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Research ArticlePsoriatic Arthritis
Open Access

Safety of Guselkumab With and Without Prior Tumor Necrosis Factor Inhibitor Treatment: Pooled Results Across 4 Studies in Patients With Psoriatic Arthritis

Proton Rahman, Wolf-Henning Boehncke, Philip J. Mease, Alice B. Gottlieb, Iain B. McInnes, May Shawi, Yanli Wang, Shihong Sheng, Alexa P. Kollmeier, Elke Theander, Jenny Yu, Evan Leibowitz, A. Marilise Marrache and Laura C. Coates
The Journal of Rheumatology June 2023, 50 (6) 769-780; DOI: https://doi.org/10.3899/jrheum.220928
Proton Rahman
1P. Rahman, MD, Craig L. Dobbin Genetics Research Centre, Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, Canada;
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  • ORCID record for Proton Rahman
  • For correspondence: prahman@mun.ca
Wolf-Henning Boehncke
2W.H. Boehncke, MD, Geneva University Hospitals, Geneva, Switzerland;
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  • ORCID record for Wolf-Henning Boehncke
Philip J. Mease
3P.J. Mease, MD, Rheumatology Research, Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, Washington, USA;
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  • ORCID record for Philip J. Mease
Alice B. Gottlieb
4A.B. Gottlieb, MD, PhD, Icahn School of Medicine at Mount Sinai, New York, New York, USA;
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  • ORCID record for Alice B. Gottlieb
Iain B. McInnes
5I.B. McInnes, MD, PhD, University of Glasgow, Institute of Infection, Immunity and Inflammation, Glasgow, UK;
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  • ORCID record for Iain B. McInnes
May Shawi
6M. Shawi, PhD, Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, Pennsylvania, USA;
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  • ORCID record for May Shawi
Yanli Wang
7Y. Wang, MS, S. Sheng, PhD, J. Yu, MD, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA;
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Shihong Sheng
7Y. Wang, MS, S. Sheng, PhD, J. Yu, MD, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA;
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Alexa P. Kollmeier
8A.P. Kollmeier, MD, Immunology, Janssen Research & Development, LLC, San Diego, California, USA;
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Elke Theander
9E. Theander, MD, PhD, Janssen Scientific Affairs, LLC, Solna, Sweden;
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Jenny Yu
7Y. Wang, MS, S. Sheng, PhD, J. Yu, MD, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA;
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Evan Leibowitz
10E. Leibowitz, MD, Janssen Scientific Affairs, LLC, Horsham, Pennsylvania, USA;
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A. Marilise Marrache
11A.M. Marrache, PhD, Medical Affairs, Janssen Inc., Toronto, Ontario, Canada;
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Laura C. Coates
12L.C. Coates, MBChB, PhD, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
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Article Information

vol. 50 no. 6 769-780
DOI 
https://doi.org/10.3899/jrheum.220928
PubMed 
36642439

Published By 
The Journal of Rheumatology
Print ISSN 
0315-162X
Online ISSN 
1499-2752
History 
  • Accepted for publication December 28, 2022
  • Published online June 1, 2023.

Article Versions

  • Latest version (January 15, 2023 - 04:01).
  • Latest version (February 15, 2023 - 04:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2023 by the Journal of Rheumatology This is an Open Access article, which permits use, distribution, and reproduction, without modification, provided the original article is correctly cited and is not used for commercial purposes.

Author Information

  1. Proton Rahman1⇑,
  2. Wolf-Henning Boehncke2,
  3. Philip J. Mease3,
  4. Alice B. Gottlieb4,
  5. Iain B. McInnes5,
  6. May Shawi6,
  7. Yanli Wang7,
  8. Shihong Sheng7,
  9. Alexa P. Kollmeier8,
  10. Elke Theander9,
  11. Jenny Yu7,
  12. Evan Leibowitz10,
  13. A. Marilise Marrache11 and
  14. Laura C. Coates12
  1. 1P. Rahman, MD, Craig L. Dobbin Genetics Research Centre, Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, Canada;
  2. 2W.H. Boehncke, MD, Geneva University Hospitals, Geneva, Switzerland;
  3. 3P.J. Mease, MD, Rheumatology Research, Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, Washington, USA;
  4. 4A.B. Gottlieb, MD, PhD, Icahn School of Medicine at Mount Sinai, New York, New York, USA;
  5. 5I.B. McInnes, MD, PhD, University of Glasgow, Institute of Infection, Immunity and Inflammation, Glasgow, UK;
  6. 6M. Shawi, PhD, Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, Pennsylvania, USA;
  7. 7Y. Wang, MS, S. Sheng, PhD, J. Yu, MD, Janssen Research & Development, LLC, Spring House, Pennsylvania, USA;
  8. 8A.P. Kollmeier, MD, Immunology, Janssen Research & Development, LLC, San Diego, California, USA;
  9. 9E. Theander, MD, PhD, Janssen Scientific Affairs, LLC, Solna, Sweden;
  10. 10E. Leibowitz, MD, Janssen Scientific Affairs, LLC, Horsham, Pennsylvania, USA;
  11. 11A.M. Marrache, PhD, Medical Affairs, Janssen Inc., Toronto, Ontario, Canada;
  12. 12L.C. Coates, MBChB, PhD, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
  1. Address correspondence to Dr. P. Rahman, 154 LeMarchant Road, St. Clare’s Mercy Hospital, St. John’s, NL A1C 5B8, Canada. Email: prahman{at}mun.ca.

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The Journal of Rheumatology
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1 Jun 2023
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Safety of Guselkumab With and Without Prior Tumor Necrosis Factor Inhibitor Treatment: Pooled Results Across 4 Studies in Patients With Psoriatic Arthritis
Proton Rahman, Wolf-Henning Boehncke, Philip J. Mease, Alice B. Gottlieb, Iain B. McInnes, May Shawi, Yanli Wang, Shihong Sheng, Alexa P. Kollmeier, Elke Theander, Jenny Yu, Evan Leibowitz, A. Marilise Marrache, Laura C. Coates
The Journal of Rheumatology Jun 2023, 50 (6) 769-780; DOI: 10.3899/jrheum.220928

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Safety of Guselkumab With and Without Prior Tumor Necrosis Factor Inhibitor Treatment: Pooled Results Across 4 Studies in Patients With Psoriatic Arthritis
Proton Rahman, Wolf-Henning Boehncke, Philip J. Mease, Alice B. Gottlieb, Iain B. McInnes, May Shawi, Yanli Wang, Shihong Sheng, Alexa P. Kollmeier, Elke Theander, Jenny Yu, Evan Leibowitz, A. Marilise Marrache, Laura C. Coates
The Journal of Rheumatology Jun 2023, 50 (6) 769-780; DOI: 10.3899/jrheum.220928
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Keywords

ADVERSE EFFECTS
BIOLOGIC THERAPY
guselkumab
hepatic transaminase
PSORIATIC ARTHRITIS
SAFETY

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