Research ArticleArticle
Application of the OMERACT Filter to Measures of Core Outcome Domains in Recent Clinical Studies of Acute Gout
William J. Taylor, David Redden, Nicola Dalbeth, H. Ralph Schumacher, N. Lawrence Edwards, Lee S. Simon, Markus R. John, Margaret N. Essex, Douglas J. Watson, Robert Evans, Keith Rome and Jasvinder A. Singh
The Journal of Rheumatology January 2014, jrheum.131245; DOI: https://doi.org/10.3899/jrheum.131245
William J. Taylor
From the Department of Medicine, University of Otago, Wellington, New Zealand; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Medicine, University of Auckland, Auckland, New Zealand; University of Pennsylvania and Veterans Affairs (VA) Medical Center, Philadelphia, Pennsylvania, USA; Department of Medicine, University of Florida, Gainesville, Florida, USA; SDG LLC, Cambridge, Massachusetts, USA; and Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG, Basel, Switzerland; Pfizer Inc., New York, New York, USA; Epidemiology, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, USA; Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, New Jersey, USA; Health & Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology, Auckland, New Zealand; and Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA. Supported with resources and use of facilities at the Birmingham VA Medical Center, Alabama, USA (J.A.S. and D. Redden). N. Dalbeth has received consulting fees from Ardea Biosciences, Metabolex, Novartis, and Takeda. Her institution has received funding from Fonterra, and she is a named inventor on a patent related to milk products and gout. H.R. Schumacher has been a consultant for Regeneron, Novartis, Pfizer, Savient, Ardea, Metabolex, and BioCryst, and he has received a grant from Takeda. N.L. Edwards has received consultant fees from Novartis, Takeda Pharmaceutical, Savient Pharmaceutical, Ardea Biosciences, Regeneron Pharmaceuticals, Metabolex Pharmaceuticals, and BioCryst Pharmaceuticals. L.L. Simon has served on the board of directors for Savient Pharmaceuticals, and has consulted for Takeda. M.R. John is employed by Novartis and sometimes owns shares in the company. M.N. Essex is employed by Pfizer and owns shares in the company. D.J. Watson is an employee of and owns stock in Merck & Co. Inc.; the marketing authorization holder for etoricoxib and sponsor of the etoricoxib clinical trials that contributed data for this work. R. Evans is employed by Regeneron and owns shares of stock. J.A. Singh has received research grants from Takeda and Savient and consultant fees from Savient, Takeda, Ardea, Regeneron, Allergan, URL Pharmaceuticals and Novartis. He is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies; a member of the American College of Rheumatology’s Guidelines Subcommittee of the Quality of Care Committee; and a member of the Veterans Affairs Rheumatology Field Advisory Committee. W.J. Taylor, PhD, FRACP, Associate Professor, Department of Medicine, University of Otago; D. Redden, PhD, Associate Professor, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham; N. Dalbeth, MD, FRACP, Associate Professor, Department of Medicine, University of Auckland; H.R. Schumacher, MD, Professor, University of Pennsylvania and VA Medical Center; N.L. Edwards, MD, Professor, Department of Medicine, University of Florida; L.S. Simon, MD, SDG LLC; M.R. John, MD, Global Program Medical Director, Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG; M.N. Essex, PharmD, Senior Medical Director, Pfizer Inc.; D.J. Watson, PhD, FISPE, Epidemiology, Merck Sharp & Dohme Corp.; R. Evans, PharmD, Senior Director, Clinical Sciences, Regeneron Pharmaceuticals; K. Rome, PhD, Professor, Health and Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology; J.A. Singh, MBBS, MPH, Associate Professor, Birmingham VA Medical Center and University of Alabama at Birmingham. Address correspondence to Prof. Taylor, Department of Medicine, University of Otago, PO Box 7343, Wellington, New Zealand. E-mail: will.taylor{at}otago.ac.nz
David Redden
From the Department of Medicine, University of Otago, Wellington, New Zealand; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Medicine, University of Auckland, Auckland, New Zealand; University of Pennsylvania and Veterans Affairs (VA) Medical Center, Philadelphia, Pennsylvania, USA; Department of Medicine, University of Florida, Gainesville, Florida, USA; SDG LLC, Cambridge, Massachusetts, USA; and Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG, Basel, Switzerland; Pfizer Inc., New York, New York, USA; Epidemiology, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, USA; Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, New Jersey, USA; Health & Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology, Auckland, New Zealand; and Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA. Supported with resources and use of facilities at the Birmingham VA Medical Center, Alabama, USA (J.A.S. and D. Redden). N. Dalbeth has received consulting fees from Ardea Biosciences, Metabolex, Novartis, and Takeda. Her institution has received funding from Fonterra, and she is a named inventor on a patent related to milk products and gout. H.R. Schumacher has been a consultant for Regeneron, Novartis, Pfizer, Savient, Ardea, Metabolex, and BioCryst, and he has received a grant from Takeda. N.L. Edwards has received consultant fees from Novartis, Takeda Pharmaceutical, Savient Pharmaceutical, Ardea Biosciences, Regeneron Pharmaceuticals, Metabolex Pharmaceuticals, and BioCryst Pharmaceuticals. L.L. Simon has served on the board of directors for Savient Pharmaceuticals, and has consulted for Takeda. M.R. John is employed by Novartis and sometimes owns shares in the company. M.N. Essex is employed by