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Research ArticleArticle

25-Hydroxyvitamin D Levels and Vitamin D Deficiency in Children with Rheumatologic Disorders and Controls

Christina F. Pelajo, Jorge M. Lopez-Benitez and Laurie C. Miller
The Journal of Rheumatology July 2011, jrheum.110123; DOI: https://doi.org/10.3899/jrheum.110123
Christina F. Pelajo
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Jorge M. Lopez-Benitez
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Laurie C. Miller
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Abstract

Objective To evaluate the prevalence of vitamin D deficiency, as well as factors associated with serum 25-hydroxyvitamin D [25(OH)D] levels, in children attending a pediatric rheumatology clinic, and to determine whether there was a difference in serum 25(OH)D levels and in vitamin D deficiency between children with autoimmune disorders and nonautoimmune conditions.

Methods Cross-sectional analysis of serum 25(OH)D levels of patients between the ages of 2 and 19 years, seen between November 2008 and October 2009.

Results A total of 254 patients were studied (169 autoimmune disorders, 85 nonautoimmune conditions). The mean age of study patients was 12.3 years; 67% were female and 80% were white. In the autoimmune disorders group, 23% had vitamin D deficiency [serum 25(OH)D < 20 ng/ml], and in the nonautoimmune conditions group 14% were vitamin D deficient. The average level of serum 25(OH)D was 28.6 (± 11) ng/ml (range 2 to 59). Age, ethnicity, body mass index, use of supplements, and season were significantly associated with serum levels of 25(OH)D (all p ≤ 0.02). The OR of patients with autoimmune disorders being vitamin D deficient was 2.3, in relation to patients with nonautoimmune conditions (p = 0.04).

Conclusion Twenty percent of patients attending a pediatric rheumatology clinic were vitamin D deficient. Patients with autoimmune disorders were more likely to be vitamin D deficient than patients with nonautoimmune conditions. Screening of serum 25(OH)D levels should be performed for patients with autoimmune disorders.

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The Journal of Rheumatology
Vol. 52, Issue 6
1 Jun 2025
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25-Hydroxyvitamin D Levels and Vitamin D Deficiency in Children with Rheumatologic Disorders and Controls
Christina F. Pelajo, Jorge M. Lopez-Benitez, Laurie C. Miller
The Journal of Rheumatology Jul 2011, jrheum.110123; DOI: 10.3899/jrheum.110123

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25-Hydroxyvitamin D Levels and Vitamin D Deficiency in Children with Rheumatologic Disorders and Controls
Christina F. Pelajo, Jorge M. Lopez-Benitez, Laurie C. Miller
The Journal of Rheumatology Jul 2011, jrheum.110123; DOI: 10.3899/jrheum.110123
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