Research ArticleArticle
Anti-carbamylated Protein Antibodies Are Detectable in Various Connective Tissue Diseases
Shuichiro Nakabo, Hajime Yoshifuji, Motomu Hashimoto, Yoshitaka Imura, Ran Nakashima, Kosaku Murakami, Nobuo Kuramoto, Shinji Ito, Junko Satoh, Masao Tanaka, Takao Fujii, Tsuneyo Mimori and Koichiro Ohmura
The Journal of Rheumatology May 2017, jrheum.161432; DOI: https://doi.org/10.3899/jrheum.161432
Shuichiro Nakabo
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan. S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University. Address correspondence to Dr. K. Ohmura, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. E-mail: ohmurako@kuhp.kyoto-u.ac.jp. Accepted for publication April 5, 2017.
Hajime Yoshifuji
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan. S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University. Address correspondence to Dr. K. Ohmura, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. E-mail: ohmurako@kuhp.kyoto-u.ac.jp. Accepted for publication April 5, 2017.
Motomu Hashimoto
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan. S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University. Address correspondence to Dr. K. Ohmura, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. E-mail: ohmurako@kuhp.kyoto-u.ac.jp. Accepted for publication April 5, 2017.
Yoshitaka Imura
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan. S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University. Address correspondence to Dr. K. Ohmura, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. E-mail: ohmurako@kuhp.kyoto-u.ac.jp. Accepted for publication April 5, 2017.
Ran Nakashima
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan. S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University. Address correspondence to Dr. K. Ohmura, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. E-mail: ohmurako@kuhp.kyoto-u.ac.jp. Accepted for publication April 5, 2017.
Kosaku Murakami
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan. S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University. Address correspondence to Dr. K. Ohmura, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. E-mail: ohmurako@kuhp.kyoto-u.ac.jp. Accepted for publication April 5, 2017.
Nobuo Kuramoto
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan. S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University. Address correspondence to Dr. K. Ohmura, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. E-mail: ohmurako@kuhp.kyoto-u.ac.jp. Accepted for publication April 5, 2017.
Shinji Ito
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan. S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University. Address correspondence to Dr. K. Ohmura, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. E-mail: ohmurako@kuhp.kyoto-u.ac.jp. Accepted for publication April 5, 2017.
Junko Satoh
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan. S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University. Address correspondence to Dr. K. Ohmura, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. E-mail: ohmurako@kuhp.kyoto-u.ac.jp. Accepted for publication April 5, 2017.
Masao Tanaka
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan. S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University. Address correspondence to Dr. K. Ohmura, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. E-mail: ohmurako@kuhp.kyoto-u.ac.jp. Accepted for publication April 5, 2017.
Takao Fujii
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan. S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University. Address correspondence to Dr. K. Ohmura, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. E-mail: ohmurako@kuhp.kyoto-u.ac.jp. Accepted for publication April 5, 2017.
Tsuneyo Mimori
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan. S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University. Address correspondence to Dr. K. Ohmura, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. E-mail: ohmurako@kuhp.kyoto-u.ac.jp. Accepted for publication April 5, 2017.
Koichiro Ohmura
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan. S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University. Address correspondence to Dr. K. Ohmura, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan. E-mail: ohmurako@kuhp.kyoto-u.ac.jp. Accepted for publication April 5, 2017.
Abstract
Objective Anti-carbamylated protein (anti-CarP) antibodies are possible diagnostic biomarkers of anticitrullinated protein antibody (ACPA)-negative rheumatoid arthritis (RA). We aimed to elucidate the prevalence of anti-CarP antibodies in non-RA connective tissue diseases (CTD) because CTD are important in the differential diagnosis of ACPA-negative RA.
Methods The sera from 266 patients with RA and 616 patients with CTD and 80 healthy controls were examined using an in-house anti-CarP ELISA.
Results The prevalence and the level of anti-CarP antibodies in several CTD were comparable to those in ACPA-negative RA.
Conclusion Anti-CarP antibodies are not useful for differentiating ACPA-negative RA from CTD.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Anti-carbamylated Protein Antibodies Are Detectable in Various Connective Tissue Diseases
Shuichiro Nakabo, Hajime Yoshifuji, Motomu Hashimoto, Yoshitaka Imura, Ran Nakashima, Kosaku Murakami, Nobuo Kuramoto, Shinji Ito, Junko Satoh, Masao Tanaka, Takao Fujii, Tsuneyo Mimori, Koichiro Ohmura
The Journal of Rheumatology May 2017, jrheum.161432; DOI: 10.3899/jrheum.161432
Anti-carbamylated Protein Antibodies Are Detectable in Various Connective Tissue Diseases
Shuichiro Nakabo, Hajime Yoshifuji, Motomu Hashimoto, Yoshitaka Imura, Ran Nakashima, Kosaku Murakami, Nobuo Kuramoto, Shinji Ito, Junko Satoh, Masao Tanaka, Takao Fujii, Tsuneyo Mimori, Koichiro Ohmura
The Journal of Rheumatology May 2017, jrheum.161432; DOI: 10.3899/jrheum.161432