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Research ArticleArticle
Open Access

Rapid Improvement in the Signs and Symptoms of Rheumatoid Arthritis Following Certolizumab Pegol Treatment Predicts Better Longterm Outcomes: Post-hoc Analysis of a Randomized Controlled Trial

Edward C. Keystone, Jeffrey R. Curtis, Roy M. Fleischmann, Daniel E. Furst, Dinesh Khanna, Josef S. Smolen, Philip J. Mease, Michael H. Schiff, Geoffroy Coteur, Owen Davies and Bernard Combe
The Journal of Rheumatology March 2011, jrheum.100935; DOI: https://doi.org/10.3899/jrheum.100935
Edward C. Keystone
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Jeffrey R. Curtis
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Roy M. Fleischmann
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Daniel E. Furst
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Dinesh Khanna
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Josef S. Smolen
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Philip J. Mease
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Michael H. Schiff
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Geoffroy Coteur
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Owen Davies
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Bernard Combe
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Article Information

jrheum.100935
DOI 
https://doi.org/10.3899/jrheum.100935
PubMed 
21362764

Published By 
The Journal of Rheumatology
Print ISSN 
0315-162X
Online ISSN 
1499-2752
History 
  • Published online March 1, 2011.

Article Versions

  • You are currently viewing a Latest version of this article (March 1, 2011 - 04:00).
  • View the most recent version of this article
Copyright & Usage 
© 2011 The Journal of Rheumatology

Author Information

  1. Edward C. Keystone,
  2. Jeffrey R. Curtis,
  3. Roy M. Fleischmann,
  4. Daniel E. Furst,
  5. Dinesh Khanna,
  6. Josef S. Smolen,
  7. Philip J. Mease,
  8. Michael H. Schiff,
  9. Geoffroy Coteur,
  10. Owen Davies and
  11. Bernard Combe
  1. From the Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, Alabama, USA; Metroplex Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA; Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, and 2nd Department of Medicine, Hietzing Hospital, Vienna, Austria; Seattle Rheumatology Associates, Swedish Medical Center and University of Washington School of Medicine, Seattle, Washington, USA; Rheumatology Division, University of Colorado School of Medicine, Denver, Colorado, USA; UCB S.A., Brussels, Belgium; and Departement de Rhumatologie, Hopital Lapeyronie, Université Montpellier 1, Montpellier, France.
    UCB sponsored the clinical trial from which these post-hoc analyses were performed. Dr. Keystone has grant/research support from Abbott, Amgen, AstraZeneca, BMS, Centocor, Hoffmann-Roche, Novartis, Schering- Plough, UCB, Wyeth; consultancy fees from Abbot, Amgen, BMS, Centocor, Genentech Hoffmann-Roche, Pfizer, Schering-Plough, and UCB; Dr. Curtis has grant/research support and consultancy fees from Amgen, Centocor, Corrona, Novartis, Roche, and UCB. Dr. Fleischmann has grants/research support from Amgen, Wyeth, Centocor, Abbott, Genentech, Biogen Idec, Roche, UCB, Regeneron, Lilly, Pfizer, BMS; consultancy fees from Amgen, Wyeth, Centocor, Abbott, Genentech, Biogen Idec, UCB, AstraZeneca, Pfizer, BMS, Roche, Lilly, Schering Plough, and GSK. Dr. Mease has grants/research support, consultancy fees, and honoraria from Abbott, Amgen, Biogen Idec, BMS, Centocor, Genentech, Lilly, Pfizer, Roche, Schering-Plough, Wyeth, and UCB. Dr. Khanna has grant/research support from Actelion, Gilead, Takeda, Savient, NIH; consultancy fees from Actelion, Fibrogen, MediQuest, Takeda, Savient, and UCB. Dr. Smolen has grant/research support and consultancy fees from UCB. Dr. Furst has grant/research support from Abbott, Actelion, Amgen, BMS, Genentech, Gilead, GSK, Nitec, Norvatis, Roche, UCB, Wyeth, Xoma; consultancy fees from Abbott, Actelion, Amgen, Biogen Idec, BMS, Centocor, Genentech, Gilead, Merck, Nitec, Novartis, UCB, Wyeth, Xoma; honoraria: Abbott, Actelion, Amgen, Biogen Idec, BMS, Centocor, Genentech, Gilead, GSK, Nitec, and Dr. Schiff has grant/research support and consultancy fees from UCB. Dr. Coteur and Dr. Davies are employed by UCB. Dr. Combe has grants/research support from UCB, MSD, Pfizer, Roche, Schering; consultancy fees from UCB, Abbott, GSK, MSD, Pfizer, Roche, and Schering.
    E.C. Keystone, MD, FRCPC, Professor of Medicine, University of Toronto; J.R. Curtis, MD, Associate Professor of Medicine, University of Alabama; R.M. Fleischmann, MD, Clinical Professor in Internal Medicine, University of Texas Southwestern Medical Center; P.J. Mease, MD, Chief of Rheumatology Research and Clinical Professor of Medicine, University of Washington School of Medicine; D. Khanna, MD, Associate Professor of Medicine, David Geffen School of Medicine, University of California Los Angeles; J. Smolen MD, Professor, Chairman of Rheumatology, Medical University of Vienna; D.E. Furst, MD, Carl M. Pearson Professor of Rheumatology, David Geffen School of Medicine, University of California Los Angeles; M.H. Schiff, MD, Clinical Professor of Medicine, University of Colorado School of Medicine; G. Coteur, PhD, UCB S.A.; O. Davies, PhD, UCB S.A.; B. Combe, MD, PhD, Professor of Rheumatology, Université Montpellier 1.
    Address correspondence to Dr. E.C. Keystone, Mount Sinai Hospital, Joseph and Wolf Lebovic Building, Second Floor, Room 2-006, 60 Murray Street, Toronto, Ontario M5G 1X5. E-mail: edkeystone@mtsinai.on.ca
    Full Release Article. For details see Reprints/Permissions at jrheum.org
    Accepted for publication January 11, 2011.

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Rapid Improvement in the Signs and Symptoms of Rheumatoid Arthritis Following Certolizumab Pegol Treatment Predicts Better Longterm Outcomes: Post-hoc Analysis of a Randomized Controlled Trial
Edward C. Keystone, Jeffrey R. Curtis, Roy M. Fleischmann, Daniel E. Furst, Dinesh Khanna, Josef S. Smolen, Philip J. Mease, Michael H. Schiff, Geoffroy Coteur, Owen Davies, Bernard Combe
The Journal of Rheumatology Mar 2011, jrheum.100935; DOI: 10.3899/jrheum.100935

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Rapid Improvement in the Signs and Symptoms of Rheumatoid Arthritis Following Certolizumab Pegol Treatment Predicts Better Longterm Outcomes: Post-hoc Analysis of a Randomized Controlled Trial
Edward C. Keystone, Jeffrey R. Curtis, Roy M. Fleischmann, Daniel E. Furst, Dinesh Khanna, Josef S. Smolen, Philip J. Mease, Michael H. Schiff, Geoffroy Coteur, Owen Davies, Bernard Combe
The Journal of Rheumatology Mar 2011, jrheum.100935; DOI: 10.3899/jrheum.100935
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