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Research ArticleSAPHO Syndrome

Quality of Life in Adult Patients With SAPHO Syndrome and Chronic Nonbacterial Osteomyelitis, and Comparison to Chronic Rheumatic and Inflammatory Diseases

Aleksander Lenert, Jenna Thomason, Melanie H. Smith, Helena Abodeely, Sandy D. Hong, Courtney E. Kremer, Petar S. Lenert, T. Shawn Sato, Sandra Hansmann, Melissa Oliver, Yongdong (Dan) Zhao, Jonathan Templin, Mary Vaughan-Sarrazin, Robyn Domsic, Daniel H. Solomon and Polly J. Ferguson
The Journal of Rheumatology October 2025, 52 (10) 1034-1042; DOI: https://doi.org/10.3899/jrheum.2025-0414
Aleksander Lenert
1A. Lenert, MD, MS, H. Abodeely, P.S. Lenert, MD, PhD, Division of Immunology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA;
  • Find this author on Google Scholar
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  • ORCID record for Aleksander Lenert
  • For correspondence: aleksander-lenert{at}uiowa.edu
Jenna Thomason
2J. Thomason, MD, MPH, Division of Rheumatology, University of Washington, Rheumatology Clinic at Harborview, Seattle, Washington, USA;
  • Find this author on Google Scholar
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  • Search for this author on this site
  • ORCID record for Jenna Thomason
Melanie H. Smith
3M.H. Smith, MD, PhD, Weill Cornell Medicine, Hospital for Special Surgery, New York, New York, USA;
  • Find this author on Google Scholar
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  • ORCID record for Melanie H. Smith
Helena Abodeely
1A. Lenert, MD, MS, H. Abodeely, P.S. Lenert, MD, PhD, Division of Immunology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA;
  • Find this author on Google Scholar
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Sandy D. Hong
4S.D. Hong, MD, C.E. Kremer, ARNP, Division of Pediatric Rheumatology, University of Iowa Stead Family Children’s Hospital, Iowa City, Iowa, USA;
  • Find this author on Google Scholar
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  • ORCID record for Sandy D. Hong
Courtney E. Kremer
4S.D. Hong, MD, C.E. Kremer, ARNP, Division of Pediatric Rheumatology, University of Iowa Stead Family Children’s Hospital, Iowa City, Iowa, USA;
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Petar S. Lenert
1A. Lenert, MD, MS, H. Abodeely, P.S. Lenert, MD, PhD, Division of Immunology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA;
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  • ORCID record for Petar S. Lenert
T. Shawn Sato
5T.S. Sato, MD, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA;
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  • ORCID record for T. Shawn Sato
Sandra Hansmann
6S. Hansmann, MD, Department of Pediatrics, Division of Pediatric Rheumatology and autoinflammation reference center Tübingen (arcT), University Hospital Tübingen, Tübingen, Germany;
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Melissa Oliver
7M. Oliver, MD, Division of Pediatric Rheumatology, Indiana University School of Medicine, Indianapolis, Indiana, USA;
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  • ORCID record for Melissa Oliver
Yongdong (Dan) Zhao
8Y. Zhao, MD, PhD, Division of Pediatric Rheumatology, Department of Pediatrics, University of Washington School of Medicine, Seattle Children’s Hospital, Seattle, Washington, USA;
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  • ORCID record for Yongdong (Dan) Zhao
Jonathan Templin
9J. Templin, PhD, Department of Psychological and Quantitative Foundations, College of Education, University of Iowa, Iowa City, Iowa, USA;
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  • ORCID record for Jonathan Templin
Mary Vaughan-Sarrazin
10M. Vaughan-Sarrazin, PhD, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA;
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  • ORCID record for Mary Vaughan-Sarrazin
Robyn Domsic
11R. Domsic, MD, MPH, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;
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  • ORCID record for Robyn Domsic
Daniel H. Solomon
12D.H. Solomon, MD, MPH, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA;
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Polly J. Ferguson
13P.J. Ferguson, MD, Division of Pediatric Rheumatology, Carver College of Medicine, University of Iowa Stead Family Children’s Hospital, Iowa City, Iowa, USA.
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Article Information

vol. 52 no. 10 1034-1042
DOI 
https://doi.org/10.3899/jrheum.2025-0414
PubMed 
40750318

Published By 
The Journal of Rheumatology
Print ISSN 
0315-162X
Online ISSN 
1499-2752
History 
  • Accepted for publication July 9, 2025
  • Published online October 1, 2025.

