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Research ArticleSystemic Lupus Erythematosus

Variations of C3 and C4 Before and During Pregnancy in Systemic Lupus Erythematosus: Association With Disease Flares and Obstetric Outcomes

Francesca Crisafulli, Laura Andreoli, Dina Zucchi, Rossella Reggia, Maria C. Gerardi, Daniele Lini, Chiara Tani, Sonia Zatti, Franco Franceschini, Marta Mosca and Angela Tincani
The Journal of Rheumatology October 2023, 50 (10) 1296-1301; DOI: https://doi.org/10.3899/jrheum.2022-1135
Francesca Crisafulli
1F. Crisafulli, MD, L. Andreoli, MD, D. Lini, MD, F. Franceschini, MD, A. Tincani, MD, Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, and Department of Clinical and Experimental Sciences, University of Brescia, Brescia;
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  • ORCID record for Francesca Crisafulli
  • For correspondence: crisafulli.francesca10{at}gmail.com
Laura Andreoli
1F. Crisafulli, MD, L. Andreoli, MD, D. Lini, MD, F. Franceschini, MD, A. Tincani, MD, Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, and Department of Clinical and Experimental Sciences, University of Brescia, Brescia;
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  • ORCID record for Laura Andreoli
Dina Zucchi
2D. Zucchi, MD, C. Tani, MD, M. Mosca, MD, Rheumatology Unit, Azienda Ospedaliero Universitaria Pisana, and Department of Clinical and Experimental Medicine, University of Pisa, Pisa;
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Rossella Reggia
3R. Reggia, MD, Internal Medicine, Casa di Cura San Camillo, Cremona;
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Maria C. Gerardi
4M.C. Gerardi, MD, Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, and Rheumatology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milano;
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Daniele Lini
1F. Crisafulli, MD, L. Andreoli, MD, D. Lini, MD, F. Franceschini, MD, A. Tincani, MD, Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, and Department of Clinical and Experimental Sciences, University of Brescia, Brescia;
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Chiara Tani
2D. Zucchi, MD, C. Tani, MD, M. Mosca, MD, Rheumatology Unit, Azienda Ospedaliero Universitaria Pisana, and Department of Clinical and Experimental Medicine, University of Pisa, Pisa;
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Sonia Zatti
5S. Zatti, MD, Obstetrics and Gynecology Unit, Spedali Civili and University of Brescia, Italy.
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Franco Franceschini
1F. Crisafulli, MD, L. Andreoli, MD, D. Lini, MD, F. Franceschini, MD, A. Tincani, MD, Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, and Department of Clinical and Experimental Sciences, University of Brescia, Brescia;
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Marta Mosca
2D. Zucchi, MD, C. Tani, MD, M. Mosca, MD, Rheumatology Unit, Azienda Ospedaliero Universitaria Pisana, and Department of Clinical and Experimental Medicine, University of Pisa, Pisa;
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Angela Tincani
1F. Crisafulli, MD, L. Andreoli, MD, D. Lini, MD, F. Franceschini, MD, A. Tincani, MD, Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, and Department of Clinical and Experimental Sciences, University of Brescia, Brescia;
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REFERENCES

