health’s National Institute for Health Research Biomedical Research Centres funding scheme. H. Jethwa, Specialist Registrar in Rheumatology, BSc, MBChB, MRCP, Rheumatology Department, London North West Healthcare NHS Trust; S. Lam, General Practitioner Trainee, BSc, MBBS, General Medicine, Croydon University Hospital; C. Smith, Research Statistician, PhD, Statistics Department, Royal Free Hospital; I. Giles, Consultant Rheumatologist, PhD, FRCP, Centre for Rheumatology Research, Rayne Institute, University College London. H. Jethwa and S. Lam contributed equally to this study. Address correspondence to H. Jethwa, Rheumatology Department, Ealing Hospital, Uxbridge Road, Southall UB1 3HW, UK. E-mail: hannahjethwa@nhs.net. Accepted for publication July 24, 2018.

From the Rheumatology Department, London North West Healthcare National Health Service (NHS) Trust; General Medicine, Croydon University Hospital; Statistics Department, Royal Free Hospital; Centre for Rheumatology Research, Rayne Institute, University College London, London, UK. This work was undertaken at University College London Hospitals, which received a proportion of funding from the UK Department of Health’s National Institute for Health Research Biomedical Research Centres funding scheme. H. Jethwa, Specialist Registrar in Rheumatology, BSc, MBChB, MRCP, Rheumatology Department, London North West Healthcare NHS Trust; S. Lam, General Practitioner Trainee, BSc, MBBS, General Medicine, Croydon University Hospital; C. Smith, Research Statistician, PhD, Statistics Department, Royal Free Hospital; I. Giles, Consultant Rheumatologist, PhD, FRCP, Centre for Rheumatology Research, Rayne Institute, University College London. H. Jethwa and S. Lam contributed equally to this study. Address correspondence to H. Jethwa, Rheumatology Department, Ealing Hospital, Uxbridge Road, Southall UB1 3HW, UK. E-mail: hannahjethwa@nhs.net. Accepted for publication July 24, 2018.

From the Rheumatology Department, London North West Healthcare National Health Service (NHS) Trust; General Medicine, Croydon University Hospital; Statistics Department, Royal Free Hospital; Centre for Rheumatology Research, Rayne Institute, University College London, London, UK. This work was undertaken at University College London Hospitals, which received a proportion of funding from the UK Department of Health’s National Institute for Health Research Biomedical Research Centres funding scheme. H. Jethwa, Specialist Registrar in Rheumatology, BSc, MBChB, MRCP, Rheumatology Department, London North West Healthcare NHS Trust; S. Lam, General Practitioner Trainee, BSc, MBBS, General Medicine, Croydon University Hospital; C. Smith, Research Statistician, PhD, Statistics Department, Royal Free Hospital; I. Giles, Consultant Rheumatologist, PhD, FRCP, Centre for Rheumatology Research, Rayne Institute, University College London. H. Jethwa and S. Lam contributed equally to this study. Address correspondence to H. Jethwa, Rheumatology Department, Ealing Hospital, Uxbridge Road, Southall UB1 3HW, UK. E-mail: hannahjethwa@nhs.net. Accepted for publication July 24, 2018.