Research ArticleArticle
Bone Marrow–derived Endothelial Progenitor Cells Are Associated with Bone Mass and Strength
Qun Cheng, Shangjin Lin, Bo Bi, Xin Jiang, Hongli Shi, Yongqian Fan, Weilong Lin, Yuefeng Zhu and Fengjian Yang
The Journal of Rheumatology September 2018, jrheum.171226; DOI: https://doi.org/10.3899/jrheum.171226
Qun Cheng
From the Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; the Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; and the Central Laboratory, Huadong Hospital, affiliated to Fudan University, Shanghai, China. Supported by the National Natural Science Foundation of China (No. 81471089), Shanghai Municipal Commission of Health (2013ZYJB0801), Natural Science Foundation of Shanghai China (16411954600), and Shanghai Key Laboratory of Clinical Geriatric Medicine (13dz2260700). Q. Cheng, MD, PhD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; S. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; B. Bi, MD, PhD, Central Lab, Huadong Hospital, affiliated to Fudan University; X. Jiang, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; H. Shi, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; Y. Fan, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; W. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; Y. Zhu, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; F. Yang, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University. Qun Cheng and Shangjin Lin are co-first authors of this article. Address correspondence to Dr. Q. Cheng, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, 221 West Yan An Road, Shanghai 200040, China. E-mail: quncheng_2014@163.com. Accepted for publication May 18, 2018.
Shangjin Lin
From the Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; the Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; and the Central Laboratory, Huadong Hospital, affiliated to Fudan University, Shanghai, China. Supported by the National Natural Science Foundation of China (No. 81471089), Shanghai Municipal Commission of Health (2013ZYJB0801), Natural Science Foundation of Shanghai China (16411954600), and Shanghai Key Laboratory of Clinical Geriatric Medicine (13dz2260700). Q. Cheng, MD, PhD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; S. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; B. Bi, MD, PhD, Central Lab, Huadong Hospital, affiliated to Fudan University; X. Jiang, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; H. Shi, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; Y. Fan, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; W. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; Y. Zhu, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; F. Yang, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University. Qun Cheng and Shangjin Lin are co-first authors of this article. Address correspondence to Dr. Q. Cheng, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, 221 West Yan An Road, Shanghai 200040, China. E-mail: quncheng_2014@163.com. Accepted for publication May 18, 2018.
Bo Bi
From the Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; the Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; and the Central Laboratory, Huadong Hospital, affiliated to Fudan University, Shanghai, China. Supported by the National Natural Science Foundation of China (No. 81471089), Shanghai Municipal Commission of Health (2013ZYJB0801), Natural Science Foundation of Shanghai China (16411954600), and Shanghai Key Laboratory of Clinical Geriatric Medicine (13dz2260700). Q. Cheng, MD, PhD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; S. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; B. Bi, MD, PhD, Central Lab, Huadong Hospital, affiliated to Fudan University; X. Jiang, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; H. Shi, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; Y. Fan, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; W. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; Y. Zhu, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; F. Yang, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University. Qun Cheng and Shangjin Lin are co-first authors of this article. Address correspondence to Dr. Q. Cheng, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, 221 West Yan An Road, Shanghai 200040, China. E-mail: quncheng_2014@163.com. Accepted for publication May 18, 2018.
Xin Jiang
From the Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; the Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; and the Central Laboratory, Huadong Hospital, affiliated to Fudan University, Shanghai, China. Supported by the National Natural Science Foundation of China (No. 81471089), Shanghai Municipal Commission of Health (2013ZYJB0801), Natural Science Foundation of Shanghai China (16411954600), and Shanghai Key Laboratory of Clinical Geriatric Medicine (13dz2260700). Q. Cheng, MD, PhD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; S. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; B. Bi, MD, PhD, Central Lab, Huadong Hospital, affiliated to Fudan University; X. Jiang, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; H. Shi, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; Y. Fan, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; W. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; Y. Zhu, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; F. Yang, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University. Qun Cheng and Shangjin Lin are co-first authors of this article. Address correspondence to Dr. Q. Cheng, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, 221 West Yan An Road, Shanghai 200040, China. E-mail: quncheng_2014@163.com. Accepted for publication May 18, 2018.
Hongli Shi
From the Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; the Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; and the Central Laboratory, Huadong Hospital, affiliated to Fudan University, Shanghai, China. Supported by the National Natural Science Foundation of China (No. 81471089), Shanghai Municipal Commission of Health (2013ZYJB0801), Natural Science Foundation of Shanghai China (16411954600), and Shanghai Key Laboratory of Clinical Geriatric Medicine (13dz2260700). Q. Cheng, MD, PhD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; S. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; B. Bi, MD, PhD, Central Lab, Huadong Hospital, affiliated to Fudan University; X. Jiang, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; H. Shi, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; Y. Fan, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; W. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; Y. Zhu, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; F. Yang, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University. Qun Cheng and Shangjin Lin are co-first authors of this article. Address correspondence to Dr. Q. Cheng, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, 221 West Yan An Road, Shanghai 200040, China. E-mail: quncheng_2014@163.com. Accepted for publication May 18, 2018.
