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Research ArticleArticle

The Longitudinal Outcome of Fibromyalgia: A Study of 1555 Patients

Brian Walitt, Mary-Ann Fitzcharles, Afton L. Hassett, Robert S. Katz, Winfried Häuser and Frederick Wolfe
The Journal of Rheumatology July 2011, jrheum.110026; DOI: https://doi.org/10.3899/jrheum.110026
Brian Walitt
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Mary-Ann Fitzcharles
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Afton L. Hassett
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Robert S. Katz
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Winfried Häuser
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Frederick Wolfe
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Abstract

Objective To describe the diagnosis status and outcome of patients diagnosed with fibromyalgia (FM) by US rheumatologists.

Methods We assessed 1555 patients with FM with detailed outcome questionnaires during 11,006 semiannual observations for up to 11 years. At entry, all patients satisfied American College of Rheumatology preliminary 2010 FM criteria modified for survey research. We determined diagnosis status, rates of improvement, responder subgroups, and standardized mean differences (effect sizes) between start and study completion scores of global well-being, pain, sleep problems, and health related quality of life. (QOL)

Results The 5-year improvement rates were pain 0.4 (95% CI 0.2, 0.5), fatigue 0.4 (95% CI 0.2, 0.05), and global 0.0 (95% CI –0.1, 0.1). The standardized mean differences were patient global 0.03 (95% CI –0.02, 0.08), pain 0.22 (95% CI 0.16, 0.28), sleep problems 0.20 (95% CI 0.14, 0.25), physical component summary of the Short-form 36 (SF-36) 0.11 (95% CI –0.14, –0.07), and SF-36 mental component summary 0.03 (95% CI –0.07, 0.02). Patients switched between criteria-positive and criteria-negative states, with 716 patients (44.0%) failing to meet criteria at least once during 4228.5 patient-years (7448 observations). About 10% of patients had substantial improvement and about 15% had moderate improvement of pain. Overall, FM severity worsened in 35.9% and pain in 38.6%.

Conclusion Although we found no average clinically meaningful improvement in symptom severity overall, 25% had at least moderate improvement of pain over time. The result that emerged from this longitudinal study was one of generally continuing high levels of self-reported symptoms and distress for most patients, but a slight trend toward improvement.

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The Journal of Rheumatology
Vol. 50, Issue 4
1 Apr 2023
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The Longitudinal Outcome of Fibromyalgia: A Study of 1555 Patients
Brian Walitt, Mary-Ann Fitzcharles, Afton L. Hassett, Robert S. Katz, Winfried Häuser, Frederick Wolfe
The Journal of Rheumatology Jul 2011, jrheum.110026; DOI: 10.3899/jrheum.110026

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The Longitudinal Outcome of Fibromyalgia: A Study of 1555 Patients
Brian Walitt, Mary-Ann Fitzcharles, Afton L. Hassett, Robert S. Katz, Winfried Häuser, Frederick Wolfe
The Journal of Rheumatology Jul 2011, jrheum.110026; DOI: 10.3899/jrheum.110026
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