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Research ArticleArticle

Associations Between Cardiorespiratory Fitness and Arterial Stiffness in Ankylosing Spondylitis: A Cross-sectional Study

Inger Jorid Berg, Anne Grete Semb, Silje H. Sveaas, Camilla Fongen, Désirée van der Heijde, Tore K. Kvien, Hanne Dagfinrud and Sella A. Provan
The Journal of Rheumatology July 2018, jrheum.170726; DOI: https://doi.org/10.3899/jrheum.170726
Inger Jorid Berg
From the Department of Rheumatology, and the Preventive Cardio-Rheuma Clinic, Diakonhjemmet Hospital, Oslo, Norway; the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by The Norwegian Rheumatism Association. I.J. Berg, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.H. Sveaas, PhD, Department of Rheumatology, Diakonhjemmet Hospital; C. Fongen, MSc, Department of Rheumatology, Diakonhjemmet Hospital; T.K. Kvien, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; H. Dagfinrud, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.A. Provan, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; A.G. Semb, MD, PhD, Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital; D. van der Heijde, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital, and Department of Rheumatology, Leiden University Medical Center. Address correspondence to Dr. I.J. Berg, Diakonhjemmet Hospital, Box 23 Vinderen, N-0319 Oslo, Norway. E-mail: ingerjoridberg@gmail.com. Accepted for publication April 6, 2018.
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Anne Grete Semb
From the Department of Rheumatology, and the Preventive Cardio-Rheuma Clinic, Diakonhjemmet Hospital, Oslo, Norway; the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by The Norwegian Rheumatism Association. I.J. Berg, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.H. Sveaas, PhD, Department of Rheumatology, Diakonhjemmet Hospital; C. Fongen, MSc, Department of Rheumatology, Diakonhjemmet Hospital; T.K. Kvien, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; H. Dagfinrud, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.A. Provan, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; A.G. Semb, MD, PhD, Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital; D. van der Heijde, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital, and Department of Rheumatology, Leiden University Medical Center. Address correspondence to Dr. I.J. Berg, Diakonhjemmet Hospital, Box 23 Vinderen, N-0319 Oslo, Norway. E-mail: ingerjoridberg@gmail.com. Accepted for publication April 6, 2018.
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Silje H. Sveaas
From the Department of Rheumatology, and the Preventive Cardio-Rheuma Clinic, Diakonhjemmet Hospital, Oslo, Norway; the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by The Norwegian Rheumatism Association. I.J. Berg, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.H. Sveaas, PhD, Department of Rheumatology, Diakonhjemmet Hospital; C. Fongen, MSc, Department of Rheumatology, Diakonhjemmet Hospital; T.K. Kvien, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; H. Dagfinrud, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.A. Provan, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; A.G. Semb, MD, PhD, Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital; D. van der Heijde, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital, and Department of Rheumatology, Leiden University Medical Center. Address correspondence to Dr. I.J. Berg, Diakonhjemmet Hospital, Box 23 Vinderen, N-0319 Oslo, Norway. E-mail: ingerjoridberg@gmail.com. Accepted for publication April 6, 2018.
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Camilla Fongen
From the Department of Rheumatology, and the Preventive Cardio-Rheuma Clinic, Diakonhjemmet Hospital, Oslo, Norway; the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by The Norwegian Rheumatism Association. I.J. Berg, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.H. Sveaas, PhD, Department of Rheumatology, Diakonhjemmet Hospital; C. Fongen, MSc, Department of Rheumatology, Diakonhjemmet Hospital; T.K. Kvien, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; H. Dagfinrud, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.A. Provan, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; A.G. Semb, MD, PhD, Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital; D. van der Heijde, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital, and Department of Rheumatology, Leiden University Medical Center. Address correspondence to Dr. I.J. Berg, Diakonhjemmet Hospital, Box 23 Vinderen, N-0319 Oslo, Norway. E-mail: ingerjoridberg@gmail.com. Accepted for publication April 6, 2018.
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Désirée van der Heijde
From the Department of Rheumatology, and the Preventive Cardio-Rheuma Clinic, Diakonhjemmet Hospital, Oslo, Norway; the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by The Norwegian Rheumatism Association. I.J. Berg, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.H. Sveaas, PhD, Department of Rheumatology, Diakonhjemmet Hospital; C. Fongen, MSc, Department of Rheumatology, Diakonhjemmet Hospital; T.K. Kvien, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; H. Dagfinrud, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.A. Provan, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; A.G. Semb, MD, PhD, Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital; D. van der Heijde, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital, and Department of Rheumatology, Leiden University Medical Center. Address correspondence to Dr. I.J. Berg, Diakonhjemmet Hospital, Box 23 Vinderen, N-0319 Oslo, Norway. E-mail: ingerjoridberg@gmail.com. Accepted for publication April 6, 2018.
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Tore K. Kvien
From the Department of Rheumatology, and the Preventive Cardio-Rheuma Clinic, Diakonhjemmet Hospital, Oslo, Norway; the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by The Norwegian Rheumatism Association. I.J. Berg, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.H. Sveaas, PhD, Department of Rheumatology, Diakonhjemmet Hospital; C. Fongen, MSc, Department of Rheumatology, Diakonhjemmet Hospital; T.K. Kvien, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; H. Dagfinrud, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.A. Provan, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; A.G. Semb, MD, PhD, Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital; D. van der Heijde, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital, and Department of Rheumatology, Leiden University Medical Center. Address correspondence to Dr. I.J. Berg, Diakonhjemmet Hospital, Box 23 Vinderen, N-0319 Oslo, Norway. E-mail: ingerjoridberg@gmail.com. Accepted for publication April 6, 2018.
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Hanne Dagfinrud
From the Department of Rheumatology, and the Preventive Cardio-Rheuma Clinic, Diakonhjemmet Hospital, Oslo, Norway; the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by The Norwegian Rheumatism Association. I.J. Berg, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.H. Sveaas, PhD, Department of Rheumatology, Diakonhjemmet Hospital; C. Fongen, MSc, Department of Rheumatology, Diakonhjemmet Hospital; T.K. Kvien, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; H. Dagfinrud, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.A. Provan, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; A.G. Semb, MD, PhD, Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital; D. van der Heijde, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital, and Department of Rheumatology, Leiden University Medical Center. Address correspondence to Dr. I.J. Berg, Diakonhjemmet Hospital, Box 23 Vinderen, N-0319 Oslo, Norway. E-mail: ingerjoridberg@gmail.com. Accepted for publication April 6, 2018.
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Sella A. Provan
From the Department of Rheumatology, and the Preventive Cardio-Rheuma Clinic, Diakonhjemmet Hospital, Oslo, Norway; the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by The Norwegian Rheumatism Association. I.J. Berg, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.H. Sveaas, PhD, Department of Rheumatology, Diakonhjemmet Hospital; C. Fongen, MSc, Department of Rheumatology, Diakonhjemmet Hospital; T.K. Kvien, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; H. Dagfinrud, PhD, Department of Rheumatology, Diakonhjemmet Hospital; S.A. Provan, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; A.G. Semb, MD, PhD, Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital; D. van der Heijde, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital, and Department of Rheumatology, Leiden University Medical Center. Address correspondence to Dr. I.J. Berg, Diakonhjemmet Hospital, Box 23 Vinderen, N-0319 Oslo, Norway. E-mail: ingerjoridberg@gmail.com. Accepted for publication April 6, 2018.
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Abstract

