Quality of Life in Adult Patients With SAPHO Syndrome and Chronic Nonbacterial Osteomyelitis, and Comparison to Chronic Rheumatic and Inflammatory Diseases

Aleksander Lenert; Jenna Thomason; Melanie H. Smith; Helena Abodeely; Sandy D. Hong; Courtney E. Kremer; Petar S. Lenert; T. Shawn Sato; Sandra Hansmann; Melissa Oliver; Yongdong (Dan) Zhao; Jonathan Templin; Mary Vaughan-Sarrazin; Robyn Domsic; Daniel H. Solomon; Polly J. Ferguson

doi:10.3899/jrheum.2025-0414

Research ArticleSAPHO Syndrome

Quality of Life in Adult Patients With SAPHO Syndrome and Chronic Nonbacterial Osteomyelitis, and Comparison to Chronic Rheumatic and Inflammatory Diseases

Aleksander Lenert, Jenna Thomason, Melanie H. Smith, Helena Abodeely, Sandy D. Hong, Courtney E. Kremer, Petar S. Lenert, T. Shawn Sato, Sandra Hansmann, Melissa Oliver, Yongdong (Dan) Zhao, Jonathan Templin, Mary Vaughan-Sarrazin, Robyn Domsic, Daniel H. Solomon and Polly J. Ferguson

The Journal of Rheumatology October 2025, 52 (10) 1034-1042; DOI: https://doi.org/10.3899/jrheum.2025-0414

Aleksander Lenert

1A. Lenert, MD, MS, H. Abodeely, P.S. Lenert, MD, PhD, Division of Immunology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA;

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For correspondence: aleksander-lenert{at}uiowa.edu

Jenna Thomason

2J. Thomason, MD, MPH, Division of Rheumatology, University of Washington, Rheumatology Clinic at Harborview, Seattle, Washington, USA;

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Melanie H. Smith

3M.H. Smith, MD, PhD, Weill Cornell Medicine, Hospital for Special Surgery, New York, New York, USA;

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Helena Abodeely

1A. Lenert, MD, MS, H. Abodeely, P.S. Lenert, MD, PhD, Division of Immunology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA;

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Sandy D. Hong

4S.D. Hong, MD, C.E. Kremer, ARNP, Division of Pediatric Rheumatology, University of Iowa Stead Family Children’s Hospital, Iowa City, Iowa, USA;

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Courtney E. Kremer

4S.D. Hong, MD, C.E. Kremer, ARNP, Division of Pediatric Rheumatology, University of Iowa Stead Family Children’s Hospital, Iowa City, Iowa, USA;

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Petar S. Lenert

1A. Lenert, MD, MS, H. Abodeely, P.S. Lenert, MD, PhD, Division of Immunology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA;

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T. Shawn Sato

5T.S. Sato, MD, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA;

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Sandra Hansmann

6S. Hansmann, MD, Department of Pediatrics, Division of Pediatric Rheumatology and autoinflammation reference center Tübingen (arcT), University Hospital Tübingen, Tübingen, Germany;

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Melissa Oliver

7M. Oliver, MD, Division of Pediatric Rheumatology, Indiana University School of Medicine, Indianapolis, Indiana, USA;

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Yongdong (Dan) Zhao

8Y. Zhao, MD, PhD, Division of Pediatric Rheumatology, Department of Pediatrics, University of Washington School of Medicine, Seattle Children’s Hospital, Seattle, Washington, USA;

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Jonathan Templin

9J. Templin, PhD, Department of Psychological and Quantitative Foundations, College of Education, University of Iowa, Iowa City, Iowa, USA;

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Mary Vaughan-Sarrazin

10M. Vaughan-Sarrazin, PhD, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA;

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Robyn Domsic

11R. Domsic, MD, MPH, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;

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Daniel H. Solomon

12D.H. Solomon, MD, MPH, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA;

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Polly J. Ferguson

13P.J. Ferguson, MD, Division of Pediatric Rheumatology, Carver College of Medicine, University of Iowa Stead Family Children’s Hospital, Iowa City, Iowa, USA.

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Quality of Life in Adult Patients With SAPHO Syndrome and Chronic Nonbacterial Osteomyelitis, and Comparison to Chronic Rheumatic and Inflammatory Diseases

The Journal of Rheumatology Oct 2025, 52 (10) 1034-1042; DOI: 10.3899/jrheum.2025-0414

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Quality of Life in Adult Patients With SAPHO Syndrome and Chronic Nonbacterial Osteomyelitis, and Comparison to Chronic Rheumatic and Inflammatory Diseases