Abstract
Allopurinol is the most widely used urate-lowering medication worldwide. However, allopurinol failure is frequently observed in clinical practice. In this review, we provide a framework for assessing allopurinol failure, which includes failure of allopurinol to control serum urate concentrations, failure of allopurinol to control clinical symptoms, and failure of allopurinol due to an adverse drug reaction. Understanding the causes of allopurinol failure underpins the approach required to turn failure into success in gout management.
- Accepted for publication March 3, 2024.
- Copyright © 2024 by the Journal of Rheumatology
This is an Open Access article, which permits use, distribution, and reproduction, without modification, provided the original article is correctly cited and is not used for commercial purposes.
In this issue
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- Article
- Abstract
- Currently available ULTs and rank order for use
- What do allopurinol success and failure look like?
- Failure of allopurinol to achieve target SU
- Failure to achieve the desired clinical outcomes despite reducing the SU to target
- Adverse reaction requiring cessation of allopurinol
- What is the approach to allopurinol failure?
- Conclusion
- Footnotes
- REFERENCES
- Figures & Data
- Info & Metrics
- References