Research ArticleArticle
Ultrasound as an Outcome Measure in Gout. A Validation Process by the OMERACT Ultrasound Working Group
Lene Terslev, Marwin Gutierrez, Wolfgang A. Schmidt, Helen I. Keen, Emilio Filippucci, David Kane, Ralf Thiele, Gurjit Kaeley, Peter Balint, Peter Mandl, Andrea Delle Sedie, Hilde Berner Hammer, Robin Christensen, Ingrid Möller, Carlos Pineda, Eugene Kissin, George A. Bruyn, Annamaria Iagnocco, Esperanza Naredo and Maria Antonietta D’Agostino on behalf of OMERACT Ultrasound Working Group
The Journal of Rheumatology September 2015, jrheum.141294; DOI: https://doi.org/10.3899/jrheum.141294
Lene Terslev
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Marwin Gutierrez
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Wolfgang A. Schmidt
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Helen I. Keen
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Emilio Filippucci
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
David Kane
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Ralf Thiele
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Gurjit Kaeley
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Peter Balint
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Peter Mandl
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Andrea Delle Sedie
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Hilde Berner Hammer
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Robin Christensen
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Ingrid Möller
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Carlos Pineda
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Eugene Kissin
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
George A. Bruyn
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Annamaria Iagnocco
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Esperanza Naredo
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Maria Antonietta D’Agostino
From the Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Copenhagen, Denmark; Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy; Medical Centre for Rheumatology, Immanuel Krankenhaus, Berlin, Germany; Department of Rheumatology, Royal Perth Hospital, Perth, Australia; Department of Rheumatology, Trinity College, Dublin, Ireland; Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester, Rochester, NY, USA; College of Medicine, University of Florida, Jacksonville, FL, USA; National Institute of Rheumatology and Physiotherapy, Budapest, Hungary; Medical University of Vienna, Vienna, Austria; U.O. Reumatologia, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital, The Capital Region of Copenhagen, Denmark; Instituto Poal de Reumatologia, Barcelona, Spain; Instituto Nacional de Rehabilitacion, Mexico City, Mexico; Boston University Medical Center, Boston, MA, USA; Department of Rheumatology, MC Groep Hospitals, Lelystad, the Netherlands; Rheumatology Unit, Sapienza Università di Roma, Rome, Italy; Hospital GU Gregorio Marañón and Universidad Complutense, Madrid, Spain; APHP, Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France. Dr. Christensen is supported and acknowledges unrestricted grants from the Oak Foundation. Dr. Terslev is supported by the Danish Rheumatism Association. L. Terslev, MD, PhD, Centre for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; M. Gutierrez, MD, Clinica Reumatologica, Università Politecnica delle Marche; W.A. Schmidt, MD, PhD, Medical Centre for Rheumatology, Immanuel Krankenhaus; H.I. Keen, MD, Department of Rheumatology, Royal Perth Hospital; E. Filippucci, Clinica Reumatologica, Università Politecnica delle Marche; D. Kane, MD, PhD, Department of Rheumatology, Trinity College; R. Thiele, MD, PhD, Department of Medicine, Allergy/Immunology and Rheumatology Division, University of Rochester; G. Kaeley, MD, College of Medicine, University of Florida; P. Balint, MD, PhD, National Institute of Rheumatology and Physiotherapy; P. Mandl, MD, PhD, Medical University of Vienna; A. Delle Sedie, MD, U.O. Reumatologia, AOUP; H.B. Hammer, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; R. Christensen, PhD, The Parker Institute, Department of Rheumatology, Bispebjerg and Frederiksberg Hospital; E. Naredo, MD, Hospital GU Gregorio Marañón and Universidad Complutense; I. Möller, MD, Instituto Poal de Reumatologia; C. Pineda, MD, Instituto Nacional de Rehabilitacion; E. Kissin, MD, Boston University Medical Center; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, Rheumatology Unit, Sapienza Università di Roma; M-A. D’Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department; INSERM U1173, Laboratoire d’Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University. Address correspondence to Prof. D’Agostino, Rheumatology Department, Ambroise Paré Hospital, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: maria-antonietta.dagostino@apr.aphp.fr
Abstract
Objective To summarize the work performed by the Outcome Measures in Rheumatology (OMERACT) Ultrasound (US) Working Group on the validation of US as a potential outcome measure in gout.
Methods Based on the lack of definitions, highlighted in a recent literature review on US as an outcome tool in gout, a series of iterative exercises were carried out to obtain consensus-based definitions on US elementary components in gout using a Delphi exercise and subsequently testing these definitions in static images and in patients with proven gout. Cohen’s κ was used to test agreement, and values of 0–0.20 were considered poor, 0.20–0.40 fair, 0.40–0.60 moderate, 0.60–0.80 good, and 0.80–1 excellent.
Results With an agreement of > 80%, consensus-based definitions were obtained for the 4 elementary lesions highlighted in the literature review: tophi, aggregates, erosions, and double contour (DC). In static images interobserver reliability ranged from moderate to almost perfect, and similar results were found for the intrareader reliability. In patients the intraobserver agreement was good for all lesions except DC (moderate). The interobserver agreement was poor for aggregates and DC but moderate for the other components.
Conclusion These first steps in evaluating the validity of US as an outcome measure for gout show that the reliability of the definitions ranged from moderate to excellent in static images and somewhat lower in patients, indicating that a standardized scanning technique may be needed, before testing the responsiveness of those definitions in a composite US score.
In this issue
The Journal of Rheumatology
Vol. 52, Issue 5
1 May 2025
Ultrasound as an Outcome Measure in Gout. A Validation Process by the OMERACT Ultrasound Working Group
Lene Terslev, Marwin Gutierrez, Wolfgang A. Schmidt, Helen I. Keen, Emilio Filippucci, David Kane, Ralf Thiele, Gurjit Kaeley, Peter Balint, Peter Mandl, Andrea Delle Sedie, Hilde Berner Hammer, Robin Christensen, Ingrid Möller, Carlos Pineda, Eugene Kissin, George A. Bruyn, Annamaria Iagnocco, Esperanza Naredo, Maria Antonietta D’Agostino
The Journal of Rheumatology Sep 2015, jrheum.141294; DOI: 10.3899/jrheum.141294
Ultrasound as an Outcome Measure in Gout. A Validation Process by the OMERACT Ultrasound Working Group
Lene Terslev, Marwin Gutierrez, Wolfgang A. Schmidt, Helen I. Keen, Emilio Filippucci, David Kane, Ralf Thiele, Gurjit Kaeley, Peter Balint, Peter Mandl, Andrea Delle Sedie, Hilde Berner Hammer, Robin Christensen, Ingrid Möller, Carlos Pineda, Eugene Kissin, George A. Bruyn, Annamaria Iagnocco, Esperanza Naredo, Maria Antonietta D’Agostino
The Journal of Rheumatology Sep 2015, jrheum.141294; DOI: 10.3899/jrheum.141294