Pfizer and owns shares in the company. D.J. Watson is an employee of and owns stock in Merck & Co. Inc.; the marketing authorization holder for etoricoxib and sponsor of the etoricoxib clinical trials that contributed data for this work. R. Evans is employed by Regeneron and owns shares of stock. J.A. Singh has received research grants from Takeda and Savient and consultant fees from Savient, Takeda, Ardea, Regeneron, Allergan, URL Pharmaceuticals and Novartis. He is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies; a member of the American College of Rheumatology’s Guidelines Subcommittee of the Quality of Care Committee; and a member of the Veterans Affairs Rheumatology Field Advisory Committee. W.J. Taylor, PhD, FRACP, Associate Professor, Department of Medicine, University of Otago; D. Redden, PhD, Associate Professor, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham; N. Dalbeth, MD, FRACP, Associate Professor, Department of Medicine, University of Auckland; H.R. Schumacher, MD, Professor, University of Pennsylvania and VA Medical Center; N.L. Edwards, MD, Professor, Department of Medicine, University of Florida; L.S. Simon, MD, SDG LLC; M.R. John, MD, Global Program Medical Director, Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG; M.N. Essex, PharmD, Senior Medical Director, Pfizer Inc.; D.J. Watson, PhD, FISPE, Epidemiology, Merck Sharp & Dohme Corp.; R. Evans, PharmD, Senior Director, Clinical Sciences, Regeneron Pharmaceuticals; K. Rome, PhD, Professor, Health and Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology; J.A. Singh, MBBS, MPH, Associate Professor, Birmingham VA Medical Center and University of Alabama at Birmingham. Address correspondence to Prof. Taylor, Department of Medicine, University of Otago, PO Box 7343, Wellington, New Zealand. E-mail: will.taylor{at}otago.ac.nz
Nicola Dalbeth
From the Department of Medicine, University of Otago, Wellington, New Zealand; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Medicine, University of Auckland, Auckland, New Zealand; University of Pennsylvania and Veterans Affairs (VA) Medical Center, Philadelphia, Pennsylvania, USA; Department of Medicine, University of Florida, Gainesville, Florida, USA; SDG LLC, Cambridge, Massachusetts, USA; and Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG, Basel, Switzerland; Pfizer Inc., New York, New York, USA; Epidemiology, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, USA; Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, New Jersey, USA; Health & Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology, Auckland, New Zealand; and Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA. Supported with resources and use of facilities at the Birmingham VA Medical Center, Alabama, USA (J.A.S. and D. Redden). N. Dalbeth has received consulting fees from Ardea Biosciences, Metabolex, Novartis, and Takeda. Her institution has received funding from Fonterra, and she is a named inventor on a patent related to milk products and gout. H.R. Schumacher has been a consultant for Regeneron, Novartis, Pfizer, Savient, Ardea, Metabolex, and BioCryst, and he has received a grant from Takeda. N.L. Edwards has received consultant fees from Novartis, Takeda Pharmaceutical, Savient Pharmaceutical, Ardea Biosciences, Regeneron Pharmaceuticals, Metabolex Pharmaceuticals, and BioCryst Pharmaceuticals. L.L. Simon has served on the board of directors for Savient Pharmaceuticals, and has consulted for Takeda. M.R. John is employed by Novartis and sometimes owns shares in the company. M.N. Essex is employed by Pfizer and owns shares in the company. D.J. Watson is an employee of and owns stock in Merck & Co. Inc.; the marketing authorization holder for etoricoxib and sponsor of the etoricoxib clinical trials that contributed data for this work. R. Evans is employed by Regeneron and owns shares of stock. J.A. Singh has received research grants from Takeda and Savient and consultant fees from Savient, Takeda, Ardea, Regeneron, Allergan, URL Pharmaceuticals and Novartis. He is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies; a member of the American College of Rheumatology’s Guidelines Subcommittee of the Quality of Care Committee; and a member of the Veterans Affairs Rheumatology Field Advisory Committee. W.J. Taylor, PhD, FRACP, Associate Professor, Department of Medicine, University of Otago; D. Redden, PhD, Associate Professor, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham; N. Dalbeth, MD, FRACP, Associate Professor, Department of Medicine, University of Auckland; H.R. Schumacher, MD, Professor, University of Pennsylvania and VA Medical Center; N.L. Edwards, MD, Professor, Department of Medicine, University of Florida; L.S. Simon, MD, SDG LLC; M.R. John, MD, Global Program Medical Director, Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG; M.N. Essex, PharmD, Senior Medical Director, Pfizer Inc.; D.J. Watson, PhD, FISPE, Epidemiology, Merck Sharp & Dohme Corp.; R. Evans, PharmD, Senior Director, Clinical Sciences, Regeneron Pharmaceuticals; K. Rome, PhD, Professor, Health and Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology; J.A. Singh, MBBS, MPH, Associate Professor, Birmingham VA Medical Center and University of Alabama at Birmingham. Address correspondence to Prof. Taylor, Department of Medicine, University of Otago, PO Box 7343, Wellington, New Zealand. E-mail: will.taylor{at}otago.ac.nz
H. Ralph Schumacher
