Research ArticleArticle
Open Access
Safety and Efficacy of Baricitinib Through 128 Weeks in an Open-label, Longterm Extension Study in Patients with Rheumatoid Arthritis
Edward C. Keystone, Mark C. Genovese, Douglas E. Schlichting, Inmaculada de la Torre, Scott D. Beattie, Terence P. Rooney and Peter C. Taylor
The Journal of Rheumatology August 2017, jrheum.161161; DOI: https://doi.org/10.3899/jrheum.161161
Edward C. Keystone
From the Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, California; Eli Lilly and Company, Indianapolis, Indiana, USA; Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. The study was funded by Eli Lilly and Company and Incyte Corp. ECK has received grants/research support or consulting support from Amgen, Eli Lilly and Company, Merck, Pfizer, and Sandoz. MCG has received grants/research support or consulting support from Eli Lilly and Company. DES, SDB, I. de la T, and TPR are employees of, and own stock or stock options in, Eli Lilly and Company. PCT has received grants/research support or consulting support from Eli Lilly and Company. E.C. Keystone, MD, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital; M.C. Genovese, MD, Division of Immunology and Rheumatology, Stanford University School of Medicine; D.E. Schlichting, RN, PhD, Eli Lilly and Company; I. de la Torre, MD, PhD, Eli Lilly and Company; S.D. Beattie, PhD, Eli Lilly and Company; T.P. Rooney, MD, Eli Lilly and Company; P.C. Taylor, MA, PhD, FRCP, FRCPE, Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford. Address correspondence to Dr. E.C. Keystone, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, 60 Murray St., Room 2-006, Box 4, Toronto, Ontario M5T 3L9, Canada. E-mail: Ed.Keystone@sinaihealthsystem.ca. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication June 3, 2017.
Mark C. Genovese
From the Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, California; Eli Lilly and Company, Indianapolis, Indiana, USA; Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. The study was funded by Eli Lilly and Company and Incyte Corp. ECK has received grants/research support or consulting support from Amgen, Eli Lilly and Company, Merck, Pfizer, and Sandoz. MCG has received grants/research support or consulting support from Eli Lilly and Company. DES, SDB, I. de la T, and TPR are employees of, and own stock or stock options in, Eli Lilly and Company. PCT has received grants/research support or consulting support from Eli Lilly and Company. E.C. Keystone, MD, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital; M.C. Genovese, MD, Division of Immunology and Rheumatology, Stanford University School of Medicine; D.E. Schlichting, RN, PhD, Eli Lilly and Company; I. de la Torre, MD, PhD, Eli Lilly and Company; S.D. Beattie, PhD, Eli Lilly and Company; T.P. Rooney, MD, Eli Lilly and Company; P.C. Taylor, MA, PhD, FRCP, FRCPE, Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford. Address correspondence to Dr. E.C. Keystone, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, 60 Murray St., Room 2-006, Box 4, Toronto, Ontario M5T 3L9, Canada. E-mail: Ed.Keystone@sinaihealthsystem.ca. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication June 3, 2017.
Douglas E. Schlichting
From the Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, California; Eli Lilly and Company, Indianapolis, Indiana, USA; Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. The study was funded by Eli Lilly and Company and Incyte Corp. ECK has received grants/research support or consulting support from Amgen, Eli Lilly and Company, Merck, Pfizer, and Sandoz. MCG has received grants/research support or consulting support from Eli Lilly and Company. DES, SDB, I. de la T, and TPR are employees of, and own stock or stock options in, Eli Lilly and Company. PCT has received grants/research support or consulting support from Eli Lilly and Company. E.C. Keystone, MD, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital; M.C. Genovese, MD, Division of Immunology and Rheumatology, Stanford University School of Medicine; D.E. Schlichting, RN, PhD, Eli Lilly and Company; I. de la Torre, MD, PhD, Eli Lilly and Company; S.D. Beattie, PhD, Eli Lilly and Company; T.P. Rooney, MD, Eli Lilly and Company; P.C. Taylor, MA, PhD, FRCP, FRCPE, Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford. Address correspondence to Dr. E.C. Keystone, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, 60 Murray St., Room 2-006, Box 4, Toronto, Ontario M5T 3L9, Canada. E-mail: Ed.Keystone@sinaihealthsystem.ca. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication June 3, 2017.
Inmaculada de la Torre
From the Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, California; Eli Lilly and Company, Indianapolis, Indiana, USA; Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. The study was funded by Eli Lilly and Company and Incyte Corp. ECK has received grants/research support or consulting support from Amgen, Eli Lilly and Company, Merck, Pfizer, and Sandoz. MCG has received grants/research support or consulting support from Eli Lilly and Company. DES, SDB, I. de la T, and TPR are employees of, and own stock or stock options in, Eli Lilly and Company. PCT has received grants/research support or consulting support from Eli Lilly and Company. E.C. Keystone, MD, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital; M.C. Genovese, MD, Division of Immunology and Rheumatology, Stanford University School of Medicine; D.E. Schlichting, RN, PhD, Eli Lilly and Company; I. de la Torre, MD, PhD, Eli Lilly and Company; S.D. Beattie, PhD, Eli Lilly and Company; T.P. Rooney, MD, Eli Lilly and Company; P.C. Taylor, MA, PhD, FRCP, FRCPE, Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford. Address correspondence to Dr. E.C. Keystone, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, 60 Murray St., Room 2-006, Box 4, Toronto, Ontario M5T 3L9, Canada. E-mail: Ed.Keystone@sinaihealthsystem.ca. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication June 3, 2017.