Objective To assess associations between cardiorespiratory fitness (CRF), measured as peak oxygen uptake (VO2peak), and cardiovascular disease (CVD) risk, measured by arterial stiffness, in patients with ankylosing spondylitis (AS).

Methods VO2peak was assessed by a maximal walking test on a treadmill. Arterial stiffness was measured noninvasively (Sphygmocor apparatus). Cross-sectional associations between VO2peak and arterial stiffness were analyzed using backward multivariable linear regression.

Results Among 118 participating patients, there were significant inverse associations between VO2peak and arterial stiffness, independent of traditional CVD risk factors and measures of disease activity.

Conclusion Reduced CRF may be related to increased risk of CVD in AS.

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The Journal of Rheumatology
Vol. 49, Issue 7
1 Jul 2022
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Associations Between Cardiorespiratory Fitness and Arterial Stiffness in Ankylosing Spondylitis: A Cross-sectional Study
Inger Jorid Berg, Anne Grete Semb, Silje H. Sveaas, Camilla Fongen, Désirée van der Heijde, Tore K. Kvien, Hanne Dagfinrud, Sella A. Provan
The Journal of Rheumatology Jul 2018, jrheum.170726; DOI: 10.3899/jrheum.170726

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Associations Between Cardiorespiratory Fitness and Arterial Stiffness in Ankylosing Spondylitis: A Cross-sectional Study
Inger Jorid Berg, Anne Grete Semb, Silje H. Sveaas, Camilla Fongen, Désirée van der Heijde, Tore K. Kvien, Hanne Dagfinrud, Sella A. Provan
The Journal of Rheumatology Jul 2018, jrheum.170726; DOI: 10.3899/jrheum.170726
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