From the Department of Medicine, University of Otago, Wellington, New Zealand; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Medicine, University of Auckland, Auckland, New Zealand; University of Pennsylvania and Veterans Affairs (VA) Medical Center, Philadelphia, Pennsylvania, USA; Department of Medicine, University of Florida, Gainesville, Florida, USA; SDG LLC, Cambridge, Massachusetts, USA; and Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG, Basel, Switzerland; Pfizer Inc., New York, New York, USA; Epidemiology, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, USA; Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, New Jersey, USA; Health & Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology, Auckland, New Zealand; and Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA. Supported with resources and use of facilities at the Birmingham VA Medical Center, Alabama, USA (J.A.S. and D. Redden). N. Dalbeth has received consulting fees from Ardea Biosciences, Metabolex, Novartis, and Takeda. Her institution has received funding from Fonterra, and she is a named inventor on a patent related to milk products and gout. H.R. Schumacher has been a consultant for Regeneron, Novartis, Pfizer, Savient, Ardea, Metabolex, and BioCryst, and he has received a grant from Takeda. N.L. Edwards has received consultant fees from Novartis, Takeda Pharmaceutical, Savient Pharmaceutical, Ardea Biosciences, Regeneron Pharmaceuticals, Metabolex Pharmaceuticals, and BioCryst Pharmaceuticals. L.L. Simon has served on the board of directors for Savient Pharmaceuticals, and has consulted for Takeda. M.R. John is employed by Novartis and sometimes owns shares in the company. M.N. Essex is employed by Pfizer and owns shares in the company. D.J. Watson is an employee of and owns stock in Merck & Co. Inc.; the marketing authorization holder for etoricoxib and sponsor of the etoricoxib clinical trials that contributed data for this work. R. Evans is employed by Regeneron and owns shares of stock. J.A. Singh has received research grants from Takeda and Savient and consultant fees from Savient, Takeda, Ardea, Regeneron, Allergan, URL Pharmaceuticals and Novartis. He is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies; a member of the American College of Rheumatology’s Guidelines Subcommittee of the Quality of Care Committee; and a member of the Veterans Affairs Rheumatology Field Advisory Committee. W.J. Taylor, PhD, FRACP, Associate Professor, Department of Medicine, University of Otago; D. Redden, PhD, Associate Professor, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham; N. Dalbeth, MD, FRACP, Associate Professor, Department of Medicine, University of Auckland; H.R. Schumacher, MD, Professor, University of Pennsylvania and VA Medical Center; N.L. Edwards, MD, Professor, Department of Medicine, University of Florida; L.S. Simon, MD, SDG LLC; M.R. John, MD, Global Program Medical Director, Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG; M.N. Essex, PharmD, Senior Medical Director, Pfizer Inc.; D.J. Watson, PhD, FISPE, Epidemiology, Merck Sharp & Dohme Corp.; R. Evans, PharmD, Senior Director, Clinical Sciences, Regeneron Pharmaceuticals; K. Rome, PhD, Professor, Health and Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology; J.A. Singh, MBBS, MPH, Associate Professor, Birmingham VA Medical Center and University of Alabama at Birmingham. Address correspondence to Prof. Taylor, Department of Medicine, University of Otago, PO Box 7343, Wellington, New Zealand. E-mail: will.taylor{at}otago.ac.nz
N. Lawrence Edwards
From the Department of Medicine, University of Otago, Wellington, New Zealand; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Medicine, University of Auckland, Auckland, New Zealand; University of Pennsylvania and Veterans Affairs (VA) Medical Center, Philadelphia, Pennsylvania, USA; Department of Medicine, University of Florida, Gainesville, Florida, USA; SDG LLC, Cambridge, Massachusetts, USA; and Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG, Basel, Switzerland; Pfizer Inc., New York, New York, USA; Epidemiology, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, USA; Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, New Jersey, USA; Health & Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology, Auckland, New Zealand; and Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA. Supported with resources and use of facilities at the Birmingham VA Medical Center, Alabama, USA (J.A.S. and D. Redden). N. Dalbeth has received consulting fees from Ardea Biosciences, Metabolex, Novartis, and Takeda. Her institution has received funding from Fonterra, and she is a named inventor on a patent related to milk products and gout. H.R. Schumacher has been a consultant for Regeneron, Novartis, Pfizer, Savient, Ardea, Metabolex, and BioCryst, and he has received a grant from Takeda. N.L. Edwards has received consultant fees from Novartis, Takeda Pharmaceutical, Savient Pharmaceutical, Ardea Biosciences, Regeneron Pharmaceuticals, Metabolex Pharmaceuticals, and BioCryst Pharmaceuticals. L.L. Simon has served on the board of directors for Savient Pharmaceuticals, and has consulted for Takeda. M.R. John is employed by Novartis and sometimes owns shares in the company. M.N. Essex is employed by Pfizer and owns shares in the company. D.J. Watson is an employee of and owns stock in Merck & Co. Inc.; the marketing authorization holder for etoricoxib and sponsor of the etoricoxib clinical trials that contributed data for this work. R. Evans is employed by Regeneron and owns shares of stock. J.A. Singh has received research grants from Takeda and Savient and consultant fees from Savient, Takeda, Ardea, Regeneron, Allergan, URL Pharmaceuticals and Novartis. He is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies; a member of the American College of Rheumatology’s Guidelines Subcommittee of the Quality of Care Committee; and a member of the Veterans Affairs Rheumatology Field Advisory Committee. W.J. Taylor, PhD, FRACP, Associate Professor, Department of