Major Malformations Following Exposure to Nonsteroidal Antiinflammatory Drugs During the First Trimester of Pregnancy

From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia{at}bgu.ac.il Accepted for publication July 11, 2012.

From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia{at}bgu.ac.il Accepted for publication July 11, 2012.

From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia{at}bgu.ac.il Accepted for publication July 11, 2012.

From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia{at}bgu.ac.il Accepted for publication July 11, 2012.

From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia{at}bgu.ac.il Accepted for publication July 11, 2012.

From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia{at}bgu.ac.il Accepted for publication July 11, 2012.

From the Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Soroka Medical Center, Beer Sheva, Israel; and The Hospital for Sick Children, and The University of Toronto, Toronto, Ontario, Canada. S. Daniel, MD, MPH, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben-Gurion Motherisk Obstetric Registry of Exposure collaboration (BeMORE), Ben-Gurion University of the Negev; I. Matok, MSc, Pharm, PhD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; R. Gorodischer, MD, Department of Pediatrics, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); G. Koren, MD, Motherisk Program, Division of Clinical Pharmacology-Toxicology, Hospital for Sick Children, BeMORE; E. Uziel, MSc, Social Work Services, Soroka Medical Center; A. Wiznitzer, MD, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Clalit Health Services (Southern District); A. Levy, MPH, PhD, Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, BeMORE, Ben-Gurion University of the Negev. Address correspondence to A. Levy, Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, PO Box 653, Beer-Sheva 84105, Israel. E-mail: lamalia{at}bgu.ac.il Accepted for publication July 11, 2012.