Scott D. Beattie
From the Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, California; Eli Lilly and Company, Indianapolis, Indiana, USA; Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. The study was funded by Eli Lilly and Company and Incyte Corp. ECK has received grants/research support or consulting support from Amgen, Eli Lilly and Company, Merck, Pfizer, and Sandoz. MCG has received grants/research support or consulting support from Eli Lilly and Company. DES, SDB, I. de la T, and TPR are employees of, and own stock or stock options in, Eli Lilly and Company. PCT has received grants/research support or consulting support from Eli Lilly and Company. E.C. Keystone, MD, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital; M.C. Genovese, MD, Division of Immunology and Rheumatology, Stanford University School of Medicine; D.E. Schlichting, RN, PhD, Eli Lilly and Company; I. de la Torre, MD, PhD, Eli Lilly and Company; S.D. Beattie, PhD, Eli Lilly and Company; T.P. Rooney, MD, Eli Lilly and Company; P.C. Taylor, MA, PhD, FRCP, FRCPE, Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford. Address correspondence to Dr. E.C. Keystone, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, 60 Murray St., Room 2-006, Box 4, Toronto, Ontario M5T 3L9, Canada. E-mail: Ed.Keystone@sinaihealthsystem.ca. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication June 3, 2017.
Terence P. Rooney
From the Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, California; Eli Lilly and Company, Indianapolis, Indiana, USA; Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. The study was funded by Eli Lilly and Company and Incyte Corp. ECK has received grants/research support or consulting support from Amgen, Eli Lilly and Company, Merck, Pfizer, and Sandoz. MCG has received grants/research support or consulting support from Eli Lilly and Company. DES, SDB, I. de la T, and TPR are employees of, and own stock or stock options in, Eli Lilly and Company. PCT has received grants/research support or consulting support from Eli Lilly and Company. E.C. Keystone, MD, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital; M.C. Genovese, MD, Division of Immunology and Rheumatology, Stanford University School of Medicine; D.E. Schlichting, RN, PhD, Eli Lilly and Company; I. de la Torre, MD, PhD, Eli Lilly and Company; S.D. Beattie, PhD, Eli Lilly and Company; T.P. Rooney, MD, Eli Lilly and Company; P.C. Taylor, MA, PhD, FRCP, FRCPE, Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford. Address correspondence to Dr. E.C. Keystone, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, 60 Murray St., Room 2-006, Box 4, Toronto, Ontario M5T 3L9, Canada. E-mail: Ed.Keystone@sinaihealthsystem.ca. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication June 3, 2017.
Peter C. Taylor
From the Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, California; Eli Lilly and Company, Indianapolis, Indiana, USA; Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. The study was funded by Eli Lilly and Company and Incyte Corp. ECK has received grants/research support or consulting support from Amgen, Eli Lilly and Company, Merck, Pfizer, and Sandoz. MCG has received grants/research support or consulting support from Eli Lilly and Company. DES, SDB, I. de la T, and TPR are employees of, and own stock or stock options in, Eli Lilly and Company. PCT has received grants/research support or consulting support from Eli Lilly and Company. E.C. Keystone, MD, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital; M.C. Genovese, MD, Division of Immunology and Rheumatology, Stanford University School of Medicine; D.E. Schlichting, RN, PhD, Eli Lilly and Company; I. de la Torre, MD, PhD, Eli Lilly and Company; S.D. Beattie, PhD, Eli Lilly and Company; T.P. Rooney, MD, Eli Lilly and Company; P.C. Taylor, MA, PhD, FRCP, FRCPE, Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford. Address correspondence to Dr. E.C. Keystone, The Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, 60 Murray St., Room 2-006, Box 4, Toronto, Ontario M5T 3L9, Canada. E-mail: Ed.Keystone@sinaihealthsystem.ca. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication June 3, 2017.
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The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Safety and Efficacy of Baricitinib Through 128 Weeks in an Open-label, Longterm Extension Study in Patients with Rheumatoid Arthritis
Edward C. Keystone, Mark C. Genovese, Douglas E. Schlichting, Inmaculada de la Torre, Scott D. Beattie, Terence P. Rooney, Peter C. Taylor
The Journal of Rheumatology Aug 2017, jrheum.161161; DOI: 10.3899/jrheum.161161
Safety and Efficacy of Baricitinib Through 128 Weeks in an Open-label, Longterm Extension Study in Patients with Rheumatoid Arthritis
Edward C. Keystone, Mark C. Genovese, Douglas E. Schlichting, Inmaculada de la Torre, Scott D. Beattie, Terence P. Rooney, Peter C. Taylor
The Journal of Rheumatology Aug 2017, jrheum.161161; DOI: 10.3899/jrheum.161161