Research ArticleArticle
Fecal Calprotectin to Detect Inflammatory Bowel Disease in Juvenile Idiopathic Arthritis
Giovanna Ferrara, Serena Pastore, Lara Sancin, Lucio Torelli, Oriano Radillo, Matteo Bramuzzo, Chiara Bibalo, Alberto Tommasini, Alessandro Ventura and Andrea Taddio
The Journal of Rheumatology June 2018, jrheum.171200; DOI: https://doi.org/10.3899/jrheum.171200
Giovanna Ferrara
From the University of Trieste; Institute for Maternal and Child Health – Institute for Research and Health Care (IRCCS) Burlo Garofolo, Trieste, Italy. G. Ferrara, MD, University of Trieste; S. Pastore, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; L. Sancin, MD, University of Trieste; L. Torelli, MSs, University of Trieste; O. Radillo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; M. Bramuzzo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; C. Bibalo, MD, University of Trieste; A. Tommasini, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Ventura, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Taddio, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Address correspondence to Dr. A. Taddio, MD, University of Trieste and Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34100, Trieste, Italy. E-mail: andrea.taddio@burlo.trieste.it Accepted for publication March 7, 2018.
Serena Pastore
From the University of Trieste; Institute for Maternal and Child Health – Institute for Research and Health Care (IRCCS) Burlo Garofolo, Trieste, Italy. G. Ferrara, MD, University of Trieste; S. Pastore, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; L. Sancin, MD, University of Trieste; L. Torelli, MSs, University of Trieste; O. Radillo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; M. Bramuzzo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; C. Bibalo, MD, University of Trieste; A. Tommasini, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Ventura, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Taddio, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Address correspondence to Dr. A. Taddio, MD, University of Trieste and Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34100, Trieste, Italy. E-mail: andrea.taddio@burlo.trieste.it Accepted for publication March 7, 2018.
Lara Sancin
From the University of Trieste; Institute for Maternal and Child Health – Institute for Research and Health Care (IRCCS) Burlo Garofolo, Trieste, Italy. G. Ferrara, MD, University of Trieste; S. Pastore, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; L. Sancin, MD, University of Trieste; L. Torelli, MSs, University of Trieste; O. Radillo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; M. Bramuzzo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; C. Bibalo, MD, University of Trieste; A. Tommasini, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Ventura, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Taddio, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Address correspondence to Dr. A. Taddio, MD, University of Trieste and Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34100, Trieste, Italy. E-mail: andrea.taddio@burlo.trieste.it Accepted for publication March 7, 2018.
Lucio Torelli
From the University of Trieste; Institute for Maternal and Child Health – Institute for Research and Health Care (IRCCS) Burlo Garofolo, Trieste, Italy. G. Ferrara, MD, University of Trieste; S. Pastore, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; L. Sancin, MD, University of Trieste; L. Torelli, MSs, University of Trieste; O. Radillo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; M. Bramuzzo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; C. Bibalo, MD, University of Trieste; A. Tommasini, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Ventura, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Taddio, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Address correspondence to Dr. A. Taddio, MD, University of Trieste and Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34100, Trieste, Italy. E-mail: andrea.taddio@burlo.trieste.it Accepted for publication March 7, 2018.
Oriano Radillo
From the University of Trieste; Institute for Maternal and Child Health – Institute for Research and Health Care (IRCCS) Burlo Garofolo, Trieste, Italy. G. Ferrara, MD, University of Trieste; S. Pastore, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; L. Sancin, MD, University of Trieste; L. Torelli, MSs, University of Trieste; O. Radillo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; M. Bramuzzo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; C. Bibalo, MD, University of Trieste; A. Tommasini, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Ventura, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Taddio, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Address correspondence to Dr. A. Taddio, MD, University of Trieste and Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34100, Trieste, Italy. E-mail: andrea.taddio@burlo.trieste.it Accepted for publication March 7, 2018.
Matteo Bramuzzo
From the University of Trieste; Institute for Maternal and Child Health – Institute for Research and Health Care (IRCCS) Burlo Garofolo, Trieste, Italy. G. Ferrara, MD, University of Trieste; S. Pastore, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; L. Sancin, MD, University of Trieste; L. Torelli, MSs, University of Trieste; O. Radillo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; M. Bramuzzo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; C. Bibalo, MD, University of Trieste; A. Tommasini, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Ventura, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Taddio, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Address correspondence to Dr. A. Taddio, MD, University of Trieste and Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34100, Trieste, Italy. E-mail: andrea.taddio@burlo.trieste.it Accepted for publication March 7, 2018.