Medicine, University of Otago; D. Redden, PhD, Associate Professor, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham; N. Dalbeth, MD, FRACP, Associate Professor, Department of Medicine, University of Auckland; H.R. Schumacher, MD, Professor, University of Pennsylvania and VA Medical Center; N.L. Edwards, MD, Professor, Department of Medicine, University of Florida; L.S. Simon, MD, SDG LLC; M.R. John, MD, Global Program Medical Director, Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG; M.N. Essex, PharmD, Senior Medical Director, Pfizer Inc.; D.J. Watson, PhD, FISPE, Epidemiology, Merck Sharp & Dohme Corp.; R. Evans, PharmD, Senior Director, Clinical Sciences, Regeneron Pharmaceuticals; K. Rome, PhD, Professor, Health and Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology; J.A. Singh, MBBS, MPH, Associate Professor, Birmingham VA Medical Center and University of Alabama at Birmingham. Address correspondence to Prof. Taylor, Department of Medicine, University of Otago, PO Box 7343, Wellington, New Zealand. E-mail: will.taylor{at}otago.ac.nz
Lee S. Simon
From the Department of Medicine, University of Otago, Wellington, New Zealand; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Medicine, University of Auckland, Auckland, New Zealand; University of Pennsylvania and Veterans Affairs (VA) Medical Center, Philadelphia, Pennsylvania, USA; Department of Medicine, University of Florida, Gainesville, Florida, USA; SDG LLC, Cambridge, Massachusetts, USA; and Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG, Basel, Switzerland; Pfizer Inc., New York, New York, USA; Epidemiology, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, USA; Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, New Jersey, USA; Health & Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology, Auckland, New Zealand; and Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA. Supported with resources and use of facilities at the Birmingham VA Medical Center, Alabama, USA (J.A.S. and D. Redden). N. Dalbeth has received consulting fees from Ardea Biosciences, Metabolex, Novartis, and Takeda. Her institution has received funding from Fonterra, and she is a named inventor on a patent related to milk products and gout. H.R. Schumacher has been a consultant for Regeneron, Novartis, Pfizer, Savient, Ardea, Metabolex, and BioCryst, and he has received a grant from Takeda. N.L. Edwards has received consultant fees from Novartis, Takeda Pharmaceutical, Savient Pharmaceutical, Ardea Biosciences, Regeneron Pharmaceuticals, Metabolex Pharmaceuticals, and BioCryst Pharmaceuticals. L.L. Simon has served on the board of directors for Savient Pharmaceuticals, and has consulted for Takeda. M.R. John is employed by Novartis and sometimes owns shares in the company. M.N. Essex is employed by Pfizer and owns shares in the company. D.J. Watson is an employee of and owns stock in Merck & Co. Inc.; the marketing authorization holder for etoricoxib and sponsor of the etoricoxib clinical trials that contributed data for this work. R. Evans is employed by Regeneron and owns shares of stock. J.A. Singh has received research grants from Takeda and Savient and consultant fees from Savient, Takeda, Ardea, Regeneron, Allergan, URL Pharmaceuticals and Novartis. He is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies; a member of the American College of Rheumatology’s Guidelines Subcommittee of the Quality of Care Committee; and a member of the Veterans Affairs Rheumatology Field Advisory Committee. W.J. Taylor, PhD, FRACP, Associate Professor, Department of Medicine, University of Otago; D. Redden, PhD, Associate Professor, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham; N. Dalbeth, MD, FRACP, Associate Professor, Department of Medicine, University of Auckland; H.R. Schumacher, MD, Professor, University of Pennsylvania and VA Medical Center; N.L. Edwards, MD, Professor, Department of Medicine, University of Florida; L.S. Simon, MD, SDG LLC; M.R. John, MD, Global Program Medical Director, Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG; M.N. Essex, PharmD, Senior Medical Director, Pfizer Inc.; D.J. Watson, PhD, FISPE, Epidemiology, Merck Sharp & Dohme Corp.; R. Evans, PharmD, Senior Director, Clinical Sciences, Regeneron Pharmaceuticals; K. Rome, PhD, Professor, Health and Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology; J.A. Singh, MBBS, MPH, Associate Professor, Birmingham VA Medical Center and University of Alabama at Birmingham. Address correspondence to Prof. Taylor, Department of Medicine, University of Otago, PO Box 7343, Wellington, New Zealand. E-mail: will.taylor{at}otago.ac.nz
Markus R. John
From the Department of Medicine, University of Otago, Wellington, New Zealand; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Medicine, University of Auckland, Auckland, New Zealand; University of Pennsylvania and Veterans Affairs (VA) Medical Center, Philadelphia, Pennsylvania, USA; Department of Medicine, University of Florida, Gainesville, Florida, USA; SDG LLC, Cambridge, Massachusetts, USA; and Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG, Basel, Switzerland; Pfizer Inc., New York, New York, USA; Epidemiology, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, USA; Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, New Jersey, USA; Health & Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology, Auckland, New Zealand; and Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA. Supported with resources and use of facilities at the Birmingham VA Medical Center, Alabama, USA (J.A.S. and D. Redden). N. Dalbeth has received consulting fees from Ardea Biosciences, Metabolex, Novartis, and Takeda. Her institution has received funding from Fonterra, and she is a named