Article Versions

  • Latest version (August 1, 2025 - 04:00).
  • Latest version (September 1, 2025 - 04:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2025 by the Journal of Rheumatology

Author Information

  1. Aleksander Lenert1⇑,
  2. Jenna Thomason2,
  3. Melanie H. Smith3,
  4. Helena Abodeely1,
  5. Sandy D. Hong4,
  6. Courtney E. Kremer4,
  7. Petar S. Lenert1,
  8. T. Shawn Sato5,
  9. Sandra Hansmann6,
  10. Melissa Oliver7,
  11. Yongdong (Dan) Zhao8,
  12. Jonathan Templin9,
  13. Mary Vaughan-Sarrazin10,
  14. Robyn Domsic11,
  15. Daniel H. Solomon12 and
  16. Polly J. Ferguson13
  1. 1A. Lenert, MD, MS, H. Abodeely, P.S. Lenert, MD, PhD, Division of Immunology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA;
  2. 2J. Thomason, MD, MPH, Division of Rheumatology, University of Washington, Rheumatology Clinic at Harborview, Seattle, Washington, USA;
  3. 3M.H. Smith, MD, PhD, Weill Cornell Medicine, Hospital for Special Surgery, New York, New York, USA;
  4. 4S.D. Hong, MD, C.E. Kremer, ARNP, Division of Pediatric Rheumatology, University of Iowa Stead Family Children’s Hospital, Iowa City, Iowa, USA;
  5. 5T.S. Sato, MD, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA;
  6. 6S. Hansmann, MD, Department of Pediatrics, Division of Pediatric Rheumatology and autoinflammation reference center Tübingen (arcT), University Hospital Tübingen, Tübingen, Germany;
  7. 7M. Oliver, MD, Division of Pediatric Rheumatology, Indiana University School of Medicine, Indianapolis, Indiana, USA;
  8. 8Y. Zhao, MD, PhD, Division of Pediatric Rheumatology, Department of Pediatrics, University of Washington School of Medicine, Seattle Children’s Hospital, Seattle, Washington, USA;
  9. 9J. Templin, PhD, Department of Psychological and Quantitative Foundations, College of Education, University of Iowa, Iowa City, Iowa, USA;
  10. 10M. Vaughan-Sarrazin, PhD, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA;
  11. 11R. Domsic, MD, MPH, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;
  12. 12D.H. Solomon, MD, MPH, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA;
  13. 13P.J. Ferguson, MD, Division of Pediatric Rheumatology, Carver College of Medicine, University of Iowa Stead Family Children’s Hospital, Iowa City, Iowa, USA.
  1. Address correspondence to Dr. A. Lenert, Division of Immunology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA. Email: aleksander-lenert{at}uiowa.edu.

Article usage

Article usage: July 2025 to October 2025

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Aug 2025389028
Sep 2025420215
Oct 20259574430

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The Journal of Rheumatology: 52 (10)
The Journal of Rheumatology
Vol. 52, Issue 10
1 Oct 2025
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Quality of Life in Adult Patients With SAPHO Syndrome and Chronic Nonbacterial Osteomyelitis, and Comparison to Chronic Rheumatic and Inflammatory Diseases
Aleksander Lenert, Jenna Thomason, Melanie H. Smith, Helena Abodeely, Sandy D. Hong, Courtney E. Kremer, Petar S. Lenert, T. Shawn Sato, Sandra Hansmann, Melissa Oliver, Yongdong (Dan) Zhao, Jonathan Templin, Mary Vaughan-Sarrazin, Robyn Domsic, Daniel H. Solomon, Polly J. Ferguson
The Journal of Rheumatology Oct 2025, 52 (10) 1034-1042; DOI: 10.3899/jrheum.2025-0414

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Quality of Life in Adult Patients With SAPHO Syndrome and Chronic Nonbacterial Osteomyelitis, and Comparison to Chronic Rheumatic and Inflammatory Diseases
Aleksander Lenert, Jenna Thomason, Melanie H. Smith, Helena Abodeely, Sandy D. Hong, Courtney E. Kremer, Petar S. Lenert, T. Shawn Sato, Sandra Hansmann, Melissa Oliver, Yongdong (Dan) Zhao, Jonathan Templin, Mary Vaughan-Sarrazin, Robyn Domsic, Daniel H. Solomon, Polly J. Ferguson
The Journal of Rheumatology Oct 2025, 52 (10) 1034-1042; DOI: 10.3899/jrheum.2025-0414
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Keywords

CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS
COHORT STUDY
HEALTH-RELATED QUALITY OF LIFE
SAPHO SYNDROME
scoping review

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Keywords

  • chronic recurrent multifocal osteomyelitis
  • cohort study
  • HEALTH-RELATED QUALITY OF LIFE
  • SAPHO syndrome
  • scoping review

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