Research ArticleArticle
Quadriceps Weakness and the Risk of Knee Cartilage Loss Seen on Magnetic Resonance Imaging in a Population-based Cohort with Knee Pain
Carson Chin, Eric C. Sayre, Ali Guermazi, Savvas Nicolaou, John M. Esdaile, Jacek Kopec, Anona Thorne, Joel Singer, Hubert Wong and Jolanda Cibere
The Journal of Rheumatology October 2018, jrheum.170875; DOI: https://doi.org/10.3899/jrheum.170875
Carson Chin
From the Department of Medicine, the Division of Rheumatology, the Department of Radiology and the School of Population and Public Health, University of British Columbia, Vancouver; Arthritis Research Canada, Vancouver; Canadian Institutes of Health Research HIV Trials Network, Vancouver; Centre for Health Evaluation and Outcomes Sciences, Vancouver, British Columbia, Canada; Department of Radiology, Boston University Medical Center, Boston, Massachusetts, USA. This research was funded by grants from the Canadian Institutes of Health Research (89890, 89997), the Canadian Arthritis Network (01-MNO-09N), and the Arthritis Society (TAS04/0063). Dr. Cibere’s work was supported by an investigator award from the Arthritis Society (INS-12-027). C. Chin, MD, FRCPC, Division of Rheumatology, University of British Columbia; E.C. Sayre, PhD, Research Associate, Arthritis Research Canada; A. Guermazi, MD, Professor, Department of Radiology, Boston University Medical Center; S. Nicolaou, MD, Assistant Professor, Department of Radiology, University of British Columbia (UBC), Director of Emergency/Trauma Imaging, Vancouver General Hospital; H. Wong, PhD, Associate Professor, School of Population and Public Health, UBC, and Associate Head, Data and Methodology, CIHR Canadian HIV Trials Network; A. Thorne, MSc, Senior Biostatistician, CIHR Canadian HIV Trials Network, School of Population and Public Health, UBC; J. Singer, PhD, Professor, School of Population and Public Health, UBC, and Centre for Health Evaluation and Outcome Sciences; J.A. Kopec, MD, MSc, PhD, Associate Professor, School of Population and Public Health, UBC, and Research Scientist, Arthritis Research Canada; J.M. Esdaile, MD, MPH, Professor, Department of Medicine, UBC, and Scientific Director, Arthritis Research Canada; J. Cibere, MD, PhD, Associate Professor, Department of Medicine, UBC, and Senior Research Scientist, Arthritis Research Canada. Address correspondence to Dr. C. Chin, 802-1200 Burrard St., Vancouver, British Columbia V6Z 2C7, Canada. E-mail: carson.c.chin@gmail.com. Accepted for publication July 18, 2018.
Eric C. Sayre
From the Department of Medicine, the Division of Rheumatology, the Department of Radiology and the School of Population and Public Health, University of British Columbia, Vancouver; Arthritis Research Canada, Vancouver; Canadian Institutes of Health Research HIV Trials Network, Vancouver; Centre for Health Evaluation and Outcomes Sciences, Vancouver, British Columbia, Canada; Department of Radiology, Boston University Medical Center, Boston, Massachusetts, USA. This research was funded by grants from the Canadian Institutes of Health Research (89890, 89997), the Canadian Arthritis Network (01-MNO-09N), and the Arthritis Society (TAS04/0063). Dr. Cibere’s work was supported by an investigator award from the Arthritis Society (INS-12-027). C. Chin, MD, FRCPC, Division of Rheumatology, University of British Columbia; E.C. Sayre, PhD, Research Associate, Arthritis Research Canada; A. Guermazi, MD, Professor, Department of Radiology, Boston University Medical Center; S. Nicolaou, MD, Assistant Professor, Department of Radiology, University of British Columbia (UBC), Director of Emergency/Trauma Imaging, Vancouver General Hospital; H. Wong, PhD, Associate Professor, School of Population and Public Health, UBC, and Associate Head, Data and Methodology, CIHR Canadian HIV Trials Network; A. Thorne, MSc, Senior Biostatistician, CIHR Canadian HIV Trials Network, School of Population and Public Health, UBC; J. Singer, PhD, Professor, School of Population and Public Health, UBC, and Centre for Health Evaluation and Outcome Sciences; J.A. Kopec, MD, MSc, PhD, Associate Professor, School of Population and Public Health, UBC, and Research Scientist, Arthritis Research Canada; J.M. Esdaile, MD, MPH, Professor, Department of Medicine, UBC, and Scientific Director, Arthritis Research Canada; J. Cibere, MD, PhD, Associate Professor, Department of Medicine, UBC, and Senior Research Scientist, Arthritis Research Canada. Address correspondence to Dr. C. Chin, 802-1200 Burrard St., Vancouver, British Columbia V6Z 2C7, Canada. E-mail: carson.c.chin@gmail.com. Accepted for publication July 18, 2018.
