Research ArticleArticle
The Circulating Cell-free microRNA Profile in Systemic Sclerosis Is Distinct from Both Healthy Controls and Systemic Lupus Erythematosus
Samantha O. Steen, Line V. Iversen, Anting Liu Carlsen, Mark Burton, Christoffer T. Nielsen, Søren Jacobsen and Niels H.H. Heegaard
The Journal of Rheumatology November 2014, jrheum.140502; DOI: https://doi.org/10.3899/jrheum.140502
Samantha O. Steen
From the Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; Department of Dermatology, Bispebjerg Hospital, and the Department of Rheumatology, Rigshospitalet, University of Copenhagen, Copenhagen; Department of Clinical Genetics, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense; Research Unit of Human Genetics, and Clinical Biochemistry, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. Supported by the Foundation for the Advancement of Medical Research, Bang’s Foundation, and the Danish Rheumatism Association (R99-A1937). S.O. Steen, MSc; A.L. Carlsen, PhD, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; L.V. Iversen, MD, PhD, Department of Dermatology, Bispebjerg Hospital, University of Copenhagen; M. Burton, PhD, Department of Clinical Genetics, Odense University Hospital, and the Institute of Clinical Research, Research Unit of Human Genetics, University of Southern Denmark; C.T. Nielsen, MD, PhD; S. Jacobsen, MD, DMedSc, Department of Rheumatology, Rigshospitalet, University of Copenhagen; N.H.H. Heegaard, MD, DMedSc, DNatSc, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, and the Institute of Clinical Research, Clinical Biochemistry, University of Southern Denmark. Address correspondence to Dr. N. Heegaard, Department of Autoimmunology and Biomarkers, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark. E-mail: nhe@ssi.dk. Accepted for publication October 1, 2014.
Line V. Iversen
From the Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; Department of Dermatology, Bispebjerg Hospital, and the Department of Rheumatology, Rigshospitalet, University of Copenhagen, Copenhagen; Department of Clinical Genetics, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense; Research Unit of Human Genetics, and Clinical Biochemistry, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. Supported by the Foundation for the Advancement of Medical Research, Bang’s Foundation, and the Danish Rheumatism Association (R99-A1937). S.O. Steen, MSc; A.L. Carlsen, PhD, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; L.V. Iversen, MD, PhD, Department of Dermatology, Bispebjerg Hospital, University of Copenhagen; M. Burton, PhD, Department of Clinical Genetics, Odense University Hospital, and the Institute of Clinical Research, Research Unit of Human Genetics, University of Southern Denmark; C.T. Nielsen, MD, PhD; S. Jacobsen, MD, DMedSc, Department of Rheumatology, Rigshospitalet, University of Copenhagen; N.H.H. Heegaard, MD, DMedSc, DNatSc, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, and the Institute of Clinical Research, Clinical Biochemistry, University of Southern Denmark. Address correspondence to Dr. N. Heegaard, Department of Autoimmunology and Biomarkers, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark. E-mail: nhe@ssi.dk. Accepted for publication October 1, 2014.
Anting Liu Carlsen
From the Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; Department of Dermatology, Bispebjerg Hospital, and the Department of Rheumatology, Rigshospitalet, University of Copenhagen, Copenhagen; Department of Clinical Genetics, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense; Research Unit of Human Genetics, and Clinical Biochemistry, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. Supported by the Foundation for the Advancement of Medical Research, Bang’s Foundation, and the Danish Rheumatism Association (R99-A1937). S.O. Steen, MSc; A.L. Carlsen, PhD, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; L.V. Iversen, MD, PhD, Department of Dermatology, Bispebjerg Hospital, University of Copenhagen; M. Burton, PhD, Department of Clinical Genetics, Odense University Hospital, and the Institute of Clinical Research, Research Unit of Human Genetics, University of Southern Denmark; C.T. Nielsen, MD, PhD; S. Jacobsen, MD, DMedSc, Department of Rheumatology, Rigshospitalet, University of Copenhagen; N.H.H. Heegaard, MD, DMedSc, DNatSc, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, and the Institute of Clinical Research, Clinical Biochemistry, University of Southern Denmark. Address correspondence to Dr. N. Heegaard, Department of Autoimmunology and Biomarkers, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark. E-mail: nhe@ssi.dk. Accepted for publication October 1, 2014.
Mark Burton
From the Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; Department of Dermatology, Bispebjerg Hospital, and the Department of Rheumatology, Rigshospitalet, University of Copenhagen, Copenhagen; Department of Clinical Genetics, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense; Research Unit of Human Genetics, and Clinical Biochemistry, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. Supported by the Foundation for the Advancement of Medical Research, Bang’s Foundation, and the Danish Rheumatism Association (R99-A1937). S.O. Steen, MSc; A.L. Carlsen, PhD, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; L.V. Iversen, MD, PhD, Department of Dermatology, Bispebjerg Hospital, University of Copenhagen; M. Burton, PhD, Department of Clinical Genetics, Odense University Hospital, and the Institute of Clinical Research, Research Unit of Human Genetics, University of Southern Denmark; C.T. Nielsen, MD, PhD; S. Jacobsen, MD, DMedSc, Department of Rheumatology, Rigshospitalet, University of Copenhagen; N.H.H. Heegaard, MD, DMedSc, DNatSc, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, and the Institute of Clinical Research, Clinical Biochemistry, University of Southern Denmark. Address correspondence to Dr. N. Heegaard, Department of Autoimmunology and Biomarkers, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark. E-mail: nhe@ssi.dk. Accepted for publication October 1, 2014.
