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Research ArticleArticle

Moving Toward Precision Medicine in Psoriasis and Psoriatic Arthritis

Christopher T. Ritchlin, Stephen R. Pennington, Nick J. Reynolds and Oliver FitzGerald
The Journal of Rheumatology Supplement June 2020, 96 19-24; DOI: https://doi.org/10.3899/jrheum.200122
Christopher T. Ritchlin
From the Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, New York, USA; School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD), Dublin, Ireland; Institute of Translational and Clinical Medicine, Newcastle University and Newcastle Dermatology, Newcastle Hospitals National Health Service (NHS) Foundation Trust, Newcastle upon Tyne, UK; Department of Rheumatology, St. Vincent’s University Hospital, Dublin, Ireland.
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Stephen R. Pennington
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Nick J. Reynolds
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Oliver FitzGerald
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Abstract

Current management approaches for the treatment of psoriasis and psoriatic arthritis (PsA) are imprecise and depend largely on clinical assessment. A more precise approach, which takes into account an individual patient’s variations in genes, proteins, environment, and lifestyle, is beginning to receive attention with the most advanced progress seen in the treatment of cancer. Herein, the methodological approaches required for this precision medicine approach to be adopted in psoriatic disease, as well as their advantages, are reviewed. In addition, advances that are being made to address areas of unmet need in PsA, notably the use of proteomic approaches, are presented with suggestions that combine genetic and protein data (proteogenomics). Finally, progress that is being made in 2 large-scale, multipartner studies focused on the development of a precision medicine approach to the treatment of skin psoriasis is presented and discussed.

Key Indexing Terms:
  • PSORIATIC ARTHRITIS
  • PSORIASIS
  • PRECISION MEDICINE
  • GRAPPA
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The Journal of Rheumatology Supplement
Vol. 96
1 Jun 2020
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Moving Toward Precision Medicine in Psoriasis and Psoriatic Arthritis
Christopher T. Ritchlin, Stephen R. Pennington, Nick J. Reynolds, Oliver FitzGerald
The Journal of Rheumatology Supplement Jun 2020, 96 19-24; DOI: 10.3899/jrheum.200122

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Moving Toward Precision Medicine in Psoriasis and Psoriatic Arthritis
Christopher T. Ritchlin, Stephen R. Pennington, Nick J. Reynolds, Oliver FitzGerald
The Journal of Rheumatology Supplement Jun 2020, 96 19-24; DOI: 10.3899/jrheum.200122
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Keywords

PSORIATIC ARTHRITIS
PSORIASIS
PRECISION MEDICINE
GRAPPA

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Keywords

  • psoriatic arthritis
  • psoriasis
  • PRECISION MEDICINE
  • GRAPPA

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