Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on YouTube
  • Follow jrheum on Instagram
  • Follow jrheum on RSS
Research ArticleArticle

Performance of Screening Tests for Cognitive Impairment in Systemic Lupus Erythematosus

Stephanie G. Nantes, Jiandong Su, Ashneet Dhaliwal, Kenneth Colosimo and Zahi Touma
The Journal of Rheumatology September 2017, jrheum.161125; DOI: https://doi.org/10.3899/jrheum.161125
Stephanie G. Nantes
From the University of Toronto; University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; York University, Toronto, Ontario, Canada. The Toronto Lupus Clinic Research Program is supported financially by the University Health Network, the Lou Rocca family, and the Lupus Foundation of Ontario. Dr. Touma’s research is supported by the Young Operating and the Young Investigator Salary Award of the Arthritis Society, and the New Investigator Research Grant of the Physicians’ Services Inc. Foundation. S.G. Nantes, BMSc, MD Candidate, University of Toronto; J. Su, MSc, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; A. Dhaliwal, HonBSc, University of Toronto; K. Colosimo, MA, Clinical Psychology, PhD(c), York University, Psychometrist and Research Analyst, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; Z. Touma, MD, FACP, FACR, PhD, Assistant Professor of Medicine, University of Toronto Lupus Clinic, Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases. Address correspondence to Dr. Z. Touma, MD, FACP, FACR, PhD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst St., Toronto, Ontario M5T 2S8, Canada. E-mail address: zahi.touma@uhn.ca. Accepted for publication June 23, 2017.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jiandong Su
From the University of Toronto; University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; York University, Toronto, Ontario, Canada. The Toronto Lupus Clinic Research Program is supported financially by the University Health Network, the Lou Rocca family, and the Lupus Foundation of Ontario. Dr. Touma’s research is supported by the Young Operating and the Young Investigator Salary Award of the Arthritis Society, and the New Investigator Research Grant of the Physicians’ Services Inc. Foundation. S.G. Nantes, BMSc, MD Candidate, University of Toronto; J. Su, MSc, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; A. Dhaliwal, HonBSc, University of Toronto; K. Colosimo, MA, Clinical Psychology, PhD(c), York University, Psychometrist and Research Analyst, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; Z. Touma, MD, FACP, FACR, PhD, Assistant Professor of Medicine, University of Toronto Lupus Clinic, Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases. Address correspondence to Dr. Z. Touma, MD, FACP, FACR, PhD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst St., Toronto, Ontario M5T 2S8, Canada. E-mail address: zahi.touma@uhn.ca. Accepted for publication June 23, 2017.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ashneet Dhaliwal
From the University of Toronto; University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; York University, Toronto, Ontario, Canada. The Toronto Lupus Clinic Research Program is supported financially by the University Health Network, the Lou Rocca family, and the Lupus Foundation of Ontario. Dr. Touma’s research is supported by the Young Operating and the Young Investigator Salary Award of the Arthritis Society, and the New Investigator Research Grant of the Physicians’ Services Inc. Foundation. S.G. Nantes, BMSc, MD Candidate, University of Toronto; J. Su, MSc, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; A. Dhaliwal, HonBSc, University of Toronto; K. Colosimo, MA, Clinical Psychology, PhD(c), York University, Psychometrist and Research Analyst, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; Z. Touma, MD, FACP, FACR, PhD, Assistant Professor of Medicine, University of Toronto Lupus Clinic, Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases. Address correspondence to Dr. Z. Touma, MD, FACP, FACR, PhD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst St., Toronto, Ontario M5T 2S8, Canada. E-mail address: zahi.touma@uhn.ca. Accepted for publication June 23, 2017.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kenneth Colosimo
From the University of Toronto; University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; York University, Toronto, Ontario, Canada. The Toronto Lupus Clinic Research Program is supported financially by the University Health Network, the Lou Rocca family, and the Lupus Foundation of Ontario. Dr. Touma’s research is supported by the Young Operating and the Young Investigator Salary Award of the Arthritis Society, and the New Investigator Research Grant of the Physicians’ Services Inc. Foundation. S.G. Nantes, BMSc, MD Candidate, University of Toronto; J. Su, MSc, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; A. Dhaliwal, HonBSc, University of Toronto; K. Colosimo, MA, Clinical Psychology, PhD(c), York University, Psychometrist and Research Analyst, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; Z. Touma, MD, FACP, FACR, PhD, Assistant Professor of Medicine, University of Toronto Lupus Clinic, Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases. Address correspondence to Dr. Z. Touma, MD, FACP, FACR, PhD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst St., Toronto, Ontario M5T 2S8, Canada. E-mail address: zahi.touma@uhn.ca. Accepted for publication June 23, 2017.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zahi Touma
From the University of Toronto; University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; York University, Toronto, Ontario, Canada. The Toronto Lupus Clinic Research Program is supported financially by the University Health Network, the Lou Rocca family, and the Lupus Foundation of Ontario. Dr. Touma’s research is supported by the Young Operating and the Young Investigator Salary Award of the Arthritis Society, and the New Investigator Research Grant of the Physicians’ Services Inc. Foundation. S.G. Nantes, BMSc, MD Candidate, University of Toronto; J. Su, MSc, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; A. Dhaliwal, HonBSc, University of Toronto; K. Colosimo, MA, Clinical Psychology, PhD(c), York University, Psychometrist and Research Analyst, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; Z. Touma, MD, FACP, FACR, PhD, Assistant Professor of Medicine, University of Toronto Lupus Clinic, Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases. Address correspondence to Dr. Z. Touma, MD, FACP, FACR, PhD, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, EW, 1-412, 399 Bathurst St., Toronto, Ontario M5T 2S8, Canada. E-mail address: zahi.touma@uhn.ca. Accepted for publication June 23, 2017.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • References
  • PDF
  • eLetters
Next
Loading

