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Research ArticleArticle

Methotrexate in Psoriasis and Psoriatic Arthritis

Laura C. Coates, Joseph F. Merola, Suzanne M. Grieb, Philip J. Mease and Kristina Callis Duffin
The Journal of Rheumatology Supplement June 2020, 96 31-35; DOI: https://doi.org/10.3899/jrheum.200124
Laura C. Coates
From the Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Department of Dermatology and Medicine, Division of Rheumatology, Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts; Department of Pediatrics, Research Associate, Johns Hopkins University School of Medicine, Baltimore, Maryland; Rheumatology Research, Swedish Medical Center/Providence St. Joseph Health and University of Washington School of Medicine, Seattle, Washington; Department of Dermatology, University of Utah, Salt Lake City, Utah, USA.
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  • For correspondence: laura.coates@ndorms.ox.ac.uk
Joseph F. Merola
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Suzanne M. Grieb
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Philip J. Mease
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Kristina Callis Duffin
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Abstract

Methotrexate (MTX) is the most commonly prescribed first-line therapy in psoriatic arthritis (PsA) internationally and is also commonly used in the treatment of psoriasis. However, data supporting its use in PsA are limited and significant toxicities can occur. This article summarizes a debate at the 2019 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) annual meeting that focused on the use of MTX in psoriasis and PsA. Four clinicians and 1 patient research partner presented clinical study data and the patient experience summarizing the efficacy, tolerability, and toxicity of MTX for both skin and musculoskeletal manifestations. A survey of attending GRAPPA members collected data on current and planned future use of MTX across the world.

Key Indexing Terms:
  • PSORIASIS
  • PSORIATIC ARTHRITIS
  • METHOTREXATE GRAPPA
  • PATIENT RESEARCH PARTNERS
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The Journal of Rheumatology Supplement
Vol. 96
1 Jun 2020
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Methotrexate in Psoriasis and Psoriatic Arthritis
Laura C. Coates, Joseph F. Merola, Suzanne M. Grieb, Philip J. Mease, Kristina Callis Duffin
The Journal of Rheumatology Supplement Jun 2020, 96 31-35; DOI: 10.3899/jrheum.200124

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Methotrexate in Psoriasis and Psoriatic Arthritis
Laura C. Coates, Joseph F. Merola, Suzanne M. Grieb, Philip J. Mease, Kristina Callis Duffin
The Journal of Rheumatology Supplement Jun 2020, 96 31-35; DOI: 10.3899/jrheum.200124
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Keywords

PSORIASIS
PSORIATIC ARTHRITIS
METHOTREXATE GRAPPA
PATIENT RESEARCH PARTNERS

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Keywords

  • psoriasis
  • psoriatic arthritis
  • METHOTREXATE GRAPPA
  • PATIENT RESEARCH PARTNERS

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