inventor on a patent related to milk products and gout. H.R. Schumacher has been a consultant for Regeneron, Novartis, Pfizer, Savient, Ardea, Metabolex, and BioCryst, and he has received a grant from Takeda. N.L. Edwards has received consultant fees from Novartis, Takeda Pharmaceutical, Savient Pharmaceutical, Ardea Biosciences, Regeneron Pharmaceuticals, Metabolex Pharmaceuticals, and BioCryst Pharmaceuticals. L.L. Simon has served on the board of directors for Savient Pharmaceuticals, and has consulted for Takeda. M.R. John is employed by Novartis and sometimes owns shares in the company. M.N. Essex is employed by Pfizer and owns shares in the company. D.J. Watson is an employee of and owns stock in Merck & Co. Inc.; the marketing authorization holder for etoricoxib and sponsor of the etoricoxib clinical trials that contributed data for this work. R. Evans is employed by Regeneron and owns shares of stock. J.A. Singh has received research grants from Takeda and Savient and consultant fees from Savient, Takeda, Ardea, Regeneron, Allergan, URL Pharmaceuticals and Novartis. He is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies; a member of the American College of Rheumatology’s Guidelines Subcommittee of the Quality of Care Committee; and a member of the Veterans Affairs Rheumatology Field Advisory Committee. W.J. Taylor, PhD, FRACP, Associate Professor, Department of Medicine, University of Otago; D. Redden, PhD, Associate Professor, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham; N. Dalbeth, MD, FRACP, Associate Professor, Department of Medicine, University of Auckland; H.R. Schumacher, MD, Professor, University of Pennsylvania and VA Medical Center; N.L. Edwards, MD, Professor, Department of Medicine, University of Florida; L.S. Simon, MD, SDG LLC; M.R. John, MD, Global Program Medical Director, Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG; M.N. Essex, PharmD, Senior Medical Director, Pfizer Inc.; D.J. Watson, PhD, FISPE, Epidemiology, Merck Sharp & Dohme Corp.; R. Evans, PharmD, Senior Director, Clinical Sciences, Regeneron Pharmaceuticals; K. Rome, PhD, Professor, Health and Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology; J.A. Singh, MBBS, MPH, Associate Professor, Birmingham VA Medical Center and University of Alabama at Birmingham. Address correspondence to Prof. Taylor, Department of Medicine, University of Otago, PO Box 7343, Wellington, New Zealand. E-mail: will.taylor{at}otago.ac.nz
Margaret N. Essex
From the Department of Medicine, University of Otago, Wellington, New Zealand; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Medicine, University of Auckland, Auckland, New Zealand; University of Pennsylvania and Veterans Affairs (VA) Medical Center, Philadelphia, Pennsylvania, USA; Department of Medicine, University of Florida, Gainesville, Florida, USA; SDG LLC, Cambridge, Massachusetts, USA; and Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG, Basel, Switzerland; Pfizer Inc., New York, New York, USA; Epidemiology, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, USA; Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, New Jersey, USA; Health & Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology, Auckland, New Zealand; and Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA. Supported with resources and use of facilities at the Birmingham VA Medical Center, Alabama, USA (J.A.S. and D. Redden). N. Dalbeth has received consulting fees from Ardea Biosciences, Metabolex, Novartis, and Takeda. Her institution has received funding from Fonterra, and she is a named inventor on a patent related to milk products and gout. H.R. Schumacher has been a consultant for Regeneron, Novartis, Pfizer, Savient, Ardea, Metabolex, and BioCryst, and he has received a grant from Takeda. N.L. Edwards has received consultant fees from Novartis, Takeda Pharmaceutical, Savient Pharmaceutical, Ardea Biosciences, Regeneron Pharmaceuticals, Metabolex Pharmaceuticals, and BioCryst Pharmaceuticals. L.L. Simon has served on the board of directors for Savient Pharmaceuticals, and has consulted for Takeda. M.R. John is employed by Novartis and sometimes owns shares in the company. M.N. Essex is employed by Pfizer and owns shares in the company. D.J. Watson is an employee of and owns stock in Merck & Co. Inc.; the marketing authorization holder for etoricoxib and sponsor of the etoricoxib clinical trials that contributed data for this work. R. Evans is employed by Regeneron and owns shares of stock. J.A. Singh has received research grants from Takeda and Savient and consultant fees from Savient, Takeda, Ardea, Regeneron, Allergan, URL Pharmaceuticals and Novartis. He is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies; a member of the American College of Rheumatology’s Guidelines Subcommittee of the Quality of Care Committee; and a member of the Veterans Affairs Rheumatology Field Advisory Committee. W.J. Taylor, PhD, FRACP, Associate Professor, Department of Medicine, University of Otago; D. Redden, PhD, Associate Professor, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham; N. Dalbeth, MD, FRACP, Associate Professor, Department of Medicine, University of Auckland; H.R. Schumacher, MD, Professor, University of Pennsylvania and VA Medical Center; N.L. Edwards, MD, Professor, Department of Medicine, University of Florida; L.S. Simon, MD, SDG LLC; M.R. John, MD, Global Program Medical Director, Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG; M.N. Essex, PharmD, Senior Medical Director, Pfizer Inc.; D.J. Watson, PhD, FISPE, Epidemiology, Merck Sharp & Dohme Corp.; R. Evans, PharmD, Senior Director, Clinical Sciences, Regeneron Pharmaceuticals; K. Rome, PhD, Professor, Health and Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology; J.A. Singh, MBBS, MPH, Associate Professor, Birmingham VA Medical Center and University of Alabama at Birmingham. Address correspondence to Prof. Taylor, Department of Medicine, University of Otago, PO Box 7343, Wellington, New Zealand. E-mail: will.taylor{at}otago.ac.nz
