Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • GDPR Policy
    • Accessibility
  • Contact Us
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on RSS
Research ArticleArticle

Determinants of Early Radiographic Progression in Ankylosing Spondylitis

Pamir Atagunduz, Sibel Zehra Aydin, Cengiz Bahadir, Burak Erer and Haner Direskeneli
The Journal of Rheumatology September 2010, jrheum.100094; DOI: https://doi.org/10.3899/jrheum.100094
Pamir Atagunduz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sibel Zehra Aydin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cengiz Bahadir
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Burak Erer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Haner Direskeneli
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • References
  • Info & Metrics
  • PDF
  • eLetters
Next
Loading

Abstract

Objective To investigate the demographic and clinical characteristics associated with early, extensive radiographic changes in ankylosing spondylitis (AS).

Methods Radiographic severity was assessed cross-sectionally in 235 patients with AS using the Bath AS Radiological Index spine score (BASRI-s). Patients with extensive radiographic changes on the lumbar portion of BASRI-s were defined as the early axial ankylosis (EAA) Group. ANCOVA and logistic regression analyses were used to identify factors affecting EAA.

Results Most study patients were men (139/235, 59.0%). Mean disease duration was 12.4 ± 9.3 years. Fifteen percent of women and 34.8% of men with AS were in the EAA group. HLA-B27-positive men with AS had significantly higher BASRI-lumbar scores, while HLA-B27 had no effect on radiographic progression of axial disease in women with AS. Peripheral joint involvement was associated with slow radiographic progression. Hip involvement had no effect on axial progression but uveitis was more frequent in the male EAA group. The odds for an HLA-B27-positive male patient with AS who did not have peripheral arthritis of having a BASRI-lumbar score of 3 or higher were 3.4 (77% chance to have axially progressive disease). Presence of uveitis increased these odds to 93%. Only 15% of female patients with AS had EAA, and the absence of peripheral arthritis was the only clinical measure associated with EAA in this group.

Conclusion EAA was more frequent in men with AS than in women. Absence of peripheral arthritis, HLA-B27 positivity, and uveitis were associated with multiple syndesmophytes or fusion of multiple vertebrae of the lumbar vertebrae.

    Next
    Back to top

    In this issue

    The Journal of Rheumatology
    Vol. 48, Issue 2
    1 Feb 2021
    • Table of Contents
    • Table of Contents (PDF)
    • Index by Author
    Download PDF
    Article Alerts
    Sign In to Email Alerts with your Email Address
    Email Article

    Thank you for your interest in spreading the word about The Journal of Rheumatology.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Determinants of Early Radiographic Progression in Ankylosing Spondylitis
    (Your Name) has forwarded a page to you from The Journal of Rheumatology
    (Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Citation Tools
    Determinants of Early Radiographic Progression in Ankylosing Spondylitis
    Pamir Atagunduz, Sibel Zehra Aydin, Cengiz Bahadir, Burak Erer, Haner Direskeneli
    The Journal of Rheumatology Sep 2010, jrheum.100094; DOI: 10.3899/jrheum.100094

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero

     Request Permissions

    Share
    Determinants of Early Radiographic Progression in Ankylosing Spondylitis
    Pamir Atagunduz, Sibel Zehra Aydin, Cengiz Bahadir, Burak Erer, Haner Direskeneli
    The Journal of Rheumatology Sep 2010, jrheum.100094; DOI: 10.3899/jrheum.100094
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    • Tweet Widget
    • Facebook Like
    • Google Plus One
    Save to my folders

    Jump to section

    • Article
    • References
    • Info & Metrics
    • PDF
    • eLetters

    Related Articles

    Cited By...

    More in this TOC Section

    • Salivary Gland Focus Score Is Associated With Myocardial Fibrosis in Primary Sjögren Syndrome Assessed by a Cardiac Magnetic Resonance Approach
    • Hydroxychloroquine Suppresses Interferon-inducible Genes and B Cell Activating Factor in Patients With Incomplete and New-onset Systemic Lupus Erythematosus
    • The Prevalence of Rheumatoid Arthritis: A Systematic Review of Population-based Studies
    Show more Articles

    Similar Articles

    Content

    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology

    Resources

    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies

    Subscribers

    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions

    More

    • About Us
    • Contact Us
    • My Alerts
    • My Folders
    • RSS Feeds
    The Journal of Rheumatology
    The content of this site is intended for health care professionals.
    Copyright © 2016 by The Journal of Rheumatology Publishing Co. Ltd.
    Print ISSN: 0315-162X; Online ISSN: 1499-2752
    Powered by HighWire