Research ArticleArticle
Why Do Patients with Chronic Inflammatory Rheumatic Diseases Discontinue Their Biologics? An Assessment of Patients' Adherence Using a Self-report Questionnaire
Anne-Laure Betegnie, Aurélie Gauchet, Audrey Lehmann, Laurent Grange, Matthieu Roustit, Magalie Baudrant, Pierrick Bedouch and Benoît Allenet
The Journal of Rheumatology February 2016, jrheum.150414; DOI: https://doi.org/10.3899/jrheum.150414
Anne-Laure Betegnie
From the Pharmacy Department, University Hospital; Interuniversity Laboratory of Psychology: Personality, Cognition, Social Change (LIP/PC2S), University Grenoble-Alpes; Rheumatology Clinic, and Clinical Research Center, Grenoble University Hospital; University Grenoble-Alpes/Centre National de la Recherche Scientifique (CNRS)/ Techniques de l’Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble Unité Mixte de Recherche CNRS #5525 (TIMC-IMAG UMR 5525)/Themas, Grenoble, France. Funded by a grant from the French Society of Rheumatology. A.L. Betegnie, PharmD, Pharmacy Department, University Hospital; A. Gauchet, MS, PhD, LIP/PC2S, University Grenoble-Alpes; A. Lehmann, PharmD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; L. Grange, MD, PhD, Rheumatology Clinic, Grenoble University Hospital; M. Roustit, PharmD, PhD, Clinical Research Center, Grenoble University Hospital; M. Baudrant, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; P. Bedouch, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMCIMAG UMR 5525/Themas; B. Allenet, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble- Alpes/CNRS/TIMC-IMAG UMR 5525/Themas. Address correspondence to B. Allenet, Centre Hospitalier Universitaire de Grenoble, Service Pharmacie, CS 10217, 38043 Grenoble, France. Email: BAllenet@chu-grenoble.fr. Accepted for publication January 6, 2016.
Aurélie Gauchet
From the Pharmacy Department, University Hospital; Interuniversity Laboratory of Psychology: Personality, Cognition, Social Change (LIP/PC2S), University Grenoble-Alpes; Rheumatology Clinic, and Clinical Research Center, Grenoble University Hospital; University Grenoble-Alpes/Centre National de la Recherche Scientifique (CNRS)/ Techniques de l’Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble Unité Mixte de Recherche CNRS #5525 (TIMC-IMAG UMR 5525)/Themas, Grenoble, France. Funded by a grant from the French Society of Rheumatology. A.L. Betegnie, PharmD, Pharmacy Department, University Hospital; A. Gauchet, MS, PhD, LIP/PC2S, University Grenoble-Alpes; A. Lehmann, PharmD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; L. Grange, MD, PhD, Rheumatology Clinic, Grenoble University Hospital; M. Roustit, PharmD, PhD, Clinical Research Center, Grenoble University Hospital; M. Baudrant, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; P. Bedouch, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMCIMAG UMR 5525/Themas; B. Allenet, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble- Alpes/CNRS/TIMC-IMAG UMR 5525/Themas. Address correspondence to B. Allenet, Centre Hospitalier Universitaire de Grenoble, Service Pharmacie, CS 10217, 38043 Grenoble, France. Email: BAllenet@chu-grenoble.fr. Accepted for publication January 6, 2016.
Audrey Lehmann
From the Pharmacy Department, University Hospital; Interuniversity Laboratory of Psychology: Personality, Cognition, Social Change (LIP/PC2S), University Grenoble-Alpes; Rheumatology Clinic, and Clinical Research Center, Grenoble University Hospital; University Grenoble-Alpes/Centre National de la Recherche Scientifique (CNRS)/ Techniques de l’Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble Unité Mixte de Recherche CNRS #5525 (TIMC-IMAG UMR 5525)/Themas, Grenoble, France. Funded by a grant from the French Society of Rheumatology. A.L. Betegnie, PharmD, Pharmacy Department, University Hospital; A. Gauchet, MS, PhD, LIP/PC2S, University Grenoble-Alpes; A. Lehmann, PharmD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; L. Grange, MD, PhD, Rheumatology Clinic, Grenoble University Hospital; M. Roustit, PharmD, PhD, Clinical Research Center, Grenoble University Hospital; M. Baudrant, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; P. Bedouch, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMCIMAG UMR 5525/Themas; B. Allenet, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble- Alpes/CNRS/TIMC-IMAG UMR 5525/Themas. Address correspondence to B. Allenet, Centre Hospitalier Universitaire de Grenoble, Service Pharmacie, CS 10217, 38043 Grenoble, France. Email: BAllenet@chu-grenoble.fr. Accepted for publication January 6, 2016.