Yongqian Fan
From the Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; the Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; and the Central Laboratory, Huadong Hospital, affiliated to Fudan University, Shanghai, China. Supported by the National Natural Science Foundation of China (No. 81471089), Shanghai Municipal Commission of Health (2013ZYJB0801), Natural Science Foundation of Shanghai China (16411954600), and Shanghai Key Laboratory of Clinical Geriatric Medicine (13dz2260700). Q. Cheng, MD, PhD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; S. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; B. Bi, MD, PhD, Central Lab, Huadong Hospital, affiliated to Fudan University; X. Jiang, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; H. Shi, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; Y. Fan, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; W. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; Y. Zhu, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; F. Yang, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University. Qun Cheng and Shangjin Lin are co-first authors of this article. Address correspondence to Dr. Q. Cheng, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, 221 West Yan An Road, Shanghai 200040, China. E-mail: quncheng_2014@163.com. Accepted for publication May 18, 2018.
Weilong Lin
From the Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; the Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; and the Central Laboratory, Huadong Hospital, affiliated to Fudan University, Shanghai, China. Supported by the National Natural Science Foundation of China (No. 81471089), Shanghai Municipal Commission of Health (2013ZYJB0801), Natural Science Foundation of Shanghai China (16411954600), and Shanghai Key Laboratory of Clinical Geriatric Medicine (13dz2260700). Q. Cheng, MD, PhD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; S. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; B. Bi, MD, PhD, Central Lab, Huadong Hospital, affiliated to Fudan University; X. Jiang, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; H. Shi, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; Y. Fan, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; W. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; Y. Zhu, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; F. Yang, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University. Qun Cheng and Shangjin Lin are co-first authors of this article. Address correspondence to Dr. Q. Cheng, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, 221 West Yan An Road, Shanghai 200040, China. E-mail: quncheng_2014@163.com. Accepted for publication May 18, 2018.
Yuefeng Zhu
From the Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; the Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; and the Central Laboratory, Huadong Hospital, affiliated to Fudan University, Shanghai, China. Supported by the National Natural Science Foundation of China (No. 81471089), Shanghai Municipal Commission of Health (2013ZYJB0801), Natural Science Foundation of Shanghai China (16411954600), and Shanghai Key Laboratory of Clinical Geriatric Medicine (13dz2260700). Q. Cheng, MD, PhD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; S. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; B. Bi, MD, PhD, Central Lab, Huadong Hospital, affiliated to Fudan University; X. Jiang, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; H. Shi, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; Y. Fan, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; W. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; Y. Zhu, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; F. Yang, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University. Qun Cheng and Shangjin Lin are co-first authors of this article. Address correspondence to Dr. Q. Cheng, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, 221 West Yan An Road, Shanghai 200040, China. E-mail: quncheng_2014@163.com. Accepted for publication May 18, 2018.
Fengjian Yang
From the Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; the Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; and the Central Laboratory, Huadong Hospital, affiliated to Fudan University, Shanghai, China. Supported by the National Natural Science Foundation of China (No. 81471089), Shanghai Municipal Commission of Health (2013ZYJB0801), Natural Science Foundation of Shanghai China (16411954600), and Shanghai Key Laboratory of Clinical Geriatric Medicine (13dz2260700). Q. Cheng, MD, PhD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; S. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; B. Bi, MD, PhD, Central Lab, Huadong Hospital, affiliated to Fudan University; X. Jiang, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; H. Shi, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; Y. Fan, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; W. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; Y. Zhu, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; F. Yang, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University. Qun Cheng and Shangjin Lin are co-first authors of this article. Address correspondence to Dr. Q. Cheng, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, 221 West Yan An Road, Shanghai 200040, China. E-mail: quncheng_2014@163.com. Accepted for publication May 18, 2018.
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- Published online September 1, 2018.
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© 2018 The Journal of Rheumatology
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- Qun Cheng,
- Shangjin Lin,
- Bo Bi,
- Xin Jiang,
- Hongli Shi,
- Yongqian Fan,
- Weilong Lin,
- Yuefeng Zhu and
- Fengjian Yang
- From the Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; the Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; and the Central Laboratory, Huadong Hospital, affiliated to Fudan University, Shanghai, China.
Supported by the National Natural Science Foundation of China (No. 81471089), Shanghai Municipal Commission of Health (2013ZYJB0801), Natural Science Foundation of Shanghai China (16411954600), and Shanghai Key Laboratory of Clinical Geriatric Medicine (13dz2260700).
Q. Cheng, MD, PhD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; S. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; B. Bi, MD, PhD, Central Lab, Huadong Hospital, affiliated to Fudan University; X. Jiang, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; H. Shi, MD, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute; Y. Fan, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; W. Lin, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; Y. Zhu, MD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University; F. Yang, MD, PhD, Department of Orthopedics, Huadong Hospital, affiliated to Fudan University.
Qun Cheng and Shangjin Lin are co-first authors of this article.
Address correspondence to Dr. Q. Cheng, Department of Osteoporosis and Bone Disease, Huadong Hospital, affiliated to Fudan University, Research Section of Geriatric Metabolic Bone Disease, Shanghai Geriatric Institute, 221 West Yan An Road, Shanghai 200040, China. E-mail: quncheng_2014@163.com.
Accepted for publication May 18, 2018.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Bone Marrow–derived Endothelial Progenitor Cells Are Associated with Bone Mass and Strength
Qun Cheng, Shangjin Lin, Bo Bi, Xin Jiang, Hongli Shi, Yongqian Fan, Weilong Lin, Yuefeng Zhu, Fengjian Yang
The Journal of Rheumatology Sep 2018, jrheum.171226; DOI: 10.3899/jrheum.171226