Research ArticleArticle
Early Local Swelling and Tenderness Are Associated with Large-joint Damage After 8 Years of Treatment to Target in Patients with Recent-onset Rheumatoid Arthritis
Marianne van den Broek, Linda Dirven, Herman M. Kroon, Margreet Kloppenburg, H. Karel Ronday, André J. Peeters, Pit J.S.M. Kerstens, Tom W.J. Huizinga, Willem F. Lems and Cornelia F. Allaart
The Journal of Rheumatology April 2013, jrheum.121248; DOI: https://doi.org/10.3899/jrheum.121248
Marianne van den Broek
From the Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden; Department of Radiology, LUMC, Leiden; Department of Rheumatology, Haga Hospital, The Hague; Department of Rheumatology, Reinier de Graaf Gasthuis, Delft; Department of Rheumatology, Jan van Breemen Research Institute, Reade, Amsterdam; and Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands. Supported by the Dutch College of Health Insurance Companies, Janssen B.V., and Schering-Plough Ltd. M. van den Broek, MD; L. Dirven, PhD, Department of Rheumatology, LUMC; H.M. Kroon, MD, PhD, Department of Radiology, LUMC; M. Kloppenburg, MD, PhD, Department of Rheumatology, LUMC; H.K. Ronday, MD, PhD, Department of Rheumatology, Haga Hospital; A.J. Peeters, MD, PhD, Department of Rheumatology, Reinier de Graaf Gasthuis; P.J.S.M. Kerstens, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; T.W.J. Huizinga, MD, PhD, Department of Rheumatology, LUMC; W.F. Lems, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; Department of Rheumatology, VU Medical Center; C.F. Allaart, MD, PhD, Department of Rheumatology, LUMC. M. van den Broek and L. Dirven contributed equally to this report. Address correspondence to Dr. M. van den Broek, Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: m.van_den_broek@lumc.nl Accepted for publication January 25, 2013.
Linda Dirven
From the Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden; Department of Radiology, LUMC, Leiden; Department of Rheumatology, Haga Hospital, The Hague; Department of Rheumatology, Reinier de Graaf Gasthuis, Delft; Department of Rheumatology, Jan van Breemen Research Institute, Reade, Amsterdam; and Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands. Supported by the Dutch College of Health Insurance Companies, Janssen B.V., and Schering-Plough Ltd. M. van den Broek, MD; L. Dirven, PhD, Department of Rheumatology, LUMC; H.M. Kroon, MD, PhD, Department of Radiology, LUMC; M. Kloppenburg, MD, PhD, Department of Rheumatology, LUMC; H.K. Ronday, MD, PhD, Department of Rheumatology, Haga Hospital; A.J. Peeters, MD, PhD, Department of Rheumatology, Reinier de Graaf Gasthuis; P.J.S.M. Kerstens, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; T.W.J. Huizinga, MD, PhD, Department of Rheumatology, LUMC; W.F. Lems, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; Department of Rheumatology, VU Medical Center; C.F. Allaart, MD, PhD, Department of Rheumatology, LUMC. M. van den Broek and L. Dirven contributed equally to this report. Address correspondence to Dr. M. van den Broek, Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: m.van_den_broek@lumc.nl Accepted for publication January 25, 2013.
Herman M. Kroon
From the Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden; Department of Radiology, LUMC, Leiden; Department of Rheumatology, Haga Hospital, The Hague; Department of Rheumatology, Reinier de Graaf Gasthuis, Delft; Department of Rheumatology, Jan van Breemen Research Institute, Reade, Amsterdam; and Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands. Supported by the Dutch College of Health Insurance Companies, Janssen B.V., and Schering-Plough Ltd. M. van den Broek, MD; L. Dirven, PhD, Department of Rheumatology, LUMC; H.M. Kroon, MD, PhD, Department of Radiology, LUMC; M. Kloppenburg, MD, PhD, Department of Rheumatology, LUMC; H.K. Ronday, MD, PhD, Department of Rheumatology, Haga Hospital; A.J. Peeters, MD, PhD, Department of Rheumatology, Reinier de Graaf Gasthuis; P.J.S.M. Kerstens, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; T.W.J. Huizinga, MD, PhD, Department of Rheumatology, LUMC; W.F. Lems, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; Department of Rheumatology, VU Medical Center; C.F. Allaart, MD, PhD, Department of Rheumatology, LUMC. M. van den Broek and L. Dirven contributed equally to this report. Address correspondence to Dr. M. van den Broek, Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: m.van_den_broek@lumc.nl Accepted for publication January 25, 2013.
