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Research ArticleArticle

Association Between Depression and Vascular Disease in Systemic Lupus Erythematosus

Carol M. Greco, Tracy Li, Abdus Sattar, Amy H. Kao, Natalya Danchenko, Daniel Edmundowicz, Kim Sutton-Tyrrell, Russell P. Tracy, Lewis H. Kuller and Susan Manzi
The Journal of Rheumatology December 2011, jrheum.110327; DOI: https://doi.org/10.3899/jrheum.110327
Carol M. Greco
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Tracy Li
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Abdus Sattar
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Amy H. Kao
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Natalya Danchenko
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Daniel Edmundowicz
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Kim Sutton-Tyrrell
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Russell P. Tracy
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Lewis H. Kuller
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Susan Manzi
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Abstract

Objective Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with increased prevalence of cardiovascular disease (CVD) and depression. Although depression may contribute to CVD risk in population-based studies, its influence on cardiovascular morbidity in SLE has not been evaluated. We evaluated the association between depression and vascular disease in SLE.

Methods A cross-sectional study was conducted from 2002-2005 in 161 women with SLE and without CVD. The primary outcome measure was a composite vascular disease marker consisting of the presence of coronary artery calcium and/or carotid artery plaque.

Results In total, 101 women met criteria for vascular disease. In unadjusted analyses, several traditional cardiovascular risk factors, inflammatory markers, adiposity, SLE disease-related factors, and depression were associated with vascular disease. In the final multivariable model, the psychological variable depression was associated with nearly 4-fold higher odds for vascular disease (OR 3.85, 95% CI 1.37, 10.87) when adjusted for other risk factors of age, lower education level, hypertensive status, waist-hip ratio, and C-reactive protein.

Conclusion In SLE, depression is independently associated with vascular disease, along with physical factors.

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The Journal of Rheumatology
Vol. 52, Issue 5
1 May 2025
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Association Between Depression and Vascular Disease in Systemic Lupus Erythematosus
Carol M. Greco, Tracy Li, Abdus Sattar, Amy H. Kao, Natalya Danchenko, Daniel Edmundowicz, Kim Sutton-Tyrrell, Russell P. Tracy, Lewis H. Kuller, Susan Manzi
The Journal of Rheumatology Dec 2011, jrheum.110327; DOI: 10.3899/jrheum.110327

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Association Between Depression and Vascular Disease in Systemic Lupus Erythematosus
Carol M. Greco, Tracy Li, Abdus Sattar, Amy H. Kao, Natalya Danchenko, Daniel Edmundowicz, Kim Sutton-Tyrrell, Russell P. Tracy, Lewis H. Kuller, Susan Manzi
The Journal of Rheumatology Dec 2011, jrheum.110327; DOI: 10.3899/jrheum.110327
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