Laurent Grange
From the Pharmacy Department, University Hospital; Interuniversity Laboratory of Psychology: Personality, Cognition, Social Change (LIP/PC2S), University Grenoble-Alpes; Rheumatology Clinic, and Clinical Research Center, Grenoble University Hospital; University Grenoble-Alpes/Centre National de la Recherche Scientifique (CNRS)/ Techniques de l’Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble Unité Mixte de Recherche CNRS #5525 (TIMC-IMAG UMR 5525)/Themas, Grenoble, France. Funded by a grant from the French Society of Rheumatology. A.L. Betegnie, PharmD, Pharmacy Department, University Hospital; A. Gauchet, MS, PhD, LIP/PC2S, University Grenoble-Alpes; A. Lehmann, PharmD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; L. Grange, MD, PhD, Rheumatology Clinic, Grenoble University Hospital; M. Roustit, PharmD, PhD, Clinical Research Center, Grenoble University Hospital; M. Baudrant, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; P. Bedouch, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMCIMAG UMR 5525/Themas; B. Allenet, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble- Alpes/CNRS/TIMC-IMAG UMR 5525/Themas. Address correspondence to B. Allenet, Centre Hospitalier Universitaire de Grenoble, Service Pharmacie, CS 10217, 38043 Grenoble, France. Email: BAllenet@chu-grenoble.fr. Accepted for publication January 6, 2016.
Matthieu Roustit
From the Pharmacy Department, University Hospital; Interuniversity Laboratory of Psychology: Personality, Cognition, Social Change (LIP/PC2S), University Grenoble-Alpes; Rheumatology Clinic, and Clinical Research Center, Grenoble University Hospital; University Grenoble-Alpes/Centre National de la Recherche Scientifique (CNRS)/ Techniques de l’Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble Unité Mixte de Recherche CNRS #5525 (TIMC-IMAG UMR 5525)/Themas, Grenoble, France. Funded by a grant from the French Society of Rheumatology. A.L. Betegnie, PharmD, Pharmacy Department, University Hospital; A. Gauchet, MS, PhD, LIP/PC2S, University Grenoble-Alpes; A. Lehmann, PharmD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; L. Grange, MD, PhD, Rheumatology Clinic, Grenoble University Hospital; M. Roustit, PharmD, PhD, Clinical Research Center, Grenoble University Hospital; M. Baudrant, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; P. Bedouch, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMCIMAG UMR 5525/Themas; B. Allenet, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble- Alpes/CNRS/TIMC-IMAG UMR 5525/Themas. Address correspondence to B. Allenet, Centre Hospitalier Universitaire de Grenoble, Service Pharmacie, CS 10217, 38043 Grenoble, France. Email: BAllenet@chu-grenoble.fr. Accepted for publication January 6, 2016.
Magalie Baudrant
From the Pharmacy Department, University Hospital; Interuniversity Laboratory of Psychology: Personality, Cognition, Social Change (LIP/PC2S), University Grenoble-Alpes; Rheumatology Clinic, and Clinical Research Center, Grenoble University Hospital; University Grenoble-Alpes/Centre National de la Recherche Scientifique (CNRS)/ Techniques de l’Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble Unité Mixte de Recherche CNRS #5525 (TIMC-IMAG UMR 5525)/Themas, Grenoble, France. Funded by a grant from the French Society of Rheumatology. A.L. Betegnie, PharmD, Pharmacy Department, University Hospital; A. Gauchet, MS, PhD, LIP/PC2S, University Grenoble-Alpes; A. Lehmann, PharmD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; L. Grange, MD, PhD, Rheumatology Clinic, Grenoble University Hospital; M. Roustit, PharmD, PhD, Clinical Research Center, Grenoble University Hospital; M. Baudrant, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; P. Bedouch, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMCIMAG UMR 5525/Themas; B. Allenet, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble- Alpes/CNRS/TIMC-IMAG UMR 5525/Themas. Address correspondence to B. Allenet, Centre Hospitalier Universitaire de Grenoble, Service Pharmacie, CS 10217, 38043 Grenoble, France. Email: BAllenet@chu-grenoble.fr. Accepted for publication January 6, 2016.
