Research ArticleArticle
An International Delphi Survey for the Definition of New Classification Criteria for Familial Mediterranean Fever, Mevalonate Kinase Deficiency, TNF Receptor–associated Periodic Fever Syndromes, and Cryopyrin-associated Periodic Syndrome
Silvia Federici, Federica Vanoni, Eldad Ben-Chetrit, Luca Cantarini, Joost Frenkel, Raphaela Goldbach-Mansky, Ahmet Gul, Hal Hoffman, Isabelle Koné-Paut, Jasmin Kuemmerle-Deschner, Helen J. Lachmann, Alberto Martini, Laura Obici, Seza Ozen, Anna Simon, Michael Hofer, Nicolino Ruperto and Marco Gattorno for Eurofever and the Pediatric Rheumatology International Trials Organization (PRINTO)
The Journal of Rheumatology November 2018, jrheum.180056; DOI: https://doi.org/10.3899/jrheum.180056
Silvia Federici
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Federica Vanoni
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Eldad Ben-Chetrit
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Luca Cantarini
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Joost Frenkel
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Raphaela Goldbach-Mansky
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Ahmet Gul
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Hal Hoffman
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Isabelle Koné-Paut
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Jasmin Kuemmerle-Deschner
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Helen J. Lachmann
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Alberto Martini
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Laura Obici
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Seza Ozen
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Anna Simon
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Michael Hofer
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Nicolino Ruperto
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
Marco Gattorno
From the Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Direzione Scientifica, PRINTO, Genoa, Italy; Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, Bellinzona, Switzerland; Hadassah-Hebrew University Hospital, Rheumatology Unit, Jerusalem, Israel; University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, Siena, Italy; Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie, Utrecht, the Netherlands; Rady Children’s Specialists of San Diego, San Diego, California, USA; İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji, İstanbul, Turkey; Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases, CEREMAI, Centre Hospitalier Universitaire (CHU) de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre, France; Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tuebingen, University Hospital Tübingen, Tübingen, Germany; Royal Free Campus, National Amyloidosis Centre, London, UK; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Pavia, Italy; Hacettepe University, Department of Pediatric Rheumatology, Ankara, Turkey; Radboud University Medical Center (UMC), Pediatric Rheumatology, Nijmegen, the Netherlands; Unité Romande d’Immuno-rhumatologie Pédiatrique, Centre hospitalier universitaire vaudois (CHUV), University of Lausanne, Lausanne; Geneva University Hospitals, Geneva, Switzerland. This study is part of the International Study Group for Systemic Autoinflammatory Diseases project, funded by the E-Rare-3 program, grant number 9003037603. S. Federici, MD, PhD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; F. Vanoni, MD, Ospedale Regionale di Bellinzona e Valli, Dipartimento di Pediatria, and Geneva University Hospitals; E. Ben-Chetrit, MD, Hadassah-Hebrew University Hospital, Rheumatology Unit; L. Cantarini, MD, PhD, University of Siena, Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit; J. Frenkel, MD, PhD, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum Utrecht, Afdeling Kinderreumatologie; R. Goldbach-Mansky, MD, MHS, Rady Children’s Specialists of San Diego; A. Gul, MD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Pediatrik Romatoloji; H. Hoffman, MD, Rady Children’s Specialists of San Diego; I. Koné-Paut, MD, Department of Pediatric Rheumatology, National Referral Centre of Auto-Inflammatory Diseases CEREMAI, CHU de Biĉetre, AP-HP, University of Paris Sud, le Kremlin Biĉetre; J. Kuemmerle-Deschner, MD, Division of Rheumatology, Department of Pediatrics and Autoinflammation Reference Center Tübingen, University Hospital Tübingen; H.J. Lachmann, MD, Royal Free Campus, National Amyloidosis Centre; A. Martini, MD, Istituto Giannina Gaslini, Direzione Scientifica; L. Obici, MD, Fondazione IRCCS Policlinico San Matteo, Centro per lo Studio e la Cura delle Amiloidosi Sistemiche; S. Ozen, MD, Hacettepe University, Department of Pediatric Rheumatology; A. Simon, MD, PhD, Radboud UMC, Pediatric Rheumatology; M. Hofer, MD, Unité Romande d’Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, and Geneva University Hospitals; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; M. Gattorno, MD, Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO. These authors contributed equally to this article: S. Federici, F. Vanoni, N. Ruperto, and M. Gattorno. Address correspondence to Dr. S. Federici, Istituto Giannina Gaslini, Pediatric Division, Via Gaslini 5, Genoa 16147, Italy. E-mail: silviafederici@gmail.com. Accepted for publication July 18, 2018.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
An International Delphi Survey for the Definition of New Classification Criteria for Familial Mediterranean Fever, Mevalonate Kinase Deficiency, TNF Receptor–associated Periodic Fever Syndromes, and Cryopyrin-associated Periodic Syndrome
Silvia Federici, Federica Vanoni, Eldad Ben-Chetrit, Luca Cantarini, Joost Frenkel, Raphaela Goldbach-Mansky, Ahmet Gul, Hal Hoffman, Isabelle Koné-Paut, Jasmin Kuemmerle-Deschner, Helen J. Lachmann, Alberto Martini, Laura Obici, Seza Ozen, Anna Simon, Michael Hofer, Nicolino Ruperto, Marco Gattorno
The Journal of Rheumatology Nov 2018, jrheum.180056; DOI: 10.3899/jrheum.180056
An International Delphi Survey for the Definition of New Classification Criteria for Familial Mediterranean Fever, Mevalonate Kinase Deficiency, TNF Receptor–associated Periodic Fever Syndromes, and Cryopyrin-associated Periodic Syndrome
Silvia Federici, Federica Vanoni, Eldad Ben-Chetrit, Luca Cantarini, Joost Frenkel, Raphaela Goldbach-Mansky, Ahmet Gul, Hal Hoffman, Isabelle Koné-Paut, Jasmin Kuemmerle-Deschner, Helen J. Lachmann, Alberto Martini, Laura Obici, Seza Ozen, Anna Simon, Michael Hofer, Nicolino Ruperto, Marco Gattorno
The Journal of Rheumatology Nov 2018, jrheum.180056; DOI: 10.3899/jrheum.180056