Ali Guermazi
From the Department of Medicine, the Division of Rheumatology, the Department of Radiology and the School of Population and Public Health, University of British Columbia, Vancouver; Arthritis Research Canada, Vancouver; Canadian Institutes of Health Research HIV Trials Network, Vancouver; Centre for Health Evaluation and Outcomes Sciences, Vancouver, British Columbia, Canada; Department of Radiology, Boston University Medical Center, Boston, Massachusetts, USA. This research was funded by grants from the Canadian Institutes of Health Research (89890, 89997), the Canadian Arthritis Network (01-MNO-09N), and the Arthritis Society (TAS04/0063). Dr. Cibere’s work was supported by an investigator award from the Arthritis Society (INS-12-027). C. Chin, MD, FRCPC, Division of Rheumatology, University of British Columbia; E.C. Sayre, PhD, Research Associate, Arthritis Research Canada; A. Guermazi, MD, Professor, Department of Radiology, Boston University Medical Center; S. Nicolaou, MD, Assistant Professor, Department of Radiology, University of British Columbia (UBC), Director of Emergency/Trauma Imaging, Vancouver General Hospital; H. Wong, PhD, Associate Professor, School of Population and Public Health, UBC, and Associate Head, Data and Methodology, CIHR Canadian HIV Trials Network; A. Thorne, MSc, Senior Biostatistician, CIHR Canadian HIV Trials Network, School of Population and Public Health, UBC; J. Singer, PhD, Professor, School of Population and Public Health, UBC, and Centre for Health Evaluation and Outcome Sciences; J.A. Kopec, MD, MSc, PhD, Associate Professor, School of Population and Public Health, UBC, and Research Scientist, Arthritis Research Canada; J.M. Esdaile, MD, MPH, Professor, Department of Medicine, UBC, and Scientific Director, Arthritis Research Canada; J. Cibere, MD, PhD, Associate Professor, Department of Medicine, UBC, and Senior Research Scientist, Arthritis Research Canada. Address correspondence to Dr. C. Chin, 802-1200 Burrard St., Vancouver, British Columbia V6Z 2C7, Canada. E-mail: carson.c.chin@gmail.com. Accepted for publication July 18, 2018.