Chiara Bibalo
From the University of Trieste; Institute for Maternal and Child Health – Institute for Research and Health Care (IRCCS) Burlo Garofolo, Trieste, Italy. G. Ferrara, MD, University of Trieste; S. Pastore, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; L. Sancin, MD, University of Trieste; L. Torelli, MSs, University of Trieste; O. Radillo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; M. Bramuzzo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; C. Bibalo, MD, University of Trieste; A. Tommasini, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Ventura, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Taddio, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Address correspondence to Dr. A. Taddio, MD, University of Trieste and Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34100, Trieste, Italy. E-mail: andrea.taddio@burlo.trieste.it Accepted for publication March 7, 2018.
Alberto Tommasini
From the University of Trieste; Institute for Maternal and Child Health – Institute for Research and Health Care (IRCCS) Burlo Garofolo, Trieste, Italy. G. Ferrara, MD, University of Trieste; S. Pastore, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; L. Sancin, MD, University of Trieste; L. Torelli, MSs, University of Trieste; O. Radillo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; M. Bramuzzo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; C. Bibalo, MD, University of Trieste; A. Tommasini, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Ventura, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Taddio, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Address correspondence to Dr. A. Taddio, MD, University of Trieste and Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34100, Trieste, Italy. E-mail: andrea.taddio@burlo.trieste.it Accepted for publication March 7, 2018.
Alessandro Ventura
From the University of Trieste; Institute for Maternal and Child Health – Institute for Research and Health Care (IRCCS) Burlo Garofolo, Trieste, Italy. G. Ferrara, MD, University of Trieste; S. Pastore, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; L. Sancin, MD, University of Trieste; L. Torelli, MSs, University of Trieste; O. Radillo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; M. Bramuzzo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; C. Bibalo, MD, University of Trieste; A. Tommasini, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Ventura, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Taddio, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Address correspondence to Dr. A. Taddio, MD, University of Trieste and Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34100, Trieste, Italy. E-mail: andrea.taddio@burlo.trieste.it Accepted for publication March 7, 2018.
Andrea Taddio
From the University of Trieste; Institute for Maternal and Child Health – Institute for Research and Health Care (IRCCS) Burlo Garofolo, Trieste, Italy. G. Ferrara, MD, University of Trieste; S. Pastore, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; L. Sancin, MD, University of Trieste; L. Torelli, MSs, University of Trieste; O. Radillo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; M. Bramuzzo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; C. Bibalo, MD, University of Trieste; A. Tommasini, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Ventura, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Taddio, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Address correspondence to Dr. A. Taddio, MD, University of Trieste and Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34100, Trieste, Italy. E-mail: andrea.taddio@burlo.trieste.it Accepted for publication March 7, 2018.
Abstract
Objective This study aimed to test fecal calprotectin (FC) as a screening tool to identify inflammatory bowel disease (IBD) among patients with juvenile idiopathic arthritis (JIA).
Methods FC level < 100 g/kg was considered normal. Patients with 2 consecutive FC dosage ≥ 100 g/kg underwent endoscopic evaluation.
Results There were 113 patients with JIA enrolled. FC was raised in 7 patients out of 113. All patients had IBD. In 3/7 patients, high FC levels were the only sign consistent with IBD.
Conclusion FC is a useful, economical, and noninvasive diagnostic tool to identify JIA patients with underlying IBD.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Fecal Calprotectin to Detect Inflammatory Bowel Disease in Juvenile Idiopathic Arthritis
Giovanna Ferrara, Serena Pastore, Lara Sancin, Lucio Torelli, Oriano Radillo, Matteo Bramuzzo, Chiara Bibalo, Alberto Tommasini, Alessandro Ventura, Andrea Taddio
The Journal of Rheumatology Jun 2018, jrheum.171200; DOI: 10.3899/jrheum.171200
Fecal Calprotectin to Detect Inflammatory Bowel Disease in Juvenile Idiopathic Arthritis
Giovanna Ferrara, Serena Pastore, Lara Sancin, Lucio Torelli, Oriano Radillo, Matteo Bramuzzo, Chiara Bibalo, Alberto Tommasini, Alessandro Ventura, Andrea Taddio
The Journal of Rheumatology Jun 2018, jrheum.171200; DOI: 10.3899/jrheum.171200