The Role of the Pulmonary Microenvironment in Driving Transition From Systemic Sclerosis to Systemic Sclerosis–Associated Interstitial Lung Disease

Rosa I. Rodríguez Viera; Julia Malitska; Susan Sultani; Nazia Chaudhuri; Guillermo Lopez-Campos; Koray N. Potel; Steven O’Reilly; Bettina C. Schock

doi:10.3899/jrheum.2025-0322

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The Role of the Pulmonary Microenvironment in Driving Transition From Systemic Sclerosis to Systemic Sclerosis–Associated Interstitial Lung Disease

Rosa I. Rodríguez Viera, Julia Malitska, Susan Sultani, Nazia Chaudhuri, Guillermo Lopez-Campos, Koray N. Potel, Steven O’Reilly and Bettina C. Schock

The Journal of Rheumatology June 2026, 53 (6) 592-602; DOI: https://doi.org/10.3899/jrheum.2025-0322

Rosa I. Rodríguez Viera

1R.I. Rodríguez Viera, MD, Welcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, UK, and University of Las Palmas de Gran Canaria, Gran Canaria, Spain;

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Julia Malitska

2J. Malitska, Welcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, UK, and Educational and Scientific Center “Institute of Biology and Medicine,” Taras Shevchenko National University of Kyiv, Kyiv, Ukraine;

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Susan Sultani

3S. Sultani, Welcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, UK, and Al Farabi Kazakh National University, Almaty, Kazakhstan;

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Nazia Chaudhuri

4N. Chaudhuri, MB ChB, PhD, School of Medicine, Department of Life and Health Sciences, Ulster University, and Altnagelvin Area Hospital, Derry/Londonderry, UK;

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Guillermo Lopez-Campos

5G. Lopez-Campos, PhD, B.C. Schock, PhD, Welcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, UK;

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Koray N. Potel

6K.N. Potel, MB BCh BAO, Welcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, UK, and Department of Surgery, University of Minnesota, Minnesota, USA;

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Steven O’Reilly

7S. O’Reilly, BSc PhD, Department of Biosciences, Durham University, Durham, UK.

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Bettina C. Schock

5G. Lopez-Campos, PhD, B.C. Schock, PhD, Welcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, UK;

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For correspondence: b.schock{at}qub.ac.uk

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The Journal of Rheumatology

Vol. 53, Issue 6

1 Jun 2026

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The Role of the Pulmonary Microenvironment in Driving Transition From Systemic Sclerosis to Systemic Sclerosis–Associated Interstitial Lung Disease