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Research ArticleArticle

Clinical Features of Late-onset Ankylosing Spondylitis: Comparison with Early-onset Disease

Carlos Montilla, Javier Del Pino-Montes, Eduardo Collantes-Estevez, Pilar Font, Pedro Zarco, Juan Mulero, Jordi Gratacós, Carlos Rodríguez, Xavier Juanola, Jose Luis Fernández-Sueiro and Raquel Almodovar
The Journal of Rheumatology March 2012, jrheum.111082; DOI: https://doi.org/10.3899/jrheum.111082
Carlos Montilla
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Javier Del Pino-Montes
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Eduardo Collantes-Estevez
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Pilar Font
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Pedro Zarco
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Juan Mulero
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Jordi Gratacós
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Carlos Rodríguez
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Xavier Juanola
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Jose Luis Fernández-Sueiro
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Raquel Almodovar
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Abstract

Objective Ankylosing spondylitis (AS) is generally observed in young patients but can occur later in life or in persons ≥ 50 years of age. Our objective was to characterize the clinical features of late-onset AS in a large multicenter national cohort.

Methods We studied late-onset AS in the National Registry of Spondyloarthritis of the Spanish Society of Rheumatology (REGISPONSER database) cohort (n = 1257), of whom 3.5% had onset at age ≥ 50 years versus a control group with onset at < 50 years.

Results There were no differences between late-onset and early-onset AS according to sex and family history of spondyloarthropathies. Patients in the late-onset group more often showed involvement of the cervical spine (22.7% vs 9.7%; p = 0.03) and arthritis of the upper (13.6% vs 3.0%; p = 0.002) and lower limbs (27.3% vs 15.2%; p = 0.03) as first manifestations than did patients in the early-onset group. A higher percentage of mixed forms (axial and peripheral joint disease) during the course of the disease was also recorded in the late-onset group (50% vs 24%; p = 0.0001).

Conclusion Our study suggests that age at onset of AS affects the patients’ presenting clinical form. Arthritis of the upper limbs requires a differential diagnosis with other conditions frequent in patients over 50 years of age, such as rheumatoid arthritis or crystal-induced arthropathy.

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The Journal of Rheumatology
Vol. 50, Issue 1
1 Jan 2023
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Clinical Features of Late-onset Ankylosing Spondylitis: Comparison with Early-onset Disease
Carlos Montilla, Javier Del Pino-Montes, Eduardo Collantes-Estevez, Pilar Font, Pedro Zarco, Juan Mulero, Jordi Gratacós, Carlos Rodríguez, Xavier Juanola, Jose Luis Fernández-Sueiro, Raquel Almodovar
The Journal of Rheumatology Mar 2012, jrheum.111082; DOI: 10.3899/jrheum.111082

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Clinical Features of Late-onset Ankylosing Spondylitis: Comparison with Early-onset Disease
Carlos Montilla, Javier Del Pino-Montes, Eduardo Collantes-Estevez, Pilar Font, Pedro Zarco, Juan Mulero, Jordi Gratacós, Carlos Rodríguez, Xavier Juanola, Jose Luis Fernández-Sueiro, Raquel Almodovar
The Journal of Rheumatology Mar 2012, jrheum.111082; DOI: 10.3899/jrheum.111082
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