Savvas Nicolaou
From the Department of Medicine, the Division of Rheumatology, the Department of Radiology and the School of Population and Public Health, University of British Columbia, Vancouver; Arthritis Research Canada, Vancouver; Canadian Institutes of Health Research HIV Trials Network, Vancouver; Centre for Health Evaluation and Outcomes Sciences, Vancouver, British Columbia, Canada; Department of Radiology, Boston University Medical Center, Boston, Massachusetts, USA. This research was funded by grants from the Canadian Institutes of Health Research (89890, 89997), the Canadian Arthritis Network (01-MNO-09N), and the Arthritis Society (TAS04/0063). Dr. Cibere’s work was supported by an investigator award from the Arthritis Society (INS-12-027). C. Chin, MD, FRCPC, Division of Rheumatology, University of British Columbia; E.C. Sayre, PhD, Research Associate, Arthritis Research Canada; A. Guermazi, MD, Professor, Department of Radiology, Boston University Medical Center; S. Nicolaou, MD, Assistant Professor, Department of Radiology, University of British Columbia (UBC), Director of Emergency/Trauma Imaging, Vancouver General Hospital; H. Wong, PhD, Associate Professor, School of Population and Public Health, UBC, and Associate Head, Data and Methodology, CIHR Canadian HIV Trials Network; A. Thorne, MSc, Senior Biostatistician, CIHR Canadian HIV Trials Network, School of Population and Public Health, UBC; J. Singer, PhD, Professor, School of Population and Public Health, UBC, and Centre for Health Evaluation and Outcome Sciences; J.A. Kopec, MD, MSc, PhD, Associate Professor, School of Population and Public Health, UBC, and Research Scientist, Arthritis Research Canada; J.M. Esdaile, MD, MPH, Professor, Department of Medicine, UBC, and Scientific Director, Arthritis Research Canada; J. Cibere, MD, PhD, Associate Professor, Department of Medicine, UBC, and Senior Research Scientist, Arthritis Research Canada. Address correspondence to Dr. C. Chin, 802-1200 Burrard St., Vancouver, British Columbia V6Z 2C7, Canada. E-mail: carson.c.chin@gmail.com. Accepted for publication July 18, 2018.
John M. Esdaile
From the Department of Medicine, the Division of Rheumatology, the Department of Radiology and the School of Population and Public Health, University of British Columbia, Vancouver; Arthritis Research Canada, Vancouver; Canadian Institutes of Health Research HIV Trials Network, Vancouver; Centre for Health Evaluation and Outcomes Sciences, Vancouver, British Columbia, Canada; Department of Radiology, Boston University Medical Center, Boston, Massachusetts, USA. This research was funded by grants from the Canadian Institutes of Health Research (89890, 89997), the Canadian Arthritis Network (01-MNO-09N), and the Arthritis Society (TAS04/0063). Dr. Cibere’s work was supported by an investigator award from the Arthritis Society (INS-12-027). C. Chin, MD, FRCPC, Division of Rheumatology, University of British Columbia; E.C. Sayre, PhD, Research Associate, Arthritis Research Canada; A. Guermazi, MD, Professor, Department of Radiology, Boston University Medical Center; S. Nicolaou, MD, Assistant Professor, Department of Radiology, University of British Columbia (UBC), Director of Emergency/Trauma Imaging, Vancouver General Hospital; H. Wong, PhD, Associate Professor, School of Population and Public Health, UBC, and Associate Head, Data and Methodology, CIHR Canadian HIV Trials Network; A. Thorne, MSc, Senior Biostatistician, CIHR Canadian HIV Trials Network, School of Population and Public Health, UBC; J. Singer, PhD, Professor, School of Population and Public Health, UBC, and Centre for Health Evaluation and Outcome Sciences; J.A. Kopec, MD, MSc, PhD, Associate Professor, School of Population and Public Health, UBC, and Research Scientist, Arthritis Research Canada; J.M. Esdaile, MD, MPH, Professor, Department of Medicine, UBC, and Scientific Director, Arthritis Research Canada; J. Cibere, MD, PhD, Associate Professor, Department of Medicine, UBC, and Senior Research Scientist, Arthritis Research Canada. Address correspondence to Dr. C. Chin, 802-1200 Burrard St., Vancouver, British Columbia V6Z 2C7, Canada. E-mail: carson.c.chin@gmail.com. Accepted for publication July 18, 2018.
