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Research ArticleArticle

Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis

Chao Zeng, Jie Wei, Hui Li, Tuo Yang, Fang-Jie Zhang, Ding Pan, Yong-Bing Xiao, Tu-Bao Yang and Guang-Hua Lei
The Journal of Rheumatology June 2015, jrheum.141414; DOI: https://doi.org/10.3899/jrheum.141414
Chao Zeng
From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China. Supported by the Hunan Provincial Innovation Foundation For Postgraduate (CX2014A005), the Fundamental Research Funds for the Central Universities of Central South University, the National Natural Science Foundation of China (NO. 81201420, 81272034, 81472130), the Provincial Science Foundation of Hunan (NO. 14JJ3032), the Scientific Research Project of the Development and Reform Commission of Hunan Province ([2013]1199), the Scientific Research Project of Science and Technology Office of Hunan Province (2013SK2018), the Doctoral Scientific Fund Project of the Ministry of Education of China (20120162110036). C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University. Address correspondence to Dr. G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, Hunan, China, 410008. E-mail: lgh9640@sina.cn Accepted for publication March 24, 2015.
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Jie Wei
From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China. Supported by the Hunan Provincial Innovation Foundation For Postgraduate (CX2014A005), the Fundamental Research Funds for the Central Universities of Central South University, the National Natural Science Foundation of China (NO. 81201420, 81272034, 81472130), the Provincial Science Foundation of Hunan (NO. 14JJ3032), the Scientific Research Project of the Development and Reform Commission of Hunan Province ([2013]1199), the Scientific Research Project of Science and Technology Office of Hunan Province (2013SK2018), the Doctoral Scientific Fund Project of the Ministry of Education of China (20120162110036). C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University. Address correspondence to Dr. G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, Hunan, China, 410008. E-mail: lgh9640@sina.cn Accepted for publication March 24, 2015.
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Hui Li
From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China. Supported by the Hunan Provincial Innovation Foundation For Postgraduate (CX2014A005), the Fundamental Research Funds for the Central Universities of Central South University, the National Natural Science Foundation of China (NO. 81201420, 81272034, 81472130), the Provincial Science Foundation of Hunan (NO. 14JJ3032), the Scientific Research Project of the Development and Reform Commission of Hunan Province ([2013]1199), the Scientific Research Project of Science and Technology Office of Hunan Province (2013SK2018), the Doctoral Scientific Fund Project of the Ministry of Education of China (20120162110036). C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University. Address correspondence to Dr. G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, Hunan, China, 410008. E-mail: lgh9640@sina.cn Accepted for publication March 24, 2015.
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Tuo Yang
From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China. Supported by the Hunan Provincial Innovation Foundation For Postgraduate (CX2014A005), the Fundamental Research Funds for the Central Universities of Central South University, the National Natural Science Foundation of China (NO. 81201420, 81272034, 81472130), the Provincial Science Foundation of Hunan (NO. 14JJ3032), the Scientific Research Project of the Development and Reform Commission of Hunan Province ([2013]1199), the Scientific Research Project of Science and Technology Office of Hunan Province (2013SK2018), the Doctoral Scientific Fund Project of the Ministry of Education of China (20120162110036). C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University. Address correspondence to Dr. G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, Hunan, China, 410008. E-mail: lgh9640@sina.cn Accepted for publication March 24, 2015.
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Fang-Jie Zhang
From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China. Supported by the Hunan Provincial Innovation Foundation For Postgraduate (CX2014A005), the Fundamental Research Funds for the Central Universities of Central South University, the National Natural Science Foundation of China (NO. 81201420, 81272034, 81472130), the Provincial Science Foundation of Hunan (NO. 14JJ3032), the Scientific Research Project of the Development and Reform Commission of Hunan Province ([2013]1199), the Scientific Research Project of Science and Technology Office of Hunan Province (2013SK2018), the Doctoral Scientific Fund Project of the Ministry of Education of China (20120162110036). C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University. Address correspondence to Dr. G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, Hunan, China, 410008. E-mail: lgh9640@sina.cn Accepted for publication March 24, 2015.
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Ding Pan
From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China. Supported by the Hunan Provincial Innovation Foundation For Postgraduate (CX2014A005), the Fundamental Research Funds for the Central Universities of Central South University, the National Natural Science Foundation of China (NO. 81201420, 81272034, 81472130), the Provincial Science Foundation of Hunan (NO. 14JJ3032), the Scientific Research Project of the Development and Reform Commission of Hunan Province ([2013]1199), the Scientific Research Project of Science and Technology Office of Hunan Province (2013SK2018), the Doctoral Scientific Fund Project of the Ministry of Education of China (20120162110036). C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University. Address correspondence to Dr. G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, Hunan, China, 410008. E-mail: lgh9640@sina.cn Accepted for publication March 24, 2015.
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Yong-Bing Xiao
From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China. Supported by the Hunan Provincial Innovation Foundation For Postgraduate (CX2014A005), the Fundamental Research Funds for the Central Universities of Central South University, the National Natural Science Foundation of China (NO. 81201420, 81272034, 81472130), the Provincial Science Foundation of Hunan (NO. 14JJ3032), the Scientific Research Project of the Development and Reform Commission of Hunan Province ([2013]1199), the Scientific Research Project of Science and Technology Office of Hunan Province (2013SK2018), the Doctoral Scientific Fund Project of the Ministry of Education of China (20120162110036). C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University. Address correspondence to Dr. G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, Hunan, China, 410008. E-mail: lgh9640@sina.cn Accepted for publication March 24, 2015.
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Tu-Bao Yang
From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China. Supported by the Hunan Provincial Innovation Foundation For Postgraduate (CX2014A005), the Fundamental Research Funds for the Central Universities of Central South University, the National Natural Science Foundation of China (NO. 81201420, 81272034, 81472130), the Provincial Science Foundation of Hunan (NO. 14JJ3032), the Scientific Research Project of the Development and Reform Commission of Hunan Province ([2013]1199), the Scientific Research Project of Science and Technology Office of Hunan Province (2013SK2018), the Doctoral Scientific Fund Project of the Ministry of Education of China (20120162110036). C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University. Address correspondence to Dr. G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, Hunan, China, 410008. E-mail: lgh9640@sina.cn Accepted for publication March 24, 2015.
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Guang-Hua Lei
From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China. Supported by the Hunan Provincial Innovation Foundation For Postgraduate (CX2014A005), the Fundamental Research Funds for the Central Universities of Central South University, the National Natural Science Foundation of China (NO. 81201420, 81272034, 81472130), the Provincial Science Foundation of Hunan (NO. 14JJ3032), the Scientific Research Project of the Development and Reform Commission of Hunan Province ([2013]1199), the Scientific Research Project of Science and Technology Office of Hunan Province (2013SK2018), the Doctoral Scientific Fund Project of the Ministry of Education of China (20120162110036). C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University. Address correspondence to Dr. G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, Hunan, China, 410008. E-mail: lgh9640@sina.cn Accepted for publication March 24, 2015.
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Abstract