Margreet Kloppenburg
From the Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden; Department of Radiology, LUMC, Leiden; Department of Rheumatology, Haga Hospital, The Hague; Department of Rheumatology, Reinier de Graaf Gasthuis, Delft; Department of Rheumatology, Jan van Breemen Research Institute, Reade, Amsterdam; and Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands. Supported by the Dutch College of Health Insurance Companies, Janssen B.V., and Schering-Plough Ltd. M. van den Broek, MD; L. Dirven, PhD, Department of Rheumatology, LUMC; H.M. Kroon, MD, PhD, Department of Radiology, LUMC; M. Kloppenburg, MD, PhD, Department of Rheumatology, LUMC; H.K. Ronday, MD, PhD, Department of Rheumatology, Haga Hospital; A.J. Peeters, MD, PhD, Department of Rheumatology, Reinier de Graaf Gasthuis; P.J.S.M. Kerstens, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; T.W.J. Huizinga, MD, PhD, Department of Rheumatology, LUMC; W.F. Lems, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; Department of Rheumatology, VU Medical Center; C.F. Allaart, MD, PhD, Department of Rheumatology, LUMC. M. van den Broek and L. Dirven contributed equally to this report. Address correspondence to Dr. M. van den Broek, Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: m.van_den_broek@lumc.nl Accepted for publication January 25, 2013.
H. Karel Ronday
From the Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden; Department of Radiology, LUMC, Leiden; Department of Rheumatology, Haga Hospital, The Hague; Department of Rheumatology, Reinier de Graaf Gasthuis, Delft; Department of Rheumatology, Jan van Breemen Research Institute, Reade, Amsterdam; and Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands. Supported by the Dutch College of Health Insurance Companies, Janssen B.V., and Schering-Plough Ltd. M. van den Broek, MD; L. Dirven, PhD, Department of Rheumatology, LUMC; H.M. Kroon, MD, PhD, Department of Radiology, LUMC; M. Kloppenburg, MD, PhD, Department of Rheumatology, LUMC; H.K. Ronday, MD, PhD, Department of Rheumatology, Haga Hospital; A.J. Peeters, MD, PhD, Department of Rheumatology, Reinier de Graaf Gasthuis; P.J.S.M. Kerstens, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; T.W.J. Huizinga, MD, PhD, Department of Rheumatology, LUMC; W.F. Lems, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; Department of Rheumatology, VU Medical Center; C.F. Allaart, MD, PhD, Department of Rheumatology, LUMC. M. van den Broek and L. Dirven contributed equally to this report. Address correspondence to Dr. M. van den Broek, Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: m.van_den_broek@lumc.nl Accepted for publication January 25, 2013.
André J. Peeters
From the Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden; Department of Radiology, LUMC, Leiden; Department of Rheumatology, Haga Hospital, The Hague; Department of Rheumatology, Reinier de Graaf Gasthuis, Delft; Department of Rheumatology, Jan van Breemen Research Institute, Reade, Amsterdam; and Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands. Supported by the Dutch College of Health Insurance Companies, Janssen B.V., and Schering-Plough Ltd. M. van den Broek, MD; L. Dirven, PhD, Department of Rheumatology, LUMC; H.M. Kroon, MD, PhD, Department of Radiology, LUMC; M. Kloppenburg, MD, PhD, Department of Rheumatology, LUMC; H.K. Ronday, MD, PhD, Department of Rheumatology, Haga Hospital; A.J. Peeters, MD, PhD, Department of Rheumatology, Reinier de Graaf Gasthuis; P.J.S.M. Kerstens, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; T.W.J. Huizinga, MD, PhD, Department of Rheumatology, LUMC; W.F. Lems, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; Department of Rheumatology, VU Medical Center; C.F. Allaart, MD, PhD, Department of Rheumatology, LUMC. M. van den Broek and L. Dirven contributed equally to this report. Address correspondence to Dr. M. van den Broek, Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: m.van_den_broek@lumc.nl Accepted for publication January 25, 2013.
Pit J.S.M. Kerstens
From the Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden; Department of Radiology, LUMC, Leiden; Department of Rheumatology, Haga Hospital, The Hague; Department of Rheumatology, Reinier de Graaf Gasthuis, Delft; Department of Rheumatology, Jan van Breemen Research Institute, Reade, Amsterdam; and Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands. Supported by the Dutch College of Health Insurance Companies, Janssen B.V., and Schering-Plough Ltd. M. van den Broek, MD; L. Dirven, PhD, Department of Rheumatology, LUMC; H.M. Kroon, MD, PhD, Department of Radiology, LUMC; M. Kloppenburg, MD, PhD, Department of Rheumatology, LUMC; H.K. Ronday, MD, PhD, Department of Rheumatology, Haga Hospital; A.J. Peeters, MD, PhD, Department of Rheumatology, Reinier de Graaf Gasthuis; P.J.S.M. Kerstens, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; T.W.J. Huizinga, MD, PhD, Department of Rheumatology, LUMC; W.F. Lems, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; Department of Rheumatology, VU Medical Center; C.F. Allaart, MD, PhD, Department of Rheumatology, LUMC. M. van den Broek and L. Dirven contributed equally to this report. Address correspondence to Dr. M. van den Broek, Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: m.van_den_broek@lumc.nl Accepted for publication January 25, 2013.
Tom W.J. Huizinga
From the Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden; Department of Radiology, LUMC, Leiden; Department of Rheumatology, Haga Hospital, The Hague; Department of Rheumatology, Reinier de Graaf Gasthuis, Delft; Department of Rheumatology, Jan van Breemen Research Institute, Reade, Amsterdam; and Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands. Supported by the Dutch College of Health Insurance Companies, Janssen B.V., and Schering-Plough Ltd. M. van den Broek, MD; L. Dirven, PhD, Department of Rheumatology, LUMC; H.M. Kroon, MD, PhD, Department of Radiology, LUMC; M. Kloppenburg, MD, PhD, Department of Rheumatology, LUMC; H.K. Ronday, MD, PhD, Department of Rheumatology, Haga Hospital; A.J. Peeters, MD, PhD, Department of Rheumatology, Reinier de Graaf Gasthuis; P.J.S.M. Kerstens, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; T.W.J. Huizinga, MD, PhD, Department of Rheumatology, LUMC; W.F. Lems, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; Department of Rheumatology, VU Medical Center; C.F. Allaart, MD, PhD, Department of Rheumatology, LUMC. M. van den Broek and L. Dirven contributed equally to this report. Address correspondence to Dr. M. van den Broek, Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: m.van_den_broek@lumc.nl Accepted for publication January 25, 2013.
Willem F. Lems
From the Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden; Department of Radiology, LUMC, Leiden; Department of Rheumatology, Haga Hospital, The Hague; Department of Rheumatology, Reinier de Graaf Gasthuis, Delft; Department of Rheumatology, Jan van Breemen Research Institute, Reade, Amsterdam; and Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands. Supported by the Dutch College of Health Insurance Companies, Janssen B.V., and Schering-Plough Ltd. M. van den Broek, MD; L. Dirven, PhD, Department of Rheumatology, LUMC; H.M. Kroon, MD, PhD, Department of Radiology, LUMC; M. Kloppenburg, MD, PhD, Department of Rheumatology, LUMC; H.K. Ronday, MD, PhD, Department of Rheumatology, Haga Hospital; A.J. Peeters, MD, PhD, Department of Rheumatology, Reinier de Graaf Gasthuis; P.J.S.M. Kerstens, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; T.W.J. Huizinga, MD, PhD, Department of Rheumatology, LUMC; W.F. Lems, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; Department of Rheumatology, VU Medical Center; C.F. Allaart, MD, PhD, Department of Rheumatology, LUMC. M. van den Broek and L. Dirven contributed equally to this report. Address correspondence to Dr. M. van den Broek, Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: m.van_den_broek@lumc.nl Accepted for publication January 25, 2013.
Cornelia F. Allaart
From the Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden; Department of Radiology, LUMC, Leiden; Department of Rheumatology, Haga Hospital, The Hague; Department of Rheumatology, Reinier de Graaf Gasthuis, Delft; Department of Rheumatology, Jan van Breemen Research Institute, Reade, Amsterdam; and Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands. Supported by the Dutch College of Health Insurance Companies, Janssen B.V., and Schering-Plough Ltd. M. van den Broek, MD; L. Dirven, PhD, Department of Rheumatology, LUMC; H.M. Kroon, MD, PhD, Department of Radiology, LUMC; M. Kloppenburg, MD, PhD, Department of Rheumatology, LUMC; H.K. Ronday, MD, PhD, Department of Rheumatology, Haga Hospital; A.J. Peeters, MD, PhD, Department of Rheumatology, Reinier de Graaf Gasthuis; P.J.S.M. Kerstens, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; T.W.J. Huizinga, MD, PhD, Department of Rheumatology, LUMC; W.F. Lems, MD, PhD, Department of Rheumatology, Jan van Breemen Research Institute, Reade; Department of Rheumatology, VU Medical Center; C.F. Allaart, MD, PhD, Department of Rheumatology, LUMC. M. van den Broek and L. Dirven contributed equally to this report. Address correspondence to Dr. M. van den Broek, Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: m.van_den_broek@lumc.nl Accepted for publication January 25, 2013.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Early Local Swelling and Tenderness Are Associated with Large-joint Damage After 8 Years of Treatment to Target in Patients with Recent-onset Rheumatoid Arthritis
Marianne van den Broek, Linda Dirven, Herman M. Kroon, Margreet Kloppenburg, H. Karel Ronday, André J. Peeters, Pit J.S.M. Kerstens, Tom W.J. Huizinga, Willem F. Lems, Cornelia F. Allaart
The Journal of Rheumatology Apr 2013, jrheum.121248; DOI: 10.3899/jrheum.121248
Early Local Swelling and Tenderness Are Associated with Large-joint Damage After 8 Years of Treatment to Target in Patients with Recent-onset Rheumatoid Arthritis
Marianne van den Broek, Linda Dirven, Herman M. Kroon, Margreet Kloppenburg, H. Karel Ronday, André J. Peeters, Pit J.S.M. Kerstens, Tom W.J. Huizinga, Willem F. Lems, Cornelia F. Allaart
The Journal of Rheumatology Apr 2013, jrheum.121248; DOI: 10.3899/jrheum.121248