Jacek Kopec
From the Department of Medicine, the Division of Rheumatology, the Department of Radiology and the School of Population and Public Health, University of British Columbia, Vancouver; Arthritis Research Canada, Vancouver; Canadian Institutes of Health Research HIV Trials Network, Vancouver; Centre for Health Evaluation and Outcomes Sciences, Vancouver, British Columbia, Canada; Department of Radiology, Boston University Medical Center, Boston, Massachusetts, USA. This research was funded by grants from the Canadian Institutes of Health Research (89890, 89997), the Canadian Arthritis Network (01-MNO-09N), and the Arthritis Society (TAS04/0063). Dr. Cibere’s work was supported by an investigator award from the Arthritis Society (INS-12-027). C. Chin, MD, FRCPC, Division of Rheumatology, University of British Columbia; E.C. Sayre, PhD, Research Associate, Arthritis Research Canada; A. Guermazi, MD, Professor, Department of Radiology, Boston University Medical Center; S. Nicolaou, MD, Assistant Professor, Department of Radiology, University of British Columbia (UBC), Director of Emergency/Trauma Imaging, Vancouver General Hospital; H. Wong, PhD, Associate Professor, School of Population and Public Health, UBC, and Associate Head, Data and Methodology, CIHR Canadian HIV Trials Network; A. Thorne, MSc, Senior Biostatistician, CIHR Canadian HIV Trials Network, School of Population and Public Health, UBC; J. Singer, PhD, Professor, School of Population and Public Health, UBC, and Centre for Health Evaluation and Outcome Sciences; J.A. Kopec, MD, MSc, PhD, Associate Professor, School of Population and Public Health, UBC, and Research Scientist, Arthritis Research Canada; J.M. Esdaile, MD, MPH, Professor, Department of Medicine, UBC, and Scientific Director, Arthritis Research Canada; J. Cibere, MD, PhD, Associate Professor, Department of Medicine, UBC, and Senior Research Scientist, Arthritis Research Canada. Address correspondence to Dr. C. Chin, 802-1200 Burrard St., Vancouver, British Columbia V6Z 2C7, Canada. E-mail: carson.c.chin@gmail.com. Accepted for publication July 18, 2018.
Anona Thorne
From the Department of Medicine, the Division of Rheumatology, the Department of Radiology and the School of Population and Public Health, University of British Columbia, Vancouver; Arthritis Research Canada, Vancouver; Canadian Institutes of Health Research HIV Trials Network, Vancouver; Centre for Health Evaluation and Outcomes Sciences, Vancouver, British Columbia, Canada; Department of Radiology, Boston University Medical Center, Boston, Massachusetts, USA. This research was funded by grants from the Canadian Institutes of Health Research (89890, 89997), the Canadian Arthritis Network (01-MNO-09N), and the Arthritis Society (TAS04/0063). Dr. Cibere’s work was supported by an investigator award from the Arthritis Society (INS-12-027). C. Chin, MD, FRCPC, Division of Rheumatology, University of British Columbia; E.C. Sayre, PhD, Research Associate, Arthritis Research Canada; A. Guermazi, MD, Professor, Department of Radiology, Boston University Medical Center; S. Nicolaou, MD, Assistant Professor, Department of Radiology, University of British Columbia (UBC), Director of Emergency/Trauma Imaging, Vancouver General Hospital; H. Wong, PhD, Associate Professor, School of Population and Public Health, UBC, and Associate Head, Data and Methodology, CIHR Canadian HIV Trials Network; A. Thorne, MSc, Senior Biostatistician, CIHR Canadian HIV Trials Network, School of Population and Public Health, UBC; J. Singer, PhD, Professor, School of Population and Public Health, UBC, and Centre for Health Evaluation and Outcome Sciences; J.A. Kopec, MD, MSc, PhD, Associate Professor, School of Population and Public Health, UBC, and Research Scientist, Arthritis Research Canada; J.M. Esdaile, MD, MPH, Professor, Department of Medicine, UBC, and Scientific Director, Arthritis Research Canada; J. Cibere, MD, PhD, Associate Professor, Department of Medicine, UBC, and Senior Research Scientist, Arthritis Research Canada. Address correspondence to Dr. C. Chin, 802-1200 Burrard St., Vancouver, British Columbia V6Z 2C7, Canada. E-mail: carson.c.chin@gmail.com. Accepted for publication July 18, 2018.