Objective To establish whether there is a relationship between serum magnesium (Mg) concentration and radiographic knee osteoarthritis (OA).

Methods There were 2855 subjects in this cross-sectional study. Serum Mg concentration was measured using the chemiluminescence method. Radiographic OA of the knee was defined as changes consistent with Kellgren-Lawrence (K-L) grade 2 on at least 1 side. Mg concentration was classified into 1 of 4 quartiles: ≤ 0.87, 0.88–0.91, 0.92–0.96, or ≥ 0.97 mmol/l. Multivariable logistic analysis was used to test the association between serum Mg and radiographic knee OA after adjustment for potentially confounding factors. The OR with 95% CI for the association between radiographic knee OA and serum Mg concentration were calculated for each quartile. The quartile with the lowest value was regarded as the reference category.

Results Significant association between serum Mg concentration and radiographic knee OA was observed in the model after adjustment for age, sex, and body mass index, as well as in the multivariable model. The multivariable-adjusted OR (95% CI) for radiographic knee OA in the second, third, and fourth serum Mg concentration quartiles were 0.90 (95% CI 0.71–1.13), 0.92 (95% CI 0.73–1.16), and 0.72 (95% CI 0.57–0.92), respectively, compared with the lowest (first) quartile. A clear trend (p for trend was 0.01) was observed. The relative odds of radiographic knee OA was decreased by 0.72 times in the fourth serum Mg quartile compared with the lowest quartile.

Conclusion Serum Mg concentration may have an inverse relationship with radiographic OA of the knee.

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Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis
Chao Zeng, Jie Wei, Hui Li, Tuo Yang, Fang-Jie Zhang, Ding Pan, Yong-Bing Xiao, Tu-Bao Yang, Guang-Hua Lei
The Journal of Rheumatology Jun 2015, jrheum.141414; DOI: 10.3899/jrheum.141414

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Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis
Chao Zeng, Jie Wei, Hui Li, Tuo Yang, Fang-Jie Zhang, Ding Pan, Yong-Bing Xiao, Tu-Bao Yang, Guang-Hua Lei
The Journal of Rheumatology Jun 2015, jrheum.141414; DOI: 10.3899/jrheum.141414
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