  1. 1.↵
    1. Bundhun PK,
    2. Soogund MZ,
    3. Huang F
    . Impact of systemic lupus erythematosus on maternal and fetal outcomes following pregnancy: a meta-analysis of studies published between years 2001-2016. J Autoimmun 2017;79:17-27.
    OpenUrlCrossRefPubMed
  2. 2.
    1. Georgiou PE,
    2. Politi EN,
    3. Katsimbri P,
    4. Sakka V,
    5. Drosos AA
    . Outcome of lupus pregnancy: a controlled study. Rheumatology 2000;39:1014-9.
    OpenUrlCrossRefPubMed
  3. 3.
    1. Clowse ME,
    2. Jamison M,
    3. Myers E,
    4. James AH
    . A national study of the complications of lupus in pregnancy. Am J Obstet Gynecol 2008;199:127.e1-6.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Al Arfaj AS,
    2. Khalil N
    . Pregnancy outcome in 396 pregnancies in patients with SLE in Saudi Arabia. Lupus 2010;19:1665-73.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Cortés-Hernández J,
    2. Ordi-Ros J,
    3. Paredes F,
    4. Casellas M,
    5. Castillo F,
    6. Vilardell-Tarres M
    . Clinical predictors of fetal and maternal outcome in systemic lupus erythematosus: a prospective study of 103 pregnancies. Rheumatology 2002;41:643-50.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Chighizola CB,
    2. Lonati PA,
    3. Trespidi L,
    4. Meroni PL,
    5. Tedesco F
    . The complement system in the pathophysiology of pregnancy and in systemic autoimmune rheumatic diseases during pregnancy. Front Immunol 2020;11:2084.
    OpenUrl
  7. 7.↵
    1. Reggia R,
    2. Ziglioli T,
    3. Andreoli L, et al.
    Primary anti-phospholipid syndrome: any role for serum complement levels in predicting pregnancy complications? Rheumatology 2012;51:2186-90.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Lynch AM,
    2. Salmon JE
    . Dysregulated complement activation as a common pathway of injury in preeclampsia and other pregnancy complications. Placenta 2010;31:561-7.
    OpenUrlCrossRefPubMed
  9. 9.
    1. Teirilä L,
    2. Heikkinen-Eloranta J,
    3. Kotimaa J,
    4. Meri S,
    5. Lokki AI
    . Regulation of the complement system and immunological tolerance in pregnancy. Semin Immunol 2019;45:101337.
    OpenUrl
  10. 10.↵
    1. Kim MY,
    2. Guerra MM,
    3. Kaplowitz E, et al.
    Complement activation predicts adverse pregnancy outcome in patients with systemic lupus erythematosus and/or antiphospholipid antibodies. Ann Rheum Dis 2018;77:549-55.
    OpenUrlAbstract/FREE Full Text
  11. 11.↵
    1. Ho A,
    2. Barr SG,
    3. Magder LS,
    4. Petri M
    . A decrease in complement is associated with increased renal and hematologic activity in patients with systemic lupus erythematosus. Arthritis Rheum 2001; 44:2350-7.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Buyon JP,
    2. Kim MY,
    3. Guerra MM, et al.
    Kidney outcomes and risk factors for nephritis (flare/de novo) in a multiethnic cohort of pregnant patients with lupus. Clin J Am Soc Nephrol 2017; 12:940-6.
    OpenUrlAbstract/FREE Full Text
  13. 13.↵
    1. Wu J,
    2. Zhang WH,
    3. Ma J,
    4. Bao C,
    5. Liu J,
    6. Di W
    . Prediction of fetal loss in Chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study. BMJ Open 2019;9:e023849.
    OpenUrlAbstract/FREE Full Text
  14. 14.↵
    1. Buyon JP,
    2. Kim MY,
    3. Guerra MM, et al.
    Predictors of pregnancy outcomes in patients with lupus: a cohort study. Ann Intern Med 2015;163:153-63.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Hochberg MC
    . Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725.
    OpenUrlCrossRefPubMed
  16. 16.↵
    1. Petri M,
    2. Orbai AM,
    3. Alarcón GS, et al.
    Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012;64:2677-86.
    OpenUrlCrossRefPubMed
  17. 17.↵
    1. Buyon JP,
    2. Kalunian KC,
    3. Ramsey-Goldman R, et al.
    Assessing disease activity in SLE patients during pregnancy. Lupus 1999;8:677-84.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Andreoli L,
    2. Bertsias GK,
    3. Agmon-Levin N, et al.
    EULAR recommendations for women’s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. Ann Rheum Dis 2017;76:476-85.
    OpenUrlAbstract/FREE Full Text
  19. 19.↵
    1. Sammaritano LR,
    2. Bermas BL,
    3. Chakravarty EE, et al.
    2020 American College of Rheumatology Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases. Arthritis Rheumatol 2020;72:529-56.
    OpenUrl
  20. 20.↵
    1. Chen JY,
    2. Wu YL,
    3. Mok MY, et al.
    Effects of complement C4 gene copy number variations, size dichotomy, and C4A deficiency on genetic risk and clinical presentation of systemic lupus erythematosus in East Asian populations. Arthritis Rheumatol 2016;68:1442-53.
    OpenUrl
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1 Oct 2023
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Variations of C3 and C4 Before and During Pregnancy in Systemic Lupus Erythematosus: Association With Disease Flares and Obstetric Outcomes
Francesca Crisafulli, Laura Andreoli, Dina Zucchi, Rossella Reggia, Maria C. Gerardi, Daniele Lini, Chiara Tani, Sonia Zatti, Franco Franceschini, Marta Mosca, Angela Tincani
The Journal of Rheumatology Oct 2023, 50 (10) 1296-1301; DOI: 10.3899/jrheum.2022-1135

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Variations of C3 and C4 Before and During Pregnancy in Systemic Lupus Erythematosus: Association With Disease Flares and Obstetric Outcomes
Francesca Crisafulli, Laura Andreoli, Dina Zucchi, Rossella Reggia, Maria C. Gerardi, Daniele Lini, Chiara Tani, Sonia Zatti, Franco Franceschini, Marta Mosca, Angela Tincani
The Journal of Rheumatology Oct 2023, 50 (10) 1296-1301; DOI: 10.3899/jrheum.2022-1135
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Keywords

complement C3
complement C4
PREGNANCY
SYSTEMIC LUPUS ERYTHEMATOSUS

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