Flares of Disease in Children with Clinically Inactive Juvenile Idiopathic Arthritis Were Not Correlated with Ultrasound Findings

From Pediatric Rheumatology, Department of Pediatrics, the Center for Clinical and Translational Research (CCTR), and Pediatric Radiology, Seattle Children’s Hospital, University of Washington, Seattle, Washington, USA. The project described was supported by the CCTR at Seattle Children’s Hospital, the US National Center for Advancing Translational Sciences, and the US National Institutes of Health (NIH), through grant UL1 TR000002. YZ was supported by the Childhood Arthritis and Rheumatology Research Alliance (CARRA). Statistical work and the Research Electronic Data Capture database were supported by an Institute of Translational Health Sciences grant (UL1 RR025014 from the National Center for Research Resources/NIH). Y. Zhao, MD, PhD, Pediatric Rheumatology, Department of Pediatrics, and CCTR, Seattle Children’s Hospital, University of Washington; N.E. Rascoff, MD, MPH, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; R.S. Iyer, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; M. Thapa, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; L. Reichley, BA, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; A.P. Oron, PhD, Epidemiology Section, Institute for Disease Modeling, Bellevue, Washington, USA; C.A. Wallace, MD, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington. Drs. Zhao and Rascoff contributed equally to the project. Address correspondence to Dr. Y. Zhao, MA 7.110, 4800 Sand Point Way NE, Seattle, Washington 98105, USA. E-mail: yongdong.zhao{at}seattlechildrens.org. Accepted for publication December 15, 2017.

From Pediatric Rheumatology, Department of Pediatrics, the Center for Clinical and Translational Research (CCTR), and Pediatric Radiology, Seattle Children’s Hospital, University of Washington, Seattle, Washington, USA. The project described was supported by the CCTR at Seattle Children’s Hospital, the US National Center for Advancing Translational Sciences, and the US National Institutes of Health (NIH), through grant UL1 TR000002. YZ was supported by the Childhood Arthritis and Rheumatology Research Alliance (CARRA). Statistical work and the Research Electronic Data Capture database were supported by an Institute of Translational Health Sciences grant (UL1 RR025014 from the National Center for Research Resources/NIH). Y. Zhao, MD, PhD, Pediatric Rheumatology, Department of Pediatrics, and CCTR, Seattle Children’s Hospital, University of Washington; N.E. Rascoff, MD, MPH, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; R.S. Iyer, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; M. Thapa, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; L. Reichley, BA, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; A.P. Oron, PhD, Epidemiology Section, Institute for Disease Modeling, Bellevue, Washington, USA; C.A. Wallace, MD, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington. Drs. Zhao and Rascoff contributed equally to the project. Address correspondence to Dr. Y. Zhao, MA 7.110, 4800 Sand Point Way NE, Seattle, Washington 98105, USA. E-mail: yongdong.zhao{at}seattlechildrens.org. Accepted for publication December 15, 2017.

From Pediatric Rheumatology, Department of Pediatrics, the Center for Clinical and Translational Research (CCTR), and Pediatric Radiology, Seattle Children’s Hospital, University of Washington, Seattle, Washington, USA. The project described was supported by the CCTR at Seattle Children’s Hospital, the US National Center for Advancing Translational Sciences, and the US National Institutes of Health (NIH), through grant UL1 TR000002. YZ was supported by the Childhood Arthritis and Rheumatology Research Alliance (CARRA). Statistical work and the Research Electronic Data Capture database were supported by an Institute of Translational Health Sciences grant (UL1 RR025014 from the National Center for Research Resources/NIH). Y. Zhao, MD, PhD, Pediatric Rheumatology, Department of Pediatrics, and CCTR, Seattle Children’s Hospital, University of Washington; N.E. Rascoff, MD, MPH, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; R.S. Iyer, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; M. Thapa, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; L. Reichley, BA, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; A.P. Oron, PhD, Epidemiology Section, Institute for Disease Modeling, Bellevue, Washington, USA; C.A. Wallace, MD, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington. Drs. Zhao and Rascoff contributed equally to the project. Address correspondence to Dr. Y. Zhao, MA 7.110, 4800 Sand Point Way NE, Seattle, Washington 98105, USA. E-mail: yongdong.zhao{at}seattlechildrens.org. Accepted for publication December 15, 2017.

From Pediatric Rheumatology, Department of Pediatrics, the Center for Clinical and Translational Research (CCTR), and Pediatric Radiology, Seattle Children’s Hospital, University of Washington, Seattle, Washington, USA. The project described was supported by the CCTR at Seattle Children’s Hospital, the US National Center for Advancing Translational Sciences, and the US National Institutes of Health (NIH), through grant UL1 TR000002. YZ was supported by the Childhood Arthritis and Rheumatology Research Alliance (CARRA). Statistical work and the Research Electronic Data Capture database were supported by an Institute of Translational Health Sciences grant (UL1 RR025014 from the National Center for Research Resources/NIH). Y. Zhao, MD, PhD, Pediatric Rheumatology, Department of Pediatrics, and CCTR, Seattle Children’s Hospital, University of Washington; N.E. Rascoff, MD, MPH, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; R.S. Iyer, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; M. Thapa, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; L. Reichley, BA, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; A.P. Oron, PhD, Epidemiology Section, Institute for Disease Modeling, Bellevue, Washington, USA; C.A. Wallace, MD, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington. Drs. Zhao and Rascoff contributed equally to the project. Address correspondence to Dr. Y. Zhao, MA 7.110, 4800 Sand Point Way NE, Seattle, Washington 98105, USA. E-mail: yongdong.zhao{at}seattlechildrens.org. Accepted for publication December 15, 2017.