Christoffer T. Nielsen
From the Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; Department of Dermatology, Bispebjerg Hospital, and the Department of Rheumatology, Rigshospitalet, University of Copenhagen, Copenhagen; Department of Clinical Genetics, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense; Research Unit of Human Genetics, and Clinical Biochemistry, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. Supported by the Foundation for the Advancement of Medical Research, Bang’s Foundation, and the Danish Rheumatism Association (R99-A1937). S.O. Steen, MSc; A.L. Carlsen, PhD, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; L.V. Iversen, MD, PhD, Department of Dermatology, Bispebjerg Hospital, University of Copenhagen; M. Burton, PhD, Department of Clinical Genetics, Odense University Hospital, and the Institute of Clinical Research, Research Unit of Human Genetics, University of Southern Denmark; C.T. Nielsen, MD, PhD; S. Jacobsen, MD, DMedSc, Department of Rheumatology, Rigshospitalet, University of Copenhagen; N.H.H. Heegaard, MD, DMedSc, DNatSc, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, and the Institute of Clinical Research, Clinical Biochemistry, University of Southern Denmark. Address correspondence to Dr. N. Heegaard, Department of Autoimmunology and Biomarkers, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark. E-mail: nhe@ssi.dk. Accepted for publication October 1, 2014.
Søren Jacobsen
From the Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; Department of Dermatology, Bispebjerg Hospital, and the Department of Rheumatology, Rigshospitalet, University of Copenhagen, Copenhagen; Department of Clinical Genetics, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense; Research Unit of Human Genetics, and Clinical Biochemistry, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. Supported by the Foundation for the Advancement of Medical Research, Bang’s Foundation, and the Danish Rheumatism Association (R99-A1937). S.O. Steen, MSc; A.L. Carlsen, PhD, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; L.V. Iversen, MD, PhD, Department of Dermatology, Bispebjerg Hospital, University of Copenhagen; M. Burton, PhD, Department of Clinical Genetics, Odense University Hospital, and the Institute of Clinical Research, Research Unit of Human Genetics, University of Southern Denmark; C.T. Nielsen, MD, PhD; S. Jacobsen, MD, DMedSc, Department of Rheumatology, Rigshospitalet, University of Copenhagen; N.H.H. Heegaard, MD, DMedSc, DNatSc, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, and the Institute of Clinical Research, Clinical Biochemistry, University of Southern Denmark. Address correspondence to Dr. N. Heegaard, Department of Autoimmunology and Biomarkers, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark. E-mail: nhe@ssi.dk. Accepted for publication October 1, 2014.
Niels H.H. Heegaard
From the Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; Department of Dermatology, Bispebjerg Hospital, and the Department of Rheumatology, Rigshospitalet, University of Copenhagen, Copenhagen; Department of Clinical Genetics, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense; Research Unit of Human Genetics, and Clinical Biochemistry, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. Supported by the Foundation for the Advancement of Medical Research, Bang’s Foundation, and the Danish Rheumatism Association (R99-A1937). S.O. Steen, MSc; A.L. Carlsen, PhD, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut; L.V. Iversen, MD, PhD, Department of Dermatology, Bispebjerg Hospital, University of Copenhagen; M. Burton, PhD, Department of Clinical Genetics, Odense University Hospital, and the Institute of Clinical Research, Research Unit of Human Genetics, University of Southern Denmark; C.T. Nielsen, MD, PhD; S. Jacobsen, MD, DMedSc, Department of Rheumatology, Rigshospitalet, University of Copenhagen; N.H.H. Heegaard, MD, DMedSc, DNatSc, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, and the Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, and the Institute of Clinical Research, Clinical Biochemistry, University of Southern Denmark. Address correspondence to Dr. N. Heegaard, Department of Autoimmunology and Biomarkers, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark. E-mail: nhe@ssi.dk. Accepted for publication October 1, 2014.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
The Circulating Cell-free microRNA Profile in Systemic Sclerosis Is Distinct from Both Healthy Controls and Systemic Lupus Erythematosus
Samantha O. Steen, Line V. Iversen, Anting Liu Carlsen, Mark Burton, Christoffer T. Nielsen, Søren Jacobsen, Niels H.H. Heegaard
The Journal of Rheumatology Nov 2014, jrheum.140502; DOI: 10.3899/jrheum.140502
The Circulating Cell-free microRNA Profile in Systemic Sclerosis Is Distinct from Both Healthy Controls and Systemic Lupus Erythematosus
Samantha O. Steen, Line V. Iversen, Anting Liu Carlsen, Mark Burton, Christoffer T. Nielsen, Søren Jacobsen, Niels H.H. Heegaard
The Journal of Rheumatology Nov 2014, jrheum.140502; DOI: 10.3899/jrheum.140502