Joel Singer
From the Department of Medicine, the Division of Rheumatology, the Department of Radiology and the School of Population and Public Health, University of British Columbia, Vancouver; Arthritis Research Canada, Vancouver; Canadian Institutes of Health Research HIV Trials Network, Vancouver; Centre for Health Evaluation and Outcomes Sciences, Vancouver, British Columbia, Canada; Department of Radiology, Boston University Medical Center, Boston, Massachusetts, USA. This research was funded by grants from the Canadian Institutes of Health Research (89890, 89997), the Canadian Arthritis Network (01-MNO-09N), and the Arthritis Society (TAS04/0063). Dr. Cibere’s work was supported by an investigator award from the Arthritis Society (INS-12-027). C. Chin, MD, FRCPC, Division of Rheumatology, University of British Columbia; E.C. Sayre, PhD, Research Associate, Arthritis Research Canada; A. Guermazi, MD, Professor, Department of Radiology, Boston University Medical Center; S. Nicolaou, MD, Assistant Professor, Department of Radiology, University of British Columbia (UBC), Director of Emergency/Trauma Imaging, Vancouver General Hospital; H. Wong, PhD, Associate Professor, School of Population and Public Health, UBC, and Associate Head, Data and Methodology, CIHR Canadian HIV Trials Network; A. Thorne, MSc, Senior Biostatistician, CIHR Canadian HIV Trials Network, School of Population and Public Health, UBC; J. Singer, PhD, Professor, School of Population and Public Health, UBC, and Centre for Health Evaluation and Outcome Sciences; J.A. Kopec, MD, MSc, PhD, Associate Professor, School of Population and Public Health, UBC, and Research Scientist, Arthritis Research Canada; J.M. Esdaile, MD, MPH, Professor, Department of Medicine, UBC, and Scientific Director, Arthritis Research Canada; J. Cibere, MD, PhD, Associate Professor, Department of Medicine, UBC, and Senior Research Scientist, Arthritis Research Canada. Address correspondence to Dr. C. Chin, 802-1200 Burrard St., Vancouver, British Columbia V6Z 2C7, Canada. E-mail: carson.c.chin@gmail.com. Accepted for publication July 18, 2018.
Hubert Wong
From the Department of Medicine, the Division of Rheumatology, the Department of Radiology and the School of Population and Public Health, University of British Columbia, Vancouver; Arthritis Research Canada, Vancouver; Canadian Institutes of Health Research HIV Trials Network, Vancouver; Centre for Health Evaluation and Outcomes Sciences, Vancouver, British Columbia, Canada; Department of Radiology, Boston University Medical Center, Boston, Massachusetts, USA. This research was funded by grants from the Canadian Institutes of Health Research (89890, 89997), the Canadian Arthritis Network (01-MNO-09N), and the Arthritis Society (TAS04/0063). Dr. Cibere’s work was supported by an investigator award from the Arthritis Society (INS-12-027). C. Chin, MD, FRCPC, Division of Rheumatology, University of British Columbia; E.C. Sayre, PhD, Research Associate, Arthritis Research Canada; A. Guermazi, MD, Professor, Department of Radiology, Boston University Medical Center; S. Nicolaou, MD, Assistant Professor, Department of Radiology, University of British Columbia (UBC), Director of Emergency/Trauma Imaging, Vancouver General Hospital; H. Wong, PhD, Associate Professor, School of Population and Public Health, UBC, and Associate Head, Data and Methodology, CIHR Canadian HIV Trials Network; A. Thorne, MSc, Senior Biostatistician, CIHR Canadian HIV Trials Network, School of Population and Public Health, UBC; J. Singer, PhD, Professor, School of Population and Public Health, UBC, and Centre for Health Evaluation and Outcome Sciences; J.A. Kopec, MD, MSc, PhD, Associate Professor, School of Population and Public Health, UBC, and Research Scientist, Arthritis Research Canada; J.M. Esdaile, MD, MPH, Professor, Department of Medicine, UBC, and Scientific Director, Arthritis Research Canada; J. Cibere, MD, PhD, Associate Professor, Department of Medicine, UBC, and Senior Research Scientist, Arthritis Research Canada. Address correspondence to Dr. C. Chin, 802-1200 Burrard St., Vancouver, British Columbia V6Z 2C7, Canada. E-mail: carson.c.chin@gmail.com. Accepted for publication July 18, 2018.