From Pediatric Rheumatology, Department of Pediatrics, the Center for Clinical and Translational Research (CCTR), and Pediatric Radiology, Seattle Children’s Hospital, University of Washington, Seattle, Washington, USA. The project described was supported by the CCTR at Seattle Children’s Hospital, the US National Center for Advancing Translational Sciences, and the US National Institutes of Health (NIH), through grant UL1 TR000002. YZ was supported by the Childhood Arthritis and Rheumatology Research Alliance (CARRA). Statistical work and the Research Electronic Data Capture database were supported by an Institute of Translational Health Sciences grant (UL1 RR025014 from the National Center for Research Resources/NIH). Y. Zhao, MD, PhD, Pediatric Rheumatology, Department of Pediatrics, and CCTR, Seattle Children’s Hospital, University of Washington; N.E. Rascoff, MD, MPH, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; R.S. Iyer, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; M. Thapa, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; L. Reichley, BA, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; A.P. Oron, PhD, Epidemiology Section, Institute for Disease Modeling, Bellevue, Washington, USA; C.A. Wallace, MD, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington. Drs. Zhao and Rascoff contributed equally to the project. Address correspondence to Dr. Y. Zhao, MA 7.110, 4800 Sand Point Way NE, Seattle, Washington 98105, USA. E-mail: yongdong.zhao{at}seattlechildrens.org. Accepted for publication December 15, 2017.

From Pediatric Rheumatology, Department of Pediatrics, the Center for Clinical and Translational Research (CCTR), and Pediatric Radiology, Seattle Children’s Hospital, University of Washington, Seattle, Washington, USA. The project described was supported by the CCTR at Seattle Children’s Hospital, the US National Center for Advancing Translational Sciences, and the US National Institutes of Health (NIH), through grant UL1 TR000002. YZ was supported by the Childhood Arthritis and Rheumatology Research Alliance (CARRA). Statistical work and the Research Electronic Data Capture database were supported by an Institute of Translational Health Sciences grant (UL1 RR025014 from the National Center for Research Resources/NIH). Y. Zhao, MD, PhD, Pediatric Rheumatology, Department of Pediatrics, and CCTR, Seattle Children’s Hospital, University of Washington; N.E. Rascoff, MD, MPH, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; R.S. Iyer, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; M. Thapa, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; L. Reichley, BA, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; A.P. Oron, PhD, Epidemiology Section, Institute for Disease Modeling, Bellevue, Washington, USA; C.A. Wallace, MD, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington. Drs. Zhao and Rascoff contributed equally to the project. Address correspondence to Dr. Y. Zhao, MA 7.110, 4800 Sand Point Way NE, Seattle, Washington 98105, USA. E-mail: yongdong.zhao{at}seattlechildrens.org. Accepted for publication December 15, 2017.

From Pediatric Rheumatology, Department of Pediatrics, the Center for Clinical and Translational Research (CCTR), and Pediatric Radiology, Seattle Children’s Hospital, University of Washington, Seattle, Washington, USA. The project described was supported by the CCTR at Seattle Children’s Hospital, the US National Center for Advancing Translational Sciences, and the US National Institutes of Health (NIH), through grant UL1 TR000002. YZ was supported by the Childhood Arthritis and Rheumatology Research Alliance (CARRA). Statistical work and the Research Electronic Data Capture database were supported by an Institute of Translational Health Sciences grant (UL1 RR025014 from the National Center for Research Resources/NIH). Y. Zhao, MD, PhD, Pediatric Rheumatology, Department of Pediatrics, and CCTR, Seattle Children’s Hospital, University of Washington; N.E. Rascoff, MD, MPH, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; R.S. Iyer, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; M. Thapa, MD, Pediatric Radiology, Seattle Children’s Hospital, University of Washington; L. Reichley, BA, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington; A.P. Oron, PhD, Epidemiology Section, Institute for Disease Modeling, Bellevue, Washington, USA; C.A. Wallace, MD, Pediatric Rheumatology, Department of Pediatrics, Seattle Children’s Hospital, University of Washington. Drs. Zhao and Rascoff contributed equally to the project. Address correspondence to Dr. Y. Zhao, MA 7.110, 4800 Sand Point Way NE, Seattle, Washington 98105, USA. E-mail: yongdong.zhao{at}seattlechildrens.org. Accepted for publication December 15, 2017.