Abstract

Objective There is a need for a cognitive function screening test that can be administered to patients with systemic lupus erythematosus (SLE) in clinic. The objectives of this study were to determine (1) prevalence of cognitive impairment (CI) in SLE by the Montreal Cognitive Assessment (MoCA), Mini Mental State Examination (MMSE), in relation to the Hopkins Verbal Learning Test–Revised (HVLT-R), and Perceived Deficits Questionnaire 5-Item (PDQ-5); and (2) associated factors with CI.

Methods Consecutive patients followed at a single center were recruited. HVLT-R, MoCA, and MMSE were administered. Sensitivity/specificity, positive (PPV)/negative (NPV) predictive values, and positive likelihood ratio (LR+) of MoCA/MMSE were determined (compared to HVLT-R). A test on intellectual ability and questionnaires on anxiety, depression, and perceived cognitive deficits were completed. Regression analyses determined associations with CI.

Results Of 98 patients, 48% had CI using MoCA and 31% using HVLT-R. Sensitivity was higher for MoCA (73%) compared to MMSE (27%), though MMSE was more specific (90%) than MoCA (63%). PPV and LR+ were similar in MoCA and MMSE (PPV: 47%, 53%; LR+: 2.0, 2.6, respectively), but NPV was higher in MoCA (84%) than MMSE (74%). PDQ-5 predicted objective CI (HVLT-R: sensitivity 100%, specificity 89%). Although CI was associated with depression in univariate analyses, it did not hold in the multivariate analysis, while longer SLE disease duration and more years of education remained significant.

Conclusion CI is highly prevalent and MoCA may be a useful tool to screen for CI in SLE. Patients with more years of education were less likely to have CI.

Next
Back to top

In this issue

The Journal of Rheumatology
Vol. 50, Issue 2
1 Feb 2023
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Performance of Screening Tests for Cognitive Impairment in Systemic Lupus Erythematosus
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Performance of Screening Tests for Cognitive Impairment in Systemic Lupus Erythematosus
Stephanie G. Nantes, Jiandong Su, Ashneet Dhaliwal, Kenneth Colosimo, Zahi Touma
The Journal of Rheumatology Sep 2017, jrheum.161125; DOI: 10.3899/jrheum.161125

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
Performance of Screening Tests for Cognitive Impairment in Systemic Lupus Erythematosus
Stephanie G. Nantes, Jiandong Su, Ashneet Dhaliwal, Kenneth Colosimo, Zahi Touma
The Journal of Rheumatology Sep 2017, jrheum.161125; DOI: 10.3899/jrheum.161125
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics
  • References
  • PDF
  • eLetters

Related Articles

Cited By...

More in this TOC Section

  • Clinimetric Validation of the Assessment of Spondyloarthritis International Society Health Index in Patients With Radiographic Axial Spondyloarthritis in Ixekizumab Trials
  • Sex-Specific Differences in Patients With Psoriatic Arthritis: A Systematic Review
  • Clustering Patients With Gout Based on Comorbidities and Biomarkers: A Cross-Sectional Study
Show more Articles

Similar Articles

Content

  • First Release
  • Current
  • Archives
  • Collections
  • Audiovisual Rheum
  • COVID-19 and Rheumatology

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • Privacy/GDPR Policy
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2022 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire