Research ArticleArticle
Major Malformations Following Exposure to Nonsteroidal Antiinflammatory Drugs During the First Trimester of Pregnancy
Sharon Daniel, Ilan Matok, Rafael Gorodischer, Gideon Koren, Elia Uziel, Arnon Wiznitzer and Amalia Levy
The Journal of Rheumatology September 2012, jrheum.120453; DOI: https://doi.org/10.3899/jrheum.120453
Sharon Daniel
From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia@bgu.ac.il Accepted for publication July 11, 2012.
Ilan Matok
From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia@bgu.ac.il Accepted for publication July 11, 2012.
Rafael Gorodischer
From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia@bgu.ac.il Accepted for publication July 11, 2012.
Gideon Koren
From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia@bgu.ac.il Accepted for publication July 11, 2012.
Elia Uziel
From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia@bgu.ac.il Accepted for publication July 11, 2012.
Arnon Wiznitzer
From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia@bgu.ac.il Accepted for publication July 11, 2012.
Amalia Levy
From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia@bgu.ac.il Accepted for publication July 11, 2012.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Major Malformations Following Exposure to Nonsteroidal Antiinflammatory Drugs During the First Trimester of Pregnancy
Sharon Daniel, Ilan Matok, Rafael Gorodischer, Gideon Koren, Elia Uziel, Arnon Wiznitzer, Amalia Levy
The Journal of Rheumatology Sep 2012, jrheum.120453; DOI: 10.3899/jrheum.120453