Douglas J. Watson
From the Department of Medicine, University of Otago, Wellington, New Zealand; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Medicine, University of Auckland, Auckland, New Zealand; University of Pennsylvania and Veterans Affairs (VA) Medical Center, Philadelphia, Pennsylvania, USA; Department of Medicine, University of Florida, Gainesville, Florida, USA; SDG LLC, Cambridge, Massachusetts, USA; and Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG, Basel, Switzerland; Pfizer Inc., New York, New York, USA; Epidemiology, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, USA; Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, New Jersey, USA; Health & Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology, Auckland, New Zealand; and Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA. Supported with resources and use of facilities at the Birmingham VA Medical Center, Alabama, USA (J.A.S. and D. Redden). N. Dalbeth has received consulting fees from Ardea Biosciences, Metabolex, Novartis, and Takeda. Her institution has received funding from Fonterra, and she is a named inventor on a patent related to milk products and gout. H.R. Schumacher has been a consultant for Regeneron, Novartis, Pfizer, Savient, Ardea, Metabolex, and BioCryst, and he has received a grant from Takeda. N.L. Edwards has received consultant fees from Novartis, Takeda Pharmaceutical, Savient Pharmaceutical, Ardea Biosciences, Regeneron Pharmaceuticals, Metabolex Pharmaceuticals, and BioCryst Pharmaceuticals. L.L. Simon has served on the board of directors for Savient Pharmaceuticals, and has consulted for Takeda. M.R. John is employed by Novartis and sometimes owns shares in the company. M.N. Essex is employed by Pfizer and owns shares in the company. D.J. Watson is an employee of and owns stock in Merck & Co. Inc.; the marketing authorization holder for etoricoxib and sponsor of the etoricoxib clinical trials that contributed data for this work. R. Evans is employed by Regeneron and owns shares of stock. J.A. Singh has received research grants from Takeda and Savient and consultant fees from Savient, Takeda, Ardea, Regeneron, Allergan, URL Pharmaceuticals and Novartis. He is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies; a member of the American College of Rheumatology’s Guidelines Subcommittee of the Quality of Care Committee; and a member of the Veterans Affairs Rheumatology Field Advisory Committee. W.J. Taylor, PhD, FRACP, Associate Professor, Department of Medicine, University of Otago; D. Redden, PhD, Associate Professor, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham; N. Dalbeth, MD, FRACP, Associate Professor, Department of Medicine, University of Auckland; H.R. Schumacher, MD, Professor, University of Pennsylvania and VA Medical Center; N.L. Edwards, MD, Professor, Department of Medicine, University of Florida; L.S. Simon, MD, SDG LLC; M.R. John, MD, Global Program Medical Director, Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG; M.N. Essex, PharmD, Senior Medical Director, Pfizer Inc.; D.J. Watson, PhD, FISPE, Epidemiology, Merck Sharp & Dohme Corp.; R. Evans, PharmD, Senior Director, Clinical Sciences, Regeneron Pharmaceuticals; K. Rome, PhD, Professor, Health and Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology; J.A. Singh, MBBS, MPH, Associate Professor, Birmingham VA Medical Center and University of Alabama at Birmingham. Address correspondence to Prof. Taylor, Department of Medicine, University of Otago, PO Box 7343, Wellington, New Zealand. E-mail: will.taylor{at}otago.ac.nz
Robert Evans
From the Department of Medicine, University of Otago, Wellington, New Zealand; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Medicine, University of Auckland, Auckland, New Zealand; University of Pennsylvania and Veterans Affairs (VA) Medical Center, Philadelphia, Pennsylvania, USA; Department of Medicine, University of Florida, Gainesville, Florida, USA; SDG LLC, Cambridge, Massachusetts, USA; and Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG, Basel, Switzerland; Pfizer Inc., New York, New York, USA; Epidemiology, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, USA; Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, New Jersey, USA; Health & Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology, Auckland, New Zealand; and Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA. Supported with resources and use of facilities at the Birmingham VA Medical Center, Alabama, USA (J.A.S. and D. Redden). N. Dalbeth has received consulting fees from Ardea Biosciences, Metabolex, Novartis, and Takeda. Her institution has received funding from Fonterra, and she is a named inventor on a patent related to milk products and gout. H.R. Schumacher has been a consultant for Regeneron, Novartis, Pfizer, Savient, Ardea, Metabolex, and BioCryst, and he has received a grant from Takeda. N.L. Edwards has received consultant fees from Novartis, Takeda Pharmaceutical, Savient Pharmaceutical, Ardea Biosciences, Regeneron Pharmaceuticals, Metabolex Pharmaceuticals, and BioCryst Pharmaceuticals. L.L. Simon has served on the board of directors for Savient Pharmaceuticals, and has consulted for Takeda. M.R. John is employed by Novartis and sometimes owns shares in the company. M.N. Essex is employed by Pfizer and owns shares in the company. D.J. Watson is an employee of and owns stock in Merck & Co. Inc.; the marketing authorization holder for etoricoxib