Pierrick Bedouch
From the Pharmacy Department, University Hospital; Interuniversity Laboratory of Psychology: Personality, Cognition, Social Change (LIP/PC2S), University Grenoble-Alpes; Rheumatology Clinic, and Clinical Research Center, Grenoble University Hospital; University Grenoble-Alpes/Centre National de la Recherche Scientifique (CNRS)/ Techniques de l’Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble Unité Mixte de Recherche CNRS #5525 (TIMC-IMAG UMR 5525)/Themas, Grenoble, France. Funded by a grant from the French Society of Rheumatology. A.L. Betegnie, PharmD, Pharmacy Department, University Hospital; A. Gauchet, MS, PhD, LIP/PC2S, University Grenoble-Alpes; A. Lehmann, PharmD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; L. Grange, MD, PhD, Rheumatology Clinic, Grenoble University Hospital; M. Roustit, PharmD, PhD, Clinical Research Center, Grenoble University Hospital; M. Baudrant, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; P. Bedouch, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMCIMAG UMR 5525/Themas; B. Allenet, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble- Alpes/CNRS/TIMC-IMAG UMR 5525/Themas. Address correspondence to B. Allenet, Centre Hospitalier Universitaire de Grenoble, Service Pharmacie, CS 10217, 38043 Grenoble, France. Email: BAllenet@chu-grenoble.fr. Accepted for publication January 6, 2016.
Benoît Allenet
From the Pharmacy Department, University Hospital; Interuniversity Laboratory of Psychology: Personality, Cognition, Social Change (LIP/PC2S), University Grenoble-Alpes; Rheumatology Clinic, and Clinical Research Center, Grenoble University Hospital; University Grenoble-Alpes/Centre National de la Recherche Scientifique (CNRS)/ Techniques de l’Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble Unité Mixte de Recherche CNRS #5525 (TIMC-IMAG UMR 5525)/Themas, Grenoble, France. Funded by a grant from the French Society of Rheumatology. A.L. Betegnie, PharmD, Pharmacy Department, University Hospital; A. Gauchet, MS, PhD, LIP/PC2S, University Grenoble-Alpes; A. Lehmann, PharmD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; L. Grange, MD, PhD, Rheumatology Clinic, Grenoble University Hospital; M. Roustit, PharmD, PhD, Clinical Research Center, Grenoble University Hospital; M. Baudrant, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; P. Bedouch, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMCIMAG UMR 5525/Themas; B. Allenet, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble- Alpes/CNRS/TIMC-IMAG UMR 5525/Themas. Address correspondence to B. Allenet, Centre Hospitalier Universitaire de Grenoble, Service Pharmacie, CS 10217, 38043 Grenoble, France. Email: BAllenet@chu-grenoble.fr. Accepted for publication January 6, 2016.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Why Do Patients with Chronic Inflammatory Rheumatic Diseases Discontinue Their Biologics? An Assessment of Patients' Adherence Using a Self-report Questionnaire
Anne-Laure Betegnie, Aurélie Gauchet, Audrey Lehmann, Laurent Grange, Matthieu Roustit, Magalie Baudrant, Pierrick Bedouch, Benoît Allenet
The Journal of Rheumatology Feb 2016, jrheum.150414; DOI: 10.3899/jrheum.150414
Why Do Patients with Chronic Inflammatory Rheumatic Diseases Discontinue Their Biologics? An Assessment of Patients' Adherence Using a Self-report Questionnaire
Anne-Laure Betegnie, Aurélie Gauchet, Audrey Lehmann, Laurent Grange, Matthieu Roustit, Magalie Baudrant, Pierrick Bedouch, Benoît Allenet
The Journal of Rheumatology Feb 2016, jrheum.150414; DOI: 10.3899/jrheum.150414