Jolanda Cibere
From the Department of Medicine, the Division of Rheumatology, the Department of Radiology and the School of Population and Public Health, University of British Columbia, Vancouver; Arthritis Research Canada, Vancouver; Canadian Institutes of Health Research HIV Trials Network, Vancouver; Centre for Health Evaluation and Outcomes Sciences, Vancouver, British Columbia, Canada; Department of Radiology, Boston University Medical Center, Boston, Massachusetts, USA. This research was funded by grants from the Canadian Institutes of Health Research (89890, 89997), the Canadian Arthritis Network (01-MNO-09N), and the Arthritis Society (TAS04/0063). Dr. Cibere’s work was supported by an investigator award from the Arthritis Society (INS-12-027). C. Chin, MD, FRCPC, Division of Rheumatology, University of British Columbia; E.C. Sayre, PhD, Research Associate, Arthritis Research Canada; A. Guermazi, MD, Professor, Department of Radiology, Boston University Medical Center; S. Nicolaou, MD, Assistant Professor, Department of Radiology, University of British Columbia (UBC), Director of Emergency/Trauma Imaging, Vancouver General Hospital; H. Wong, PhD, Associate Professor, School of Population and Public Health, UBC, and Associate Head, Data and Methodology, CIHR Canadian HIV Trials Network; A. Thorne, MSc, Senior Biostatistician, CIHR Canadian HIV Trials Network, School of Population and Public Health, UBC; J. Singer, PhD, Professor, School of Population and Public Health, UBC, and Centre for Health Evaluation and Outcome Sciences; J.A. Kopec, MD, MSc, PhD, Associate Professor, School of Population and Public Health, UBC, and Research Scientist, Arthritis Research Canada; J.M. Esdaile, MD, MPH, Professor, Department of Medicine, UBC, and Scientific Director, Arthritis Research Canada; J. Cibere, MD, PhD, Associate Professor, Department of Medicine, UBC, and Senior Research Scientist, Arthritis Research Canada. Address correspondence to Dr. C. Chin, 802-1200 Burrard St., Vancouver, British Columbia V6Z 2C7, Canada. E-mail: carson.c.chin@gmail.com. Accepted for publication July 18, 2018.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Quadriceps Weakness and the Risk of Knee Cartilage Loss Seen on Magnetic Resonance Imaging in a Population-based Cohort with Knee Pain
Carson Chin, Eric C. Sayre, Ali Guermazi, Savvas Nicolaou, John M. Esdaile, Jacek Kopec, Anona Thorne, Joel Singer, Hubert Wong, Jolanda Cibere
The Journal of Rheumatology Oct 2018, jrheum.170875; DOI: 10.3899/jrheum.170875
Quadriceps Weakness and the Risk of Knee Cartilage Loss Seen on Magnetic Resonance Imaging in a Population-based Cohort with Knee Pain
Carson Chin, Eric C. Sayre, Ali Guermazi, Savvas Nicolaou, John M. Esdaile, Jacek Kopec, Anona Thorne, Joel Singer, Hubert Wong, Jolanda Cibere
The Journal of Rheumatology Oct 2018, jrheum.170875; DOI: 10.3899/jrheum.170875