and sponsor of the etoricoxib clinical trials that contributed data for this work. R. Evans is employed by Regeneron and owns shares of stock. J.A. Singh has received research grants from Takeda and Savient and consultant fees from Savient, Takeda, Ardea, Regeneron, Allergan, URL Pharmaceuticals and Novartis. He is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies; a member of the American College of Rheumatology’s Guidelines Subcommittee of the Quality of Care Committee; and a member of the Veterans Affairs Rheumatology Field Advisory Committee. W.J. Taylor, PhD, FRACP, Associate Professor, Department of Medicine, University of Otago; D. Redden, PhD, Associate Professor, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham; N. Dalbeth, MD, FRACP, Associate Professor, Department of Medicine, University of Auckland; H.R. Schumacher, MD, Professor, University of Pennsylvania and VA Medical Center; N.L. Edwards, MD, Professor, Department of Medicine, University of Florida; L.S. Simon, MD, SDG LLC; M.R. John, MD, Global Program Medical Director, Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG; M.N. Essex, PharmD, Senior Medical Director, Pfizer Inc.; D.J. Watson, PhD, FISPE, Epidemiology, Merck Sharp & Dohme Corp.; R. Evans, PharmD, Senior Director, Clinical Sciences, Regeneron Pharmaceuticals; K. Rome, PhD, Professor, Health and Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology; J.A. Singh, MBBS, MPH, Associate Professor, Birmingham VA Medical Center and University of Alabama at Birmingham. Address correspondence to Prof. Taylor, Department of Medicine, University of Otago, PO Box 7343, Wellington, New Zealand. E-mail: will.taylor{at}otago.ac.nz
Keith Rome
From the Department of Medicine, University of Otago, Wellington, New Zealand; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Medicine, University of Auckland, Auckland, New Zealand; University of Pennsylvania and Veterans Affairs (VA) Medical Center, Philadelphia, Pennsylvania, USA; Department of Medicine, University of Florida, Gainesville, Florida, USA; SDG LLC, Cambridge, Massachusetts, USA; and Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG, Basel, Switzerland; Pfizer Inc., New York, New York, USA; Epidemiology, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, USA; Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, New Jersey, USA; Health & Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology, Auckland, New Zealand; and Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA. Supported with resources and use of facilities at the Birmingham VA Medical Center, Alabama, USA (J.A.S. and D. Redden). N. Dalbeth has received consulting fees from Ardea Biosciences, Metabolex, Novartis, and Takeda. Her institution has received funding from Fonterra, and she is a named inventor on a patent related to milk products and gout. H.R. Schumacher has been a consultant for Regeneron, Novartis, Pfizer, Savient, Ardea, Metabolex, and BioCryst, and he has received a grant from Takeda. N.L. Edwards has received consultant fees from Novartis, Takeda Pharmaceutical, Savient Pharmaceutical, Ardea Biosciences, Regeneron Pharmaceuticals, Metabolex Pharmaceuticals, and BioCryst Pharmaceuticals. L.L. Simon has served on the board of directors for Savient Pharmaceuticals, and has consulted for Takeda. M.R. John is employed by Novartis and sometimes owns shares in the company. M.N. Essex is employed by Pfizer and owns shares in the company. D.J. Watson is an employee of and owns stock in Merck & Co. Inc.; the marketing authorization holder for etoricoxib and sponsor of the etoricoxib clinical trials that contributed data for this work. R. Evans is employed by Regeneron and owns shares of stock. J.A. Singh has received research grants from Takeda and Savient and consultant fees from Savient, Takeda, Ardea, Regeneron, Allergan, URL Pharmaceuticals and Novartis. He is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies; a member of the American College of Rheumatology’s Guidelines Subcommittee of the Quality of Care Committee; and a member of the Veterans Affairs Rheumatology Field Advisory Committee. W.J. Taylor, PhD, FRACP, Associate Professor, Department of Medicine, University of Otago; D. Redden, PhD, Associate Professor, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham; N. Dalbeth, MD, FRACP, Associate Professor, Department of Medicine, University of Auckland; H.R. Schumacher, MD, Professor, University of Pennsylvania and VA Medical Center; N.L. Edwards, MD, Professor, Department of Medicine, University of Florida; L.S. Simon, MD, SDG LLC; M.R. John, MD, Global Program Medical Director, Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG; M.N. Essex, PharmD, Senior Medical Director, Pfizer Inc.; D.J. Watson, PhD, FISPE, Epidemiology, Merck Sharp & Dohme Corp.; R. Evans, PharmD, Senior Director, Clinical Sciences, Regeneron Pharmaceuticals; K. Rome, PhD, Professor, Health and Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology; J.A. Singh, MBBS, MPH, Associate Professor, Birmingham VA Medical Center and University of Alabama at Birmingham. Address correspondence to Prof. Taylor, Department of Medicine, University of Otago, PO Box 7343, Wellington, New Zealand. E-mail: will.taylor{at}otago.ac.nz
Jasvinder A. Singh
From the Department of Medicine, University of Otago, Wellington, New Zealand; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Medicine, University of Auckland, Auckland, New Zealand; University of Pennsylvania and Veterans Affairs (VA) Medical Center, Philadelphia, Pennsylvania, USA; Department of Medicine, University of Florida, Gainesville, Florida, USA; SDG LLC, Cambridge, Massachusetts, USA; and Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG, Basel, Switzerland; Pfizer Inc., New York, New York, USA; Epidemiology, Merck Sharp & Dohme Corp., Whitehouse Station, New Jersey, USA; Clinical Sciences, Regeneron Pharmaceuticals, Tarrytown, New Jersey, USA; Health & Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology, Auckland, New Zealand; and Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA. Supported with resources and use of facilities at the Birmingham VA Medical Center, Alabama, USA (J.A.S. and D. Redden). N. Dalbeth has received consulting fees from Ardea Biosciences, Metabolex, Novartis, and Takeda. Her institution has received funding from Fonterra, and she is a named inventor on a patent related to milk products and gout. H.R. Schumacher has been a consultant for Regeneron, Novartis, Pfizer, Savient, Ardea, Metabolex, and BioCryst, and he has received a grant from Takeda. N.L. Edwards has received consultant fees from Novartis, Takeda Pharmaceutical, Savient Pharmaceutical, Ardea Biosciences, Regeneron Pharmaceuticals, Metabolex Pharmaceuticals, and BioCryst Pharmaceuticals. L.L. Simon has served on the board of directors for Savient Pharmaceuticals, and has consulted for Takeda. M.R. John is employed by Novartis and sometimes owns shares in the company. M.N. Essex is employed by Pfizer and owns shares in the company. D.J. Watson is an employee of and owns stock in Merck & Co. Inc.; the marketing authorization holder for etoricoxib and sponsor of the etoricoxib clinical trials that contributed data for this work. R. Evans is employed by Regeneron and owns shares of stock. J.A. Singh has received research grants from Takeda and Savient and consultant fees from Savient, Takeda, Ardea, Regeneron, Allergan, URL Pharmaceuticals and Novartis. He is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies; a member of the American College of Rheumatology’s Guidelines Subcommittee of the Quality of Care Committee; and a member of the Veterans Affairs Rheumatology Field Advisory Committee. W.J. Taylor, PhD, FRACP, Associate Professor, Department of Medicine, University of Otago; D. Redden, PhD, Associate Professor, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham; N. Dalbeth, MD, FRACP, Associate Professor, Department of Medicine, University of Auckland; H.R. Schumacher, MD, Professor, University of Pennsylvania and VA Medical Center; N.L. Edwards, MD, Professor, Department of Medicine, University of Florida; L.S. Simon, MD, SDG LLC; M.R. John, MD, Global Program Medical Director, Integrated Hospital Care Franchise, Immunology, Novartis Pharma AG; M.N. Essex, PharmD, Senior Medical Director, Pfizer Inc.; D.J. Watson, PhD, FISPE, Epidemiology, Merck Sharp & Dohme Corp.; R. Evans, PharmD, Senior Director, Clinical Sciences, Regeneron Pharmaceuticals; K. Rome, PhD, Professor, Health and Rehabilitation Research Institute and School of Podiatry, Auckland University of Technology; J.A. Singh, MBBS, MPH, Associate Professor, Birmingham VA Medical Center and University of Alabama at Birmingham. Address correspondence to Prof. Taylor, Department of Medicine, University of Otago, PO Box 7343, Wellington, New Zealand. E-mail: will.taylor{at}otago.ac.nz
Abstract
Objective To determine the extent to which instruments that measure core outcome domains in acute gout fulfill the Outcome Measures in Rheumatology (OMERACT) filter requirements of truth, discrimination, and feasibility.
Methods Patient-level data from 4 randomized controlled trials of agents designed to treat acute gout and 1 observational study of acute gout were analyzed. For each available measure, construct validity, test-retest reliability, within-group change using effect size, between-group change using the Kruskall-Wallis statistic, and repeated measures generalized estimating equations were assessed. Floor and ceiling effects were also assessed and minimal clinically important difference was estimated. These analyses were presented to participants at OMERACT 11 to help inform voting for possible endorsement.
Results There was evidence for construct validity and discriminative ability for 3 measures of pain [0 to 4 Likert, 0 to 10 numeric rating scale (NRS), 0 to 100 mm visual analog scale (VAS)]. Likewise, there appears to be sufficient evidence for a 4-point Likert scale to possess construct validity and discriminative ability for physician assessment of joint swelling and joint tenderness. There was some evidence for construct validity and within-group discriminative ability for the Health Assessment Questionnaire as a measure of activity limitations, but not for discrimination between groups allocated to different treatment.
Conclusion There is sufficient evidence to support measures of pain (using Likert, NRS, or VAS), joint tenderness, and swelling (using Likert scale) as fulfilling the requirements of the OMERACT filter. Further research on a measure of activity limitations in acute gout clinical trials is required.
In this issue
The Journal of Rheumatology
Vol. 53, Issue 2
1 Feb 2026
Application of the OMERACT Filter to Measures of Core Outcome Domains in Recent Clinical Studies of Acute Gout
William J. Taylor, David Redden, Nicola Dalbeth, H. Ralph Schumacher, N. Lawrence Edwards, Lee S. Simon, Markus R. John, Margaret N. Essex, Douglas J. Watson, Robert Evans, Keith Rome, Jasvinder A. Singh
The Journal of Rheumatology Jan 2014, jrheum.131245; DOI: 10.3899/jrheum.131245
Application of the OMERACT Filter to Measures of Core Outcome Domains in Recent Clinical Studies of Acute Gout
William J. Taylor, David Redden, Nicola Dalbeth, H. Ralph Schumacher, N. Lawrence Edwards, Lee S. Simon, Markus R. John, Margaret N. Essex, Douglas J. Watson, Robert Evans, Keith Rome, Jasvinder A. Singh
The Journal of Rheumatology Jan 2014, jrheum.131245; DOI